arachidonyltrifluoromethane and Insulinoma

arachidonyltrifluoromethane has been researched along with Insulinoma* in 1 studies

Other Studies

1 other study(ies) available for arachidonyltrifluoromethane and Insulinoma

Article	Year
Effects of arachidonyltrifluoromethyl ketone on cytosolic [Ca2+] in HIT insulinoma cells. Journal of lipid mediators and cell signalling, 1997, Volume: 17, Issue:1 Arachidonyltrifluoromethyl ketone (ATFMK), an analogue of arachidonic acid (AA), inhibits an 85 kDa cytosolic phospholipase A2 enzyme. Exposure of HIT insulinoma cells to ATFMK induced a delayed, sustained, and irreversible increase in cytosolic [Ca2+] that required extracellular Ca2+ and a concentration-dependent inhibition of depolarization-induced increases in cytosolic [Ca2+] prior to onset of the delayed response to AFTMK. These results suggest a disruptive effect of ATFMK on calcium mobilization which may contribute to its effects on insulin secretion from beta-cells. Topics: Animals; Arachidonic Acids; Calcium; Cytosol; Enzyme Inhibitors; Insulinoma; Islets of Langerhans; Potassium Chloride; Tumor Cells, Cultured	1997

Article

Year

Effects of arachidonyltrifluoromethyl ketone on cytosolic [Ca2+] in HIT insulinoma cells.

Journal of lipid mediators and cell signalling, 1997, Volume: 17, Issue:1

Arachidonyltrifluoromethyl ketone (ATFMK), an analogue of arachidonic acid (AA), inhibits an 85 kDa cytosolic phospholipase A2 enzyme. Exposure of HIT insulinoma cells to ATFMK induced a delayed, sustained, and irreversible increase in cytosolic [Ca2+] that required extracellular Ca2+ and a concentration-dependent inhibition of depolarization-induced increases in cytosolic [Ca2+] prior to onset of the delayed response to AFTMK. These results suggest a disruptive effect of ATFMK on calcium mobilization which may contribute to its effects on insulin secretion from beta-cells.

Topics: Animals; Arachidonic Acids; Calcium; Cytosol; Enzyme Inhibitors; Insulinoma; Islets of Langerhans; Potassium Chloride; Tumor Cells, Cultured

1997