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arecoline and Aging

arecoline has been researched along with Aging in 17 studies

Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)."4.76Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984)
" The present study examined whether amnesia induced by scopolamine could be counteracted in mice by arecoline, a cholinergic agonist, or by other drugs, epinephrine or glucose, which have been found to enhance memory in aged rodents and humans."3.67Attenuation of scopolamine-induced amnesia in mice. ( Croul, CE; Gold, PE; Stone, WS, 1988)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19908 (47.06)18.7374
1990's6 (35.29)18.2507
2000's3 (17.65)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lagou, M1
Gillespie, J1
Kirkwood, T1
Harvey, I1
Drake, MJ1
Goodnick, P1
Gershon, S1
Gibson, G1
Barclay, L1
Blass, J1
Ono, M1
Minamoto, Y1
Shibata, S1
Watanabe, S1
Cizza, G1
Calogero, AE1
Brady, LS1
Bagdy, G1
Bergamini, E1
Blackman, MR1
Chrousos, GP1
Gold, PW1
Dahl, RE1
Ryan, ND1
Perel, J1
Birmaher, B1
al-Shabbout, M1
Nelson, B1
Puig-Antich, J1
Culp, DJ1
Richardson, LA1
Avery, EE1
Baker, LD1
Asthana, S1
Lluel, P1
Palea, S1
Barras, M1
Grandadam, F1
Heudes, D1
Bruneval, P1
Corman, B1
Martin, DJ1
Uchida, S1
Suzuki, A1
Kagitani, F1
Hotta, H1
Barnes, JM1
Costall, B1
Coughlan, J1
Domeney, AM1
Gerrard, PA1
Kelly, ME1
Naylor, RJ1
Onaivi, ES1
Tomkins, DM1
Tyers, MB1
Soncrant, TT1
Holloway, HW1
Greig, NH1
Rapoport, SI1
Rooney, TA1
Nahorski, SR1
Tariot, PN1
Cohen, RM1
Welkowitz, JA1
Sunderland, T1
Newhouse, PA1
Murphy, DL1
Weingartner, H1
Stone, WS1
Croul, CE1
Gold, PE1
Dunnett, SB1
Evenden, JL1
Iversen, SD1
McFarlane, JE1
Fong, KT1

Reviews

3 reviews available for arecoline and Aging

ArticleYear
Chemotherapy of cognitive disorders in geriatric subjects.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5

    Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co

1984
The role of the cholinergic system in thiamin deficiency.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Animals; Arecoline; Atropine; Behavior, Animal; Brain; Diet

1982
Potential role of muscarinic agonists in Alzheimer's disease.
    Drugs & aging, 1997, Volume: 11, Issue:6

    Topics: Aging; Alzheimer Disease; Arecoline; Clinical Trials as Topic; Cognition; Drug Evaluation; Drugs, In

1997

Trials

1 trial available for arecoline and Aging

ArticleYear
Multiple-dose arecoline infusions in Alzheimer's disease.
    Archives of general psychiatry, 1988, Volume: 45, Issue:10

    Topics: Aged; Aging; Alzheimer Disease; Arecoline; Clinical Trials as Topic; Cognition; Dose-Response Relati

1988

Other Studies

13 other studies available for arecoline and Aging

ArticleYear
Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:3

    Topics: Age Factors; Aging; Animals; Arecoline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug;

2006
Attenuating effect of arecoline and physostigmine on an impairment of mealtime-associated activity rhythm in old rats.
    Physiology & behavior, 1995, Volume: 57, Issue:1

    Topics: Activity Cycles; Aging; Animals; Arecoline; Feeding Behavior; Male; Memory; Models, Biological; Moto

1995
Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age.
    Endocrinology, 1994, Volume: 134, Issue:4

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Arecoline; Brain; Corticotropin-Releasing Hormone; Hipp

1994
Cholinergic REM induction test with arecoline in depressed children.
    Psychiatry research, 1994, Volume: 51, Issue:3

    Topics: Aging; Arecoline; Blood Pressure; Child; Depressive Disorder; Electroencephalography; Female; Growth

1994
Regulation of mucous acinar exocrine secretion with age.
    Journal of dental research, 1996, Volume: 75, Issue:1

    Topics: Aging; Animals; Arecoline; Dose-Response Relationship, Drug; Exocrine Glands; Glycoproteins; Logisti

1996
Functional and morphological modifications of the urinary bladder in aging female rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Arecoli

2000
Effects of age on cholinergic vasodilation of cortical cerebral blood vessels in rats.
    Neuroscience letters, 2000, Nov-17, Volume: 294, Issue:2

    Topics: Acetylcholine; Aging; Animals; Arecoline; Basal Nucleus of Meynert; Blood Flow Velocity; Blood Press

2000
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:4

    Topics: Aging; Animals; Arecoline; Brain; Callithrix; Choline O-Acetyltransferase; Cognition; Female; Habitu

1990
Regional brain metabolic responsivity to the muscarinic cholinergic agonist arecoline is similar in young and aged Fischer-344 rats.
    Brain research, 1989, May-22, Volume: 487, Issue:2

    Topics: Aging; Animals; Arecoline; Brain; Cholinergic Fibers; Dose-Response Relationship, Drug; Glucose; Mal

1989
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N

1987
Attenuation of scopolamine-induced amnesia in mice.
    Psychopharmacology, 1988, Volume: 96, Issue:3

    Topics: Aging; Amnesia; Animals; Arecoline; Epinephrine; Glucose; Male; Mice; Mice, Inbred ICR; Scopolamine

1988
Delay-dependent short-term memory deficits in aged rats.
    Psychopharmacology, 1988, Volume: 96, Issue:2

    Topics: Aging; Animals; Arecoline; Body Weight; Conditioning, Operant; Male; Memory, Short-Term; Physostigmi

1988
Differences in the effect of drugs on young and old hearts of the house cricket, Acheta domesticus (L.).
    Comparative and general pharmacology, 1972, Volume: 3, Issue:11

    Topics: Acetylcholine; Age Factors; Aging; Animals; Arecoline; Atropine; Heart; Heart Rate; In Vitro Techniq

1972