arecoline and Aging
arecoline has been researched along with Aging in 17 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| " The present study examined whether amnesia induced by scopolamine could be counteracted in mice by arecoline, a cholinergic agonist, or by other drugs, epinephrine or glucose, which have been found to enhance memory in aged rodents and humans." | 3.67 | Attenuation of scopolamine-induced amnesia in mice. ( Croul, CE; Gold, PE; Stone, WS, 1988) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lagou, M | 1 |
| Gillespie, J | 1 |
| Kirkwood, T | 1 |
| Harvey, I | 1 |
| Drake, MJ | 1 |
| Goodnick, P | 1 |
| Gershon, S | 1 |
| Gibson, G | 1 |
| Barclay, L | 1 |
| Blass, J | 1 |
| Ono, M | 1 |
| Minamoto, Y | 1 |
| Shibata, S | 1 |
| Watanabe, S | 1 |
| Cizza, G | 1 |
| Calogero, AE | 1 |
| Brady, LS | 1 |
| Bagdy, G | 1 |
| Bergamini, E | 1 |
| Blackman, MR | 1 |
| Chrousos, GP | 1 |
| Gold, PW | 1 |
| Dahl, RE | 1 |
| Ryan, ND | 1 |
| Perel, J | 1 |
| Birmaher, B | 1 |
| al-Shabbout, M | 1 |
| Nelson, B | 1 |
| Puig-Antich, J | 1 |
| Culp, DJ | 1 |
| Richardson, LA | 1 |
| Avery, EE | 1 |
| Baker, LD | 1 |
| Asthana, S | 1 |
| Lluel, P | 1 |
| Palea, S | 1 |
| Barras, M | 1 |
| Grandadam, F | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Corman, B | 1 |
| Martin, DJ | 1 |
| Uchida, S | 1 |
| Suzuki, A | 1 |
| Kagitani, F | 1 |
| Hotta, H | 1 |
| Barnes, JM | 1 |
| Costall, B | 1 |
| Coughlan, J | 1 |
| Domeney, AM | 1 |
| Gerrard, PA | 1 |
| Kelly, ME | 1 |
| Naylor, RJ | 1 |
| Onaivi, ES | 1 |
| Tomkins, DM | 1 |
| Tyers, MB | 1 |
| Soncrant, TT | 1 |
| Holloway, HW | 1 |
| Greig, NH | 1 |
| Rapoport, SI | 1 |
| Rooney, TA | 1 |
| Nahorski, SR | 1 |
| Tariot, PN | 1 |
| Cohen, RM | 1 |
| Welkowitz, JA | 1 |
| Sunderland, T | 1 |
| Newhouse, PA | 1 |
| Murphy, DL | 1 |
| Weingartner, H | 1 |
| Stone, WS | 1 |
| Croul, CE | 1 |
| Gold, PE | 1 |
| Dunnett, SB | 1 |
| Evenden, JL | 1 |
| Iversen, SD | 1 |
| McFarlane, JE | 1 |
| Fong, KT | 1 |
Reviews
3 reviews available for arecoline and Aging
| Article | Year |
|---|---|
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
The role of the cholinergic system in thiamin deficiency.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Animals; Arecoline; Atropine; Behavior, Animal; Brain; Diet | 1982 |
Potential role of muscarinic agonists in Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Arecoline; Clinical Trials as Topic; Cognition; Drug Evaluation; Drugs, In | 1997 |
Trials
1 trial available for arecoline and Aging
| Article | Year |
|---|---|
Multiple-dose arecoline infusions in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Arecoline; Clinical Trials as Topic; Cognition; Dose-Response Relati | 1988 |
Other Studies
13 other studies available for arecoline and Aging
| Article | Year |
|---|---|
Muscarinic stimulation of the mouse isolated whole bladder: physiological responses in young and ageing mice.
Topics: Age Factors; Aging; Animals; Arecoline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; | 2006 |
Attenuating effect of arecoline and physostigmine on an impairment of mealtime-associated activity rhythm in old rats.
Topics: Activity Cycles; Aging; Animals; Arecoline; Feeding Behavior; Male; Memory; Models, Biological; Moto | 1995 |
Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Arecoline; Brain; Corticotropin-Releasing Hormone; Hipp | 1994 |
Cholinergic REM induction test with arecoline in depressed children.
Topics: Aging; Arecoline; Blood Pressure; Child; Depressive Disorder; Electroencephalography; Female; Growth | 1994 |
Regulation of mucous acinar exocrine secretion with age.
Topics: Aging; Animals; Arecoline; Dose-Response Relationship, Drug; Exocrine Glands; Glycoproteins; Logisti | 1996 |
Functional and morphological modifications of the urinary bladder in aging female rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Arecoli | 2000 |
Effects of age on cholinergic vasodilation of cortical cerebral blood vessels in rats.
Topics: Acetylcholine; Aging; Animals; Arecoline; Basal Nucleus of Meynert; Blood Flow Velocity; Blood Press | 2000 |
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates.
Topics: Aging; Animals; Arecoline; Brain; Callithrix; Choline O-Acetyltransferase; Cognition; Female; Habitu | 1990 |
Regional brain metabolic responsivity to the muscarinic cholinergic agonist arecoline is similar in young and aged Fischer-344 rats.
Topics: Aging; Animals; Arecoline; Brain; Cholinergic Fibers; Dose-Response Relationship, Drug; Glucose; Mal | 1989 |
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N | 1987 |
Attenuation of scopolamine-induced amnesia in mice.
Topics: Aging; Amnesia; Animals; Arecoline; Epinephrine; Glucose; Male; Mice; Mice, Inbred ICR; Scopolamine | 1988 |
Delay-dependent short-term memory deficits in aged rats.
Topics: Aging; Animals; Arecoline; Body Weight; Conditioning, Operant; Male; Memory, Short-Term; Physostigmi | 1988 |
Differences in the effect of drugs on young and old hearts of the house cricket, Acheta domesticus (L.).
Topics: Acetylcholine; Age Factors; Aging; Animals; Arecoline; Atropine; Heart; Heart Rate; In Vitro Techniq | 1972 |