arecoline has been researched along with Diabetes Mellitus, Type 2 in 5 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the effects of arecoline on hepatic insulin resistance in type 2 diabetes rats and to elucidate its possible mechanism." | 7.80 | [The role of arecoline on hepatic insulin resistance in type 2 diabetes rats]. ( He, JQ; Hu, B; Ling, HY; Qi, ZQ; Yang, SS; Yao, QX; Zhang, KF, 2014) |
| "Our preliminary studies have identified a large number of genes relevant to obesity, T2D and metabolic syndrome whose expression was changed significantly in human TPH1 cells following incubation with betel-nut derived arecoline or with MNPA." | 4.02 | Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study. ( Boucher, BJ; Cardosa, SR; Hitman, GA; Lowe, R; Mein, CA; Ogunkolade, BW; Savage, E, 2021) |
| "To explore the effects of arecoline on hepatic insulin resistance in type 2 diabetes rats and to elucidate its possible mechanism." | 3.80 | [The role of arecoline on hepatic insulin resistance in type 2 diabetes rats]. ( He, JQ; Hu, B; Ling, HY; Qi, ZQ; Yang, SS; Yao, QX; Zhang, KF, 2014) |
| "Metformin has a protective effect on arecoline-induced mouse oocytes apoptosis." | 1.56 | Metformin protects against mouse oocyte apoptosis defects induced by arecoline. ( Li, WD; Shen, W; Sun, QY; Yin, S; Zang, CJ; Zhao, M, 2020) |
| "Arecoline is an alkaloid-type natural product found in betel nuts." | 1.37 | Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes. ( Chang, WC; Chou, PC; Hsiao, PJ; Hsieh, PC; Hsieh, TJ; Lin, KD; Shin, SJ; Wu, MT, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WD | 1 |
| Zang, CJ | 1 |
| Yin, S | 1 |
| Shen, W | 1 |
| Sun, QY | 1 |
| Zhao, M | 1 |
| Cardosa, SR | 1 |
| Ogunkolade, BW | 1 |
| Lowe, R | 1 |
| Savage, E | 1 |
| Mein, CA | 1 |
| Boucher, BJ | 1 |
| Hitman, GA | 1 |
| Ling, HY | 1 |
| Yao, QX | 1 |
| Qi, ZQ | 1 |
| Yang, SS | 1 |
| He, JQ | 1 |
| Zhang, KF | 1 |
| Hu, B | 1 |
| Lee, LM | 1 |
| Chang, CK | 1 |
| Cheng, KC | 1 |
| Kou, DH | 1 |
| Liu, IM | 1 |
| Cheng, JT | 1 |
| Hsieh, TJ | 1 |
| Hsieh, PC | 1 |
| Wu, MT | 1 |
| Chang, WC | 1 |
| Hsiao, PJ | 1 |
| Lin, KD | 1 |
| Chou, PC | 1 |
| Shin, SJ | 1 |
5 other studies available for arecoline and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Metformin protects against mouse oocyte apoptosis defects induced by arecoline.
Topics: Animals; Apoptosis; Arecoline; Diabetes Mellitus, Type 2; Female; Meiosis; Metformin; Mice; Mice, In | 2020 |
Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study.
Topics: Areca; Arecoline; Biomarkers; Diabetes Mellitus, Type 2; Follow-Up Studies; Gene Expression Regulati | 2021 |
[The role of arecoline on hepatic insulin resistance in type 2 diabetes rats].
Topics: Animals; Arecoline; Constitutive Androstane Receptor; Diabetes Mellitus, Experimental; Diabetes Mell | 2014 |
Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats.
Topics: Animals; Arecoline; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Mo | 2008 |
Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Areca; Arecoline; Carrier Proteins; Diabetes Mellitus, Type 2; Fa | 2011 |