arecoline has been researched along with Chemical Dependence in 16 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arecoline is a nicotinic acetylcholine receptor agonist expressed in Xenopus oocytes." | 2.66 | Betel quid dependence mechanism and potential cessation therapy. ( Ko, AM; Ko, YC; Lee, CH, 2020) |
| "Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm ( Areca catechu) endemic to South and Southeast Asia." | 2.61 | DARK Classics in Chemical Neuroscience: Arecoline. ( Alpyshov, ET; Amstislavskaya, TG; Bashirzade, A; Demin, KA; Ho, YJ; Kalueff, AV; Lakstygal, AM; Serikuly, N; Shevyrin, VA; Tang, Z; Volgin, AD; Wang, D; Wang, J; Wang, M; Wappler-Guzzetta, EA; Yakovlev, OA; Yan, D, 2019) |
| "We present a systematic review of substance use disorder (SUD) to Areca catechu nut (AN) and AN containing betel quid (ANcBQ) with emphasis on dependence resulting from chewing of tobacco-free ANcBQ." | 2.55 | Intoxication and substance use disorder to Areca catechu nut containing betel quid: A review of epidemiological evidence, pharmacological basis and social factors influencing quitting strategies. ( Ko, YC; Lee, CH; Osborne, PG; Wu, MT, 2017) |
| "Arecoline was detected before chewing in 22 subjects, exceeding the 0." | 1.36 | Salivary arecoline levels during areca nut chewing in human volunteers. ( Cox, S; Ghu, S; Vickers, ER; Zoellner, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Pi, M | 1 |
| Yue, K | 1 |
| Ma, B | 1 |
| Tian, X | 1 |
| Liu, W | 1 |
| Sun, B | 1 |
| Shu, X | 1 |
| Ko, AM | 3 |
| Lee, CH | 3 |
| Ko, YC | 3 |
| Winger, G | 1 |
| Osborne, PG | 1 |
| Wu, MT | 1 |
| Tsai, MH | 1 |
| Li, TC | 1 |
| Li, CI | 1 |
| Gritz, ER | 1 |
| Lam, C | 1 |
| Chiu, CF | 1 |
| Liu, CS | 1 |
| Lai, CC | 1 |
| Hsu, WY | 1 |
| Tamí-Maury, I | 1 |
| Lu, IY | 1 |
| Lin, CC | 1 |
| Volgin, AD | 1 |
| Bashirzade, A | 1 |
| Amstislavskaya, TG | 1 |
| Yakovlev, OA | 1 |
| Demin, KA | 1 |
| Ho, YJ | 1 |
| Wang, D | 1 |
| Shevyrin, VA | 1 |
| Yan, D | 1 |
| Tang, Z | 1 |
| Wang, J | 1 |
| Wang, M | 1 |
| Alpyshov, ET | 1 |
| Serikuly, N | 1 |
| Wappler-Guzzetta, EA | 1 |
| Lakstygal, AM | 1 |
| Kalueff, AV | 1 |
| Cox, S | 1 |
| Vickers, ER | 1 |
| Ghu, S | 1 |
| Zoellner, H | 1 |
| Bhat, SJ | 1 |
| Blank, MD | 1 |
| Balster, RL | 1 |
| Nichter, M | 2 |
| Chen, PH | 1 |
| Tu, HP | 1 |
| Wang, SJ | 1 |
| Lee, CP | 1 |
| Chiang, TA | 1 |
| Tsai, YS | 1 |
| Shieh, TY | 1 |
| Ko, CH | 1 |
| Chiang, SL | 1 |
| Yoganathan, P | 1 |
| Pichini, S | 1 |
| Puig, C | 1 |
| Zuccaro, P | 1 |
| Marchei, E | 1 |
| Pellegrini, M | 1 |
| Murillo, J | 1 |
| Vall, O | 1 |
| Pacifici, R | 1 |
| García-Algar, O | 1 |
| Molin, S | 1 |
| Plewig, G | 1 |
| Murti, PR | 1 |
| Bhonsle, RB | 1 |
| Gupta, PC | 1 |
| Daftary, DK | 1 |
| Pindborg, JJ | 1 |
| Mehta, FS | 1 |
| Marshall, M | 1 |
| Sullivan, RJ | 1 |
| Allen, JS | 1 |
| Otto, C | 1 |
| Tiobech, J | 1 |
| Nero, K | 1 |
| Chu, NS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NIH-NCI U54 University of Guam/Cancer Center of Hawaii Partnership Full Project II: The Betel Nut Intervention Trial[NCT02942745] | 276 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| Cross-Cultural Adaptation of a Betel Quid Cessation Program and Evaluation of Its Effectiveness in a Malaysian High-Risk Community[NCT05782166] | 92 participants (Anticipated) | Interventional | 2024-01-02 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for arecoline and Chemical Dependence
| Article | Year |
|---|---|
Betel quid dependence mechanism and potential cessation therapy.
Topics: Animals; Areca; Arecoline; Behavior, Addictive; Brain Chemistry; Humans; Magnetic Resonance Imaging; | 2020 |
Intoxication and substance use disorder to Areca catechu nut containing betel quid: A review of epidemiological evidence, pharmacological basis and social factors influencing quitting strategies.
Topics: Animals; Areca; Arecoline; Calcium Compounds; Humans; Mastication; Nicotiana; Nuts; Oxides; Substanc | 2017 |
DARK Classics in Chemical Neuroscience: Arecoline.
Topics: Animals; Arecoline; Humans; Substance-Related Disorders | 2019 |
Betel chewing creeps into the New World.
Topics: Areca; Arecoline; Asia; Carcinoma, Squamous Cell; Cariostatic Agents; Cultural Characteristics; Huma | 2002 |
Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing.
Topics: Animals; Areca; Arecoline; Collagen; Cross Reactions; Disease Susceptibility; Fibroblasts; Humans; I | 1995 |
Neurological aspects of areca and betel chewing.
Topics: Areca; Arecoline; Arousal; Autonomic Nervous System; Brain; Dose-Response Relationship, Drug; Euphor | 2002 |
10 other studies available for arecoline and Chemical Dependence
| Article | Year |
|---|---|
Susceptibility to arecoline in male C57BL/6 J mice correlates with age factor.
Topics: Adolescent; Adult; Age Factors; Alkaloids; Animals; Arecoline; Humans; Male; Mice; Mice, Inbred C57B | 2023 |
Nicotinic aspects of the discriminative stimulus effects of arecoline.
Topics: Animals; Arecoline; Behavior, Animal; Dihydro-beta-Erythroidine; Discrimination Learning; Mecamylami | 2021 |
Development and preliminary validation of a mandarin Chinese language questionnaire measuring betel quid dependency among adults in Taiwan.
Topics: Adult; Areca; Arecoline; Asian People; Cross-Sectional Studies; Factor Analysis, Statistical; Female | 2019 |
Salivary arecoline levels during areca nut chewing in human volunteers.
Topics: Adolescent; Adult; Areca; Arecoline; Australia; Binomial Distribution; Case-Control Studies; Chi-Squ | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Areca nut dependence among chewers in a South Indian community who do not also use tobacco.
Topics: Adolescent; Adult; Aged; Areca; Arecoline; Behavior, Addictive; Child; Female; Health Knowledge, Att | 2010 |
Monoamine oxidase A variants are associated with heavy betel quid use.
Topics: Adult; Aged; Alcohol Drinking; Animals; Areca; Arecoline; Cell Survival; Cells, Cultured; Female; Ge | 2012 |
Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project".
Topics: Abortion, Induced; Adult; Arecoline; Body Height; Cholinergic Agonists; Cocaine; Dopamine Uptake Inh | 2005 |
[Betel quid chewing: traditional habit with side effects].
Topics: Areca; Arecoline; Asia, Southeastern; Asthma; Birth Weight; Blood Pressure; Central Nervous System S | 2007 |
Betel chewing incompletely understood in journal supplement.
Topics: Areca; Arecoline; Humans; Plants, Medicinal; Substance-Related Disorders | 1994 |
Effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia.
Topics: Adult; Areca; Arecoline; Cholinergic Agonists; Cross-Sectional Studies; Diagnosis, Dual (Psychiatry) | 2000 |