arbutin and Breast-Neoplasms

arbutin has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for arbutin and Breast-Neoplasms

Article	Year
The anticarcinogen activity of β-arbutin on MCF-7 cells: Stimulation of apoptosis through estrogen receptor-α signal pathway, inflammation and genotoxicity. Molecular and cellular biochemistry, 2021, Volume: 476, Issue:1 Arbutin is one of the active ingredients employed in cosmetics as a skin whitening agent. In the present study, the possible effects of arbutin on breast cancer were determined with human breast adenocarcinoma (MCF-7) cells. α and β-arbutin cytotoxicity levels in MCF-7 cells were determined with the MTT method. At low (1-10 mM) doses, α-arbutin appears to be more toxic than β-arbutin. At higher (5-200 mM) and LD Topics: Anticarcinogenic Agents; Apoptosis; Arbutin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; DNA Damage; Endoplasmic Reticulum Stress; Estrogen Receptor alpha; Female; Humans; Inflammation; MCF-7 Cells; Micronucleus Tests; Mutagens; Oxidative Stress; Signal Transduction	2021
Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. Journal of medicinal food, 2015, Volume: 18, Issue:3 Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is considered to be safe for medicinal use by the FDA. Pharmacological studies have established the hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, and antioxidant activity of T. diffusa. The aim of the present study was to evaluate the possible cytotoxic effect of extracts and organic fractions of this plant on five tumor cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and normal human fibroblasts. The results show that the methanolic extract (TdM) displayed greater activity on MDA-MB-231 breast cancer cells (with an IC50 of 30.67 μg/mL) than on the other cancer cell lines. Four organic fractions of this extract exhibited activity on this cancer cell line. In the most active fraction (F4), two active compounds were isolated, arbutin (1) and apigenin (2). This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values suggest that the methanolic extract of T. diffusa has potential as an anticancer therapy. Topics: Antineoplastic Agents, Phytogenic; Apigenin; Arbutin; Breast Neoplasms; Cell Line, Tumor; Female; Fibroblasts; Humans; Neoplasms; Phytotherapy; Plant Extracts; Turnera	2015

Article

Year

The anticarcinogen activity of β-arbutin on MCF-7 cells: Stimulation of apoptosis through estrogen receptor-α signal pathway, inflammation and genotoxicity.

Molecular and cellular biochemistry, 2021, Volume: 476, Issue:1

Arbutin is one of the active ingredients employed in cosmetics as a skin whitening agent. In the present study, the possible effects of arbutin on breast cancer were determined with human breast adenocarcinoma (MCF-7) cells. α and β-arbutin cytotoxicity levels in MCF-7 cells were determined with the MTT method. At low (1-10 mM) doses, α-arbutin appears to be more toxic than β-arbutin. At higher (5-200 mM) and LD

Topics: Anticarcinogenic Agents; Apoptosis; Arbutin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; DNA Damage; Endoplasmic Reticulum Stress; Estrogen Receptor alpha; Female; Humans; Inflammation; MCF-7 Cells; Micronucleus Tests; Mutagens; Oxidative Stress; Signal Transduction

2021

Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells.

Journal of medicinal food, 2015, Volume: 18, Issue:3

Turnera diffusa Willd, commonly known as Damiana, is employed in traditional medicine as a stimulant, aphrodisiac, and diuretic. Its leaves and stems are used for flavoring and infusion. Damiana is considered to be safe for medicinal use by the FDA. Pharmacological studies have established the hypoglycemic, antiaromatase, prosexual, estrogenic, antibacterial, and antioxidant activity of T. diffusa. The aim of the present study was to evaluate the possible cytotoxic effect of extracts and organic fractions of this plant on five tumor cell lines (SiHa, C-33, Hep G2, MDA-MB-231, and T-47D) and normal human fibroblasts. The results show that the methanolic extract (TdM) displayed greater activity on MDA-MB-231 breast cancer cells (with an IC50 of 30.67 μg/mL) than on the other cancer cell lines. Four organic fractions of this extract exhibited activity on this cancer cell line. In the most active fraction (F4), two active compounds were isolated, arbutin (1) and apigenin (2). This is the first report of a cytotoxic effect by T. diffusa on cancer cells. The IC50 values suggest that the methanolic extract of T. diffusa has potential as an anticancer therapy.

Topics: Antineoplastic Agents, Phytogenic; Apigenin; Arbutin; Breast Neoplasms; Cell Line, Tumor; Female; Fibroblasts; Humans; Neoplasms; Phytotherapy; Plant Extracts; Turnera

2015