Page last updated: 2024-10-22

arecoline and Dementia

arecoline has been researched along with Dementia in 2 studies

Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia."9.05Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia. ( Christie, JE; Ferguson, J; Glen, AI; Shering, A, 1981)
"25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia."5.05Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia. ( Christie, JE; Ferguson, J; Glen, AI; Shering, A, 1981)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davies, P1
Christie, JE1
Shering, A1
Ferguson, J1
Glen, AI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
M2 Receptor Measurements in Aging and in Alzheimer's Disease[NCT00001917]150 participants Observational1999-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for arecoline and Dementia

ArticleYear
An update on the neurochemistry of Alzheimer disease.
    Advances in neurology, 1983, Volume: 38

    Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cho

1983

Trials

1 trial available for arecoline and Dementia

ArticleYear
Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.
    The British journal of psychiatry : the journal of mental science, 1981, Volume: 138

    Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Dementia; Dose-Response Relationship, Drug;

1981