arecoline has been researched along with Depressive Disorder in 14 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared central cholinergic responsiveness (using the latency to induction of rapid eye movement sleep after arecoline challenge as a response marker) in 90 subjects: patients with major depressive disorder (MDD) (n = 53), nonaffective psychiatric controls (n = 17), and normal controls (n = 20)." | 3.67 | Cholinergic REM sleep induction response correlation with endogenous major depressive subtype. ( Bell, J; Dube, S; Jackson, E; Jones, D; Kelwala, S; Sitaram, N, 1985) |
| "Two lines of rats that were selectively bred to vary in their sensitivity to the anticholinesterase DFP exhibited different degrees of behavioral depression after injection of the muscarinic agonist arecoline (2 mg/kg)." | 3.67 | Selective breeding for increased cholinergic function: development of a new animal model of depression. ( Overstreet, DH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spiegel, R | 1 |
| Nurnberger, J | 1 |
| Sitaram, N | 9 |
| Gershon, ES | 2 |
| Gillin, JC | 4 |
| Mendelson, WB | 1 |
| Nurnberger, JI | 1 |
| Dahl, RE | 1 |
| Ryan, ND | 1 |
| Perel, J | 1 |
| Birmaher, B | 1 |
| al-Shabbout, M | 1 |
| Nelson, B | 1 |
| Puig-Antich, J | 1 |
| Sutton, L | 1 |
| Ruiz, C | 1 |
| Kelsoe, J | 1 |
| Dupont, RM | 1 |
| Darko, D | 1 |
| Risch, SC | 1 |
| Golshan, S | 1 |
| Janowsky, D | 1 |
| Wager, S | 1 |
| Robinson, D | 1 |
| Goetz, R | 1 |
| Nunes, E | 1 |
| Gully, R | 1 |
| Quitkin, F | 1 |
| Grabowski, J | 2 |
| Brown, A | 1 |
| Bruza, D | 1 |
| Dube, S | 4 |
| Keshavan, M | 2 |
| Davies, A | 1 |
| Reynal, P | 1 |
| Jones, DA | 1 |
| Bell, J | 2 |
| Jones, D | 2 |
| Kelwala, S | 1 |
| Jackson, E | 1 |
| Overstreet, DH | 1 |
| Kumar, N | 1 |
| Ettedgui, E | 1 |
| Pohl, R | 1 |
| Abramson, LB | 1 |
| Brown, AJ | 1 |
1 review available for arecoline and Depressive Disorder
| Article | Year |
|---|---|
Acetylcholine, sleep, and depression.
Topics: Acetylcholine; Animals; Arecoline; Arousal; Depressive Disorder; Humans; Models, Biological; Physost | 1982 |
3 trials available for arecoline and Depressive Disorder
| Article | Year |
|---|---|
[Prediction of treatment outcome with antidepressants: are short REM latencies diagnostically and prognostically reliable indicators?].
Topics: Adult; Age Factors; Amitriptyline; Antidepressive Agents; Arecoline; Clinical Trials as Topic; Depre | 1984 |
The cholinergic rapid eye movement induction test with arecoline in depression.
Topics: Arecoline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Infusi | 1991 |
Cholinergic REM sleep induction in atypical depression.
Topics: Adolescent; Adult; Arecoline; Depressive Disorder; Female; Humans; Male; Middle Aged; Randomized Con | 1990 |
10 other studies available for arecoline and Depressive Disorder
| Article | Year |
|---|---|
A twin study of cholinergic REM induction.
Topics: Adolescent; Adult; Arecoline; Depressive Disorder; Diseases in Twins; Female; Humans; Male; Receptor | 1983 |
Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder.
Topics: Acetylcholine; Adult; Arecoline; Bipolar Disorder; Depressive Disorder; Electroencephalography; Evok | 1982 |
Cholinergic REM induction test with arecoline in depressed children.
Topics: Aging; Arecoline; Blood Pressure; Child; Depressive Disorder; Electroencephalography; Female; Growth | 1994 |
Heart rate change following sleep infusion of arecoline.
Topics: Arecoline; Depressive Disorder; Female; Heart Rate; Humans; Middle Aged; Sleep, REM | 1987 |
The association of supersensitive cholinergic REM-induction and affective illness within pedigrees.
Topics: Acetylcholine; Adult; Arecoline; Brain; Depressive Disorder; Electroencephalography; Female; Humans; | 1987 |
Cardioacceleratory responses to arecoline infusion during sleep in depressive, anxious, and normal subjects.
Topics: Adult; Arecoline; Depressive Disorder; Fear; Female; Heart Rate; Humans; Infusions, Intravenous; Mal | 1987 |
Cholinergic REM sleep induction response correlation with endogenous major depressive subtype.
Topics: Adult; Aged; Arecoline; Bipolar Disorder; Brain; Depressive Disorder; Electroencephalography; Female | 1985 |
Selective breeding for increased cholinergic function: development of a new animal model of depression.
Topics: Animals; Arecoline; Breeding; Depression; Depressive Disorder; Disease Models, Animal; Electroshock; | 1986 |
Cholinergic REM induction response: separation of anxiety and depression.
Topics: Adult; Aged; Anxiety Disorders; Arecoline; Depressive Disorder; Electroencephalography; Female; Huma | 1985 |
A cardioacceleratory response to low-dose arecoline infusion during sleep in patients with major depressive disorder: relationship to REM sleep induction.
Topics: Adult; Aged; Arecoline; Depressive Disorder; Female; Heart Rate; Humans; Male; Middle Aged; Sleep, R | 1985 |