arachidin-1 and Triple-Negative-Breast-Neoplasms

arachidin-1 has been researched along with Triple-Negative-Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for arachidin-1 and Triple-Negative-Breast-Neoplasms

Article	Year
Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells. International journal of molecular sciences, 2022, Jan-20, Volume: 23, Issue:3 Triple-negative breast cancer (TNBC) is unresponsive to typical hormonal treatments, causing it to be one of the deadliest forms of breast cancer. Investigating alternative therapies to increase survival rates for this disease is essential. The goal of this study was to assess cytotoxicity and apoptosis mechanisms of prenylated stilbenoids in TNBC cells. The prenylated stilbenoids arachidin-1 (A-1) and arachidin-3 (A-3) are analogs of resveratrol (RES) produced in peanut upon biotic stress. The anticancer activity of A-1 and A-3 isolated from peanut hairy root cultures was determined in TNBC cell lines MDA-MB-231 and MDA-MB-436. After 24 h of treatment, A-1 exhibited higher cytotoxicity than A-3 and RES with approximately 11-fold and six-fold lower IC Topics: Antineoplastic Agents, Phytogenic; Arachis; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Plant Roots; Poly(ADP-ribose) Polymerases; Stilbenes; Triple Negative Breast Neoplasms	2022

Article

Year

Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells.

International journal of molecular sciences, 2022, Jan-20, Volume: 23, Issue:3

Triple-negative breast cancer (TNBC) is unresponsive to typical hormonal treatments, causing it to be one of the deadliest forms of breast cancer. Investigating alternative therapies to increase survival rates for this disease is essential. The goal of this study was to assess cytotoxicity and apoptosis mechanisms of prenylated stilbenoids in TNBC cells. The prenylated stilbenoids arachidin-1 (A-1) and arachidin-3 (A-3) are analogs of resveratrol (RES) produced in peanut upon biotic stress. The anticancer activity of A-1 and A-3 isolated from peanut hairy root cultures was determined in TNBC cell lines MDA-MB-231 and MDA-MB-436. After 24 h of treatment, A-1 exhibited higher cytotoxicity than A-3 and RES with approximately 11-fold and six-fold lower IC

Topics: Antineoplastic Agents, Phytogenic; Arachis; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Plant Roots; Poly(ADP-ribose) Polymerases; Stilbenes; Triple Negative Breast Neoplasms

2022