Compounds > arabinofuranosylcytosine triphosphate

arabinofuranosylcytosine triphosphate and Leukemia, Myeloid, Acute

arabinofuranosylcytosine triphosphate has been researched along with Leukemia, Myeloid, Acute in 63 studies

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-199026 (41.27)18.7374
1990's24 (38.10)18.2507
2000's7 (11.11)29.6817
2010's4 (6.35)24.3611
2020's2 (3.17)2.80

Authors

AuthorsStudies
Alonzo, TA; Aplenc, R; Cao, X; Elsayed, AH; Klco, JM; Kolb, EA; Lamba, JK; Ma, X; Marrero, RJ; Meshinchi, S; Pounds, SB; Ribeiro, RC; Ries, RE; Rubnitz, JE; Wu, H1
Axelsson, H; Branca, RM; Bunten, SS; Coggins, SA; Grandér, D; Hed Myrberg, I; Helleday, T; Henter, JI; Herold, N; Heyman, M; Kim, B; Kutzner, J; Lee, S; Lehmann, S; Lehtiö, J; Lundbäck, T; Mäkelä, P; Mermelekas, G; Paulin, CB; Pokrovskaja Tamm, K; Qian, H; Rassidakis, GZ; Rasti, A; Rudd, SG; Sandhow, L; Sanjiv, K; Schaller, T; Schinazi, RF; Suman, S; Tao, S; Tsesmetzis, N; Walfridsson, J; Warpman-Berglund, U; Wiita, E; Zhang, SM1
Anderson, E; Foulstone, E; Greenwood, R; Heywood, J; Hull, J; Mehta, P; Preston, A; Protheroe, R; Rees, B; Salisbury, V1
Alloush, H; Anderson, E; Conway, M; Fitzgerald, SP; Lamont, J; Martin, A; Mehta, P; O'Malley, K; Reid, C; Ruddock, M; Salisbury, V; Smith, JG; Smith, MA1
Anderson, E; Salisbury, V1
Axelsson, H; Bladh, J; Bulli, L; Calderón-Montaño, JM; Grandér, D; Hagenkort, A; Helleday, T; Henter, JI; Herold, N; Heshmati, Y; Heyman, M; Höglund, A; Jemth, AS; Kogner, P; Kutzner, J; Lehmann, S; Ljungblad, L; Loseva, O; Lundbäck, T; Myrberg, IH; Page, BD; Paulin, CB; Rassidakis, G; Rudd, SG; Sanjiv, K; Schaller, T; Sundin, M; Tamm, KP; Tesi, B; Uhlin, M; Valerie, NC; Walfridsson, J; Warpman-Berglund, U; Wiita, E1
Iwasaki, H; Kishi, S; Negoro, E; Takagi, K; Ueda, T; Urasaki, Y; Yamauchi, T; Yoshida, A1
Lamba, JK1
Behm, FG; Crews, KR; Gandhi, V; Plunkett, W; Pui, CH; Raimondi, SC; Razzouk, BI; Ribeiro, RC; Rubnitz, JE; Srivastava, DK; Stewart, CF; Tong, X1
Biesma, DH; Daenen, SM; Delforge, M; Graveland, WJ; Löwenberg, B; Muus, P; Noordhuis, P; Ossenkoppele, GJ; Peters, GJ; Schaafsma, MR; Selleslag, D; Sonneveld, P; van der Holt, B; Verdonck, LF; Verhoef, GE; Westveer, PH1
Iwasaki, H; Kawai, Y; Kishi, S; Takemura, H; Ueda, T; Urasaki, Y; Yamamoto, S; Yamauchi, T; Yoshida, A1
Crews, K; Gandhi, V; Gresham, J; Lamba, JK; Plunkett, W; Pounds, S; Ribeiro, R; Rubnitz, J; Schuetz, EG1
Egan, EM; Kufe, D; Munroe, D; Spriggs, D1
Grahame-Smith, DG; Harris, AL2
Chubb, S; Hug, V; Keating, MJ; Plunkett, W1
Barlogie, B; Chubb, S; Plunkett, W1
Bunch, C; Grahame-Smith, DG; Harris, AL; Potter, CG1
TAnaka, M; Yoshida, S2
Nakamura, T; Takauji, R; Tohyama, K; Ueda, T1
Barra, Y; Carcassonne, Y; Iliadis, A; Ressayre, C; Riva-Lavieille, C1
Ameling, C; Auf der Landwehr, U; Büchner, T; Hiddemann, W; Reuter, C; Rolf, C; Schleyer, E; Wörmann, B; Zühlsdorf, M1
Tanaka, M1
Bennett, J; Browman, GP; Goldberg, J; Kukla, C; Larson, RA; Miller, KA; Preisler, HD; Raza, A; Rustum, YM; Vogler, R1
Björkholm, M; Gruber, A; Knochenhauer, E; Liliemark, J; Peterson, C; Pettersson, B1
Estey, E; Gandhi, V; Keating, MJ; Plunkett, W1
Estey, EH; Kantarjian, H; Keating, MJ; Plunkett, W; Rios, MB1
Chucrallah, A; Estey, E; Gandhi, V; Keating, MJ; Plunkett, W1
Boos, J; Creutzig, U; Hohenlöchter, B; Jurgens, H; Ritter, J; Schiller, M; Schulze-Westhoff, P; Zimmermann, M1
Nakamura, T; Ueda, T; Yamauchi, T1
Cao, DC; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Komada, Y; Kuwabara, H; Ohkubo, T; Sakurai, M1
Andreeff, HM; Beran, M; Estey, E; Gandhi, V; Kantarjian, HM; Koller, CA; Kornblau, SM; O'Brien, S; Plunkett, W1
Avramis, VI; Kowck, R; Krailo, MD; Liu-Mares, W; Ramilo-Torno, LV; Reaman, GH; Sato, JK; Sharpe, A; Wiersma, S1
Estey, E; Gandhi, V; Xu, YZ1
Fukushima, T; Goto, N; Imamura, S; Iwasaki, H; Kawai, Y; Kishi, S; Masada, M; Tsutani, H; Ueda, T; Urasaki, Y; Yamauchi, T; Yoshida, A1
Preisler, HD; Rustum, YM2
Rustum, YM1
Cadman, E; Eiferman, F1
Gandhi, V; Plunkett, W1
Grant, S; Jarvis, WD; Pettit, GR; Turner, AJ; Wallace, HJ1
Estey, E; Heinemann, V; Keating, M; Plunkett, W1
Kamiya, K; Nakamura, T; Uchida, M; Ueda, T1
Chiba, P; Eher, R; Knapp, W; Köller, U; Kraupp, M; Salamon, J; Szekeres, T; Tihan, T1
Heinemann, V; Jehn, U1
Aul, CH; Büchner, T; Heinecke, A; Hiddemann, W; Maschmeyer, G; Schleyer, E; Uhrmeister, C1
Liliemark, J; Paul, C; Sundman-Engberg, B; Tidefelt, U1
Estey, EH; Freireich, EJ; Keating, MJ; McCredie, KB; Plunkett, W1
Estey, E; Heinemann, V; Keating, MJ; Plunkett, W1
Hirai, J; Itoh, K; Kanno, M; Kobayashi, K; Matsuda, TT; Nakamura, S; Ohtake, S; Yoshida, T1
Iacoboni, S; Keating, MJ; Plunkett, W1
Burke, PJ; Dole, GB; Donehower, RC; Karp, JE1
Adams, TM; Estey, E; Kantarjian, H; Keating, MJ; Liliemark, JO; Nowak, B; Plunkett, W1
Finch, LR; Jamieson, GP; Snook, M; Wiley, JS1
Griffin, JD; Kufe, DW; Spriggs, DR1
Burke, PJ; Donehower, RC; Karp, JE1
Estey, E; Freireich, EJ; Keating, MJ; McCredie, KB; Plunkett, W1
Danhauser, L; Gandhi, V; Iacoboni, S; Keating, M; Liliemark, J; Plunkett, W1
Preisler, HD; Riva, CM; Rustum, YM1
Andersson, B; Beran, M; Estey, E; Freireich, EJ; Iacoboni, S; Kantarjian, H; Keating, MJ; McCredie, KB; Plunkett, W; Walters, R1
Finch, LR; Jamieson, GP; Sawyer, WH; Snook, M; Taupin, J; Wiley, JS1
Kufe, DW; Spriggs, DR1

Reviews

5 review(s) available for arabinofuranosylcytosine triphosphate and Leukemia, Myeloid, Acute

ArticleYear
Genetic factors influencing cytarabine therapy.
    Pharmacogenomics, 2009, Volume: 10, Issue:10

    Topics: 5'-Nucleotidase; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Cytidine Deaminase; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Forecasting; Genetic Variation; Humans; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Pharmacogenetics; Ribonucleotide Reductases

2009
Biochemical modulation of arabinosylcytosine for therapy of leukemias.
    Leukemia & lymphoma, 1993, Volume: 10 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Vidarabine

1993
Pharmacologically directed design of leukemia therapy.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Drug Evaluation; Humans; Leukemia; Leukemia, Myeloid, Acute; Mitoxantrone

1990
Rationales for a pharmacologically optimized treatment of acute nonlymphocytic leukemia with cytosine arabinoside.
    Leukemia, 1990, Volume: 4, Issue:11

    Topics: Arabinofuranosylcytosine Triphosphate; Biological Transport; Cytarabine; Deamination; Drug Administration Schedule; Drug Resistance; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Phosphorylation; Recurrence

1990
Biochemical and cellular pharmacology of cytosine arabinoside.
    Seminars in oncology, 1985, Volume: 12, Issue:2 Suppl 3

    Topics: Animals; Aphidicolin; Arabinofuranosylcytosine Triphosphate; Binding, Competitive; Cell Line; Cell Survival; Centrifugation, Density Gradient; Cytarabine; Diterpenes; DNA; DNA Repair; DNA Replication; Fibroblasts; Granulocytes; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleic Acid Synthesis Inhibitors; Templates, Genetic; Vidarabine

1985

Trials

8 trial(s) available for arabinofuranosylcytosine triphosphate and Leukemia, Myeloid, Acute

ArticleYear
Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia.
    Experimental hematology, 2019, Volume: 74

    Topics: Aged; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Disease-Free Survival; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Remission Induction; Survival Rate; Time Factors

2019
Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Oct-15, Volume: 20, Issue:20

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Child; Child, Preschool; Cladribine; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Remission Induction

2002
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
    Blood, 2004, Apr-15, Volume: 103, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Disease-Free Survival; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Recombinant Proteins; Risk Factors; Survival Rate; Vidarabine

2004
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions.
    Blood, 1996, Jan-01, Volume: 87, Issue:1

    Topics: Adenosine Triphosphate; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Base Sequence; Biotransformation; Cladribine; Cytarabine; DNA Replication; DNA, Neoplasm; Humans; Leukemia, Myeloid, Acute; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; Prodrugs; Ribonucleotide Reductases; Salvage Therapy

1996
Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers.
    Leukemia & lymphoma, 1996, Volume: 22, Issue:3-4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Division; Child; Child, Preschool; Cytarabine; Drug Synergism; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunophenotyping; Infant; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Promyelocytic, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine; Tritium

1996
Clinical and laboratory studies of 2-chlorodeoxyadenosine +/- cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults.
    Leukemia, 1996, Volume: 10, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cladribine; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Recurrence

1996
Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vidarabine

1998
High-dose versus intermediate-dose cytosine arabinoside in combination with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia--preliminary clinical and pharmacological data of a randomized comparison.
    Cancer treatment reviews, 1990, Volume: 17, Issue:2-3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Recurrence

1990

Other Studies

50 other study(ies) available for arabinofuranosylcytosine triphosphate and Leukemia, Myeloid, Acute

ArticleYear
SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
    Blood advances, 2023, 06-13, Volume: 7, Issue:11

    Topics: Arabinofuranosylcytosine Triphosphate; Child; Cytarabine; Humans; Leukemia, Myeloid, Acute; Polymorphism, Single Nucleotide; SAM Domain and HD Domain-Containing Protein 1

2023
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
    EMBO molecular medicine, 2020, 03-06, Volume: 12, Issue:3

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Leukemia, Myeloid, Acute; Mice; Pyrophosphatases; Ribonucleotide Reductases; SAM Domain and HD Domain-Containing Protein 1

2020
Investigation and verification of a bioluminescent biosensor for the quantitation of ara-CTP generation: a biomarker for cytosine arabinoside sensitivity in acute myeloid leukaemia.
    Biosensors & bioelectronics, 2014, Feb-15, Volume: 52

    Topics: Arabinofuranosylcytosine Triphosphate; Biomarkers, Tumor; Biosensing Techniques; Cytarabine; Humans; Leukemia, Myeloid, Acute; Limit of Detection; Luminescent Measurements

2014
Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.
    Advances in biochemical engineering/biotechnology, 2014, Volume: 145

    Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Biological Assay; Biosensing Techniques; Cell Line, Tumor; Cytarabine; Drug Screening Assays, Antitumor; Escherichia coli; Genes, Reporter; Genetic Engineering; Humans; Leukemia, Myeloid, Acute; Limit of Detection; Luciferases, Bacterial; Luminescent Measurements; Operon; Phosphorylation

2014
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinofuranosylcytosine Triphosphate; Child; Child, Preschool; Cytarabine; Disease Models, Animal; Female; Humans; In Vitro Techniques; Infant; Leukemia, Myeloid, Acute; Male; Mice; Molecular Targeted Therapy; Monomeric GTP-Binding Proteins; Prognosis; SAM Domain and HD Domain-Containing Protein 1; Viral Regulatory and Accessory Proteins

2017
Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells.
    Biochemical pharmacology, 2009, Jun-15, Volume: 77, Issue:12

    Topics: 5'-Nucleotidase; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Predictive Value of Tests; RNA, Messenger

2009
Fludarabine-mediated circumvention of cytarabine resistance is associated with fludarabine triphosphate accumulation in cytarabine-resistant leukemic cells.
    International journal of hematology, 2007, Volume: 85, Issue:2

    Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Resistance, Neoplasm; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Vidarabine

2007
Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:3

    Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Blotting, Western; Cell Line, Tumor; Child; Deoxycytidine Kinase; DNA, Complementary; Drug Administration Schedule; Humans; Leukemia, Myeloid, Acute; Linkage Disequilibrium; Pharmacogenetics; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells.
    Blood, 1984, Volume: 64, Issue:1

    Topics: Arabinofuranosylcytosine Triphosphate; Cell Survival; Cytarabine; DNA; Humans; Leukemia, Myeloid, Acute; Tumor Stem Cell Assay

1984
Variation in sensitivity of DNA synthesis to ara-C in acute myeloid leukaemia.
    British journal of haematology, 1980, Volume: 45, Issue:3

    Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cells, Cultured; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute

1980
Quantitation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapy.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Cytarabine; Humans; Leukemia, Myeloid, Acute; Lymphocytes

1980
Simultaneous determination of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and 3-deazauridine 5'-triphosphate in human leukemia cells by high-performance liquid chromatography.
    Journal of chromatography, 1980, Dec-12, Volume: 221, Issue:2

    Topics: 3-Deazauridine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Triphosphate; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Uracil Nucleotides; Uridine; Uridine Triphosphate

1980
Cytosine arabinoside deamination in human leukaemic myeloblasts and resistance to cytosine arabinoside therapy.
    Clinical science (London, England : 1979), 1981, Volume: 60, Issue:2

    Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Bone Marrow; Cells, Cultured; Cytarabine; Deamination; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Tetrahydrouridine

1981
Cytosine arabinoside triphosphate production in human leukaemic myeloblasts: interactions with deoxycytidine.
    Cancer chemotherapy and pharmacology, 1981, Volume: 5, Issue:3

    Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Deoxycytidine; DNA, Neoplasm; Humans; Kinetics; Leukemia, Myeloid, Acute; Phosphorylation; Tetrahydrouridine

1981
Altered sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate of DNA polymerase alpha from leukemic blasts of acute lymphoblastic leukemia.
    Cancer research, 1982, Volume: 42, Issue:2

    Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Drug Resistance; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Nucleic Acid Synthesis Inhibitors

1982
Enhancement of cytosine arabinoside cytotoxicity by granulocyte/macrophage colony-stimulating factor and granulocyte colony-stimulating factor in a human myeloblastic leukemia cell line.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Division; Child; Cytarabine; DNA, Neoplasm; Drug Synergism; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; RNA, Neoplasm; Solubility; Subcellular Fractions; Tumor Cells, Cultured

1993
Calculation of individual dosage regimen of cytosine arabinoside (ara-C) based on metabolite levels in leukemic cells.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:4

    Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute

1994
Modulation of intracellular metabolism of cytosine arabinoside in acute myeloid leukemia by granulocyte-macrophage colony-stimulating factor.
    Leukemia, 1994, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; DNA Polymerase II; DNA-Directed DNA Polymerase; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Middle Aged; S Phase; Thymidine Kinase; Tumor Cells, Cultured

1994
Recombinant GM-CSF modulates the metabolism of cytosine arabinoside in leukemic cells in bone marrow.
    Leukemia research, 1993, Volume: 17, Issue:7

    Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intracellular Fluid; Kinetics; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Recombinant Proteins; S Phase; Tritium; Tumor Cells, Cultured

1993
Long-term outcome of patients with acute myelogenous leukemia: the role of maintenance therapy, consolidation therapy and the predictive value of two in vitro assays.
    Leukemia & lymphoma, 1993, Volume: 10, Issue:1-2

    Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Predictive Value of Tests; Prognosis; Recurrence; Remission Induction; Treatment Outcome; Tumor Stem Cell Assay

1993
On the interaction between cytosine arabinoside and etoposide in vivo and in vitro.
    European journal of haematology, 1993, Volume: 50, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Interactions; Etoposide; Humans; In Vitro Techniques; Kinetics; Leukemia, Myeloid, Acute; Phosphorylation

1993
Treatment of relapsed or refractory AML with intermediate-dose arabinosylcytosine (ara-C): confirmation of the importance of ara-C triphosphate formation in mediating response to ara-C.
    Leukemia & lymphoma, 1993, Volume: 10 Suppl

    Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Clinical Protocols; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute; Middle Aged; Recurrence; Remission Induction

1993
Intracellular retention of cytosine arabinoside triphosphate in blast cells from children with acute myelogenous and lymphoblastic leukemia.
    Medical and pediatric oncology, 1996, Volume: 26, Issue:6

    Topics: Adolescent; Arabinofuranosylcytosine Triphosphate; Blood Cells; Bone Marrow; Burkitt Lymphoma; Cells, Cultured; Child; Child, Preschool; Culture Media; Drug Administration Schedule; Drug Monitoring; Humans; Immunophenotyping; Infusions, Intravenous; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid, Acute; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
A new sensitive method for determination of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate content in human materials in vivo.
    Cancer research, 1996, Apr-15, Volume: 56, Issue:8

    Topics: Alkaline Phosphatase; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytarabine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Radioimmunoassay; Sensitivity and Specificity; Tumor Cells, Cultured

1996
Accumulation of arabinosyluracil 5'-triphosphate during arabinosylcytosine therapy in circulating blasts of patients with acute myelogenous leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:7

    Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia, Myeloid, Acute; Uridine Triphosphate

1998
Monitoring of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in 1-beta-D-arabinofuranosylcytosine therapy at low and conventional doses.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arabinofuranosylcytosine Triphosphate; Cytarabine; Female; Half-Life; Humans; Infusions, Intravenous; Injections, Subcutaneous; Kinetics; Leukemia, Myeloid, Acute; Male; Middle Aged

2001
Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy.
    Cancer research, 1979, Volume: 39, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Cytarabine; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Male; Middle Aged; Remission, Spontaneous; Time Factors

1979
Multiple determinants of antimetabolite action in humans.
    Bulletin du cancer, 1979, Volume: 66, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Deamination; DNA; Doxorubicin; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Neoplasms, Experimental

1979
Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.
    The Journal of clinical investigation, 1979, Volume: 64, Issue:3

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Drug Synergism; Humans; In Vitro Techniques; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice

1979
Prediction of therapeutic response in acute myelocytic leukemia.
    Haematology and blood transfusion, 1979, Volume: 23

    Topics: Arabinofuranosylcytosine Triphosphate; Benzimidazoles; Biological Transport; Cytarabine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Fluorescence; Fluorescent Dyes; Humans; Leukemia, Myeloid, Acute; Phosphorylation

1979
Cell cycle-specific metabolism of arabinosyl nucleosides in K562 human leukemia cells.
    Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:1

    Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Cycle; Cytarabine; Deoxycytidine Kinase; Drug Synergism; G1 Phase; G2 Phase; Humans; Intracellular Fluid; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Metaphase; Nucleotides; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Vidarabine

1992
Effects of bryostatin 1 and rGM-CSF on the metabolism of 1-beta-D-arabinofuranosylcytosine in human leukaemic myeloblasts.
    British journal of haematology, 1992, Volume: 82, Issue:3

    Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cytarabine; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Recombinant Proteins; Time Factors

1992
[Studies on intracellular kinetics of ara-C triphosphate in HL-60, human leukemia cells in relation to reasonable administration of ara-C].
    Nihon Gan Chiryo Gakkai shi, 1990, Jul-20, Volume: 25, Issue:7

    Topics: Arabinofuranosylcytosine Triphosphate; Biological Transport, Active; Biotransformation; Cytarabine; Humans; Leukemia, Myeloid, Acute; Tumor Cells, Cultured

1990
Concordant changes of pyrimidine metabolism in blasts of two cases of acute myeloid leukemia after repeated treatment with ara-C in vivo.
    Leukemia, 1990, Volume: 4, Issue:11

    Topics: Adolescent; Adult; Arabinofuranosylcytosine Triphosphate; Cytarabine; DCMP Deaminase; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Drug Resistance; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyrimidines; Thymine Nucleotides

1990
Intracellular concentrations of anti cancer drugs in leukemic cells in vitro vs in vivo.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Humans; Leukemia, Myeloid, Acute; Middle Aged; Tumor Cells, Cultured

1990
Cellular ara-CTP pharmacokinetics, response, and karyotype in newly diagnosed acute myelogenous leukemia.
    Leukemia, 1990, Volume: 4, Issue:2

    Topics: Amsacrine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Chromosome Deletion; Chromosome Inversion; Cytarabine; Drug Resistance; Humans; Karyotyping; Leukemia, Myeloid, Acute

1990
Efficient formation of cytosine arabinoside-5'-triphosphate in leukemic blasts of human T-cell acute lymphoblastic leukemia.
    Leukemia research, 1989, Volume: 13, Issue:10

    Topics: Adolescent; Adult; Antigens, CD; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Interphase; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone

1989
Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:5

    Topics: Adult; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Administration Schedule; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged

1989
[Relation between plasma Ara-C and intracellular Ara-CTP levels by intermediate dose and high dose Ara-C administration in the treatment of AML].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 1

    Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Bone Marrow Cells; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged

1988
Cellular pharmacology and optimal therapeutic concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-beta-D-arabinofuranosylcytosine.
    Scandinavian journal of haematology. Supplementum, 1986, Volume: 44

    Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biotransformation; Chromatography, High Pressure Liquid; Cytarabine; Humans; Kinetics; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

1986
Correlation of drug-perturbed marrow cell growth kinetics and intracellular 1-B-D-arabinofuranosylcytosine metabolism with clinical response in adult acute myelogenous leukemia.
    Blood, 1987, Volume: 69, Issue:4

    Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cells, Cultured; Cytarabine; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Prognosis

1987
Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapy.
    Cancer research, 1987, Jun-01, Volume: 47, Issue:11

    Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Blast Crisis; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Metabolic Clearance Rate

1987
Degradation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human leukemic myeloblasts and lymphoblasts.
    Cancer research, 1987, Jun-15, Volume: 47, Issue:12

    Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DCMP Deaminase; Guanosine; Half-Life; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Phosphorylation; Thioinosine; Thionucleosides

1987
Pharmacologic studies of low-dose and high-dose continuous infusion cytosine arabinoside.
    Seminars in oncology, 1987, Volume: 14, Issue:2 Suppl 1

    Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Replicon; Thrombocytopenia

1987
An in vitro model to predict clinical response in adult acute myelogenous leukemia.
    Seminars in oncology, 1987, Volume: 14, Issue:2 Suppl 1

    Topics: Adult; Arabinofuranosylcytosine Triphosphate; Blood; Bone Marrow; Cell Cycle; Cells, Cultured; Culture Media; Cytarabine; DNA, Neoplasm; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Time Factors

1987
Continuous infusion high-dose cytosine arabinoside without anthracyclines as induction and intensification therapy in adults under age 50 with newly diagnosed acute myelogenous leukemia.
    Seminars in oncology, 1987, Volume: 14, Issue:2 Suppl 1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Translocation, Genetic; Vincristine

1987
Comparison between the plasma and intracellular pharmacology of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate in patients with relapsed leukemia.
    Leukemia, 1987, Volume: 1, Issue:9

    Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DNA Replication; Drug Evaluation; Female; Half-Life; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Recurrence; Vidarabine

1987
Pharmacokinetics and cellular determinants of response to 1-beta-arabinofuranosylcytosine (ara-C).
    Seminars in oncology, 1985, Volume: 12, Issue:2 Suppl 3

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice; Mice, Inbred DBA

1985
Evolution of clinical studies with high-dose cytosine arabinoside at the M.D. Anderson Hospital.
    Seminars in oncology, 1985, Volume: 12, Issue:2 Suppl 3

    Topics: Arabinofuranosylcytosine Triphosphate; Chromosome Aberrations; Cytarabine; Drug Evaluation; Drug Resistance; Half-Life; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Prognosis; Time Factors

1985
Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:2

    Topics: Adolescent; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Biological Transport, Active; Biotransformation; Child; Child, Preschool; Cytarabine; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Middle Aged; T-Lymphocytes

1985