Disease models & mechanisms, 2018, 11-16, Volume: 11, Issue:11
Kidney stone disease involves the aggregation of stone-forming salts consequent to solute supersaturation in urine. The development of novel therapeutic agents for this predominantly metabolic and biochemical disorder have been hampered by the lack of a practical pre-clinical model amenable to drug screening. Here, Topics: Animals; Arbutin; Birefringence; Calcium; Calcium Oxalate; Diphosphonates; Drosophila melanogaster; Drug Evaluation, Preclinical; Feces; HEK293 Cells; High-Throughput Screening Assays; Humans; Ions; Kidney Calculi; Models, Biological; Nanoparticles | 2018 |