arabinofuranosylcytosine triphosphate has been researched along with Leucocythaemia in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (66.67) | 18.7374 |
| 1990's | 17 (26.98) | 18.2507 |
| 2000's | 3 (4.76) | 29.6817 |
| 2010's | 1 (1.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alloush, H; Anderson, E; Conway, M; Lamont, J; Martin, A; Mehta, P; Ruddock, M; Salisbury, V; Smith, JG; Smith, MA | 1 |
| Dai, Y; Decker, RH; Grant, S; Kramer, LB; Levin, J | 1 |
| Bowman, WP; Danks, MK; Look, AT; Ochs, J; Rivera, G; Sinkule, JA | 1 |
| Howell, SB; Pfeifle, CE; Streifel, JA | 1 |
| Barlogie, B; Chubb, S; Plunkett, W | 1 |
| Abe, I; Hori, K; Saito, S; Sato, H; Suzuki, M | 1 |
| Drenthe-Schonk, A; Haanen, C; Linssen, P; Vierwinden, G; Wessels, H | 1 |
| Danks, MK | 1 |
| Bakshi, D; Buscaglia, D; Early, AP; Kelly, E; Preisler, H; Rustum, YM; Slocum, HK; Wang, G; Wrzosek, C | 1 |
| Estey, E; Gandhi, V; Plunkett, W | 1 |
| Horber, DH; Schott, H; Schwendener, RA | 1 |
| Avramis, VI; Ramilo-Torno, LV | 1 |
| Estey, E; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Kasperrs, GJ; Kazemier, KM; Noordhuis, P; Peters, GJ | 1 |
| Estey, EH; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Cao, DC; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Sakurai, M; Shindou, K | 1 |
| Heinemann, V; Issels, RD; Schulz, L; Wilmanns, W | 1 |
| Rowe, JM | 1 |
| Ahlmann, M; Baumann, M; Boos, J; Freund, A; Lanvers, C; Lümkemann, K; Rössig, C | 1 |
| Smyth, JF | 1 |
| Busch, FW; Ehninger, G; Hiddemann, W; Jaschonek, K; Proksch, B; Schleyer, E; Schmidt, H; Schuler, U; Wanner, T | 1 |
| Catapano, CV; Chandler, KB; Fernandes, DJ | 1 |
| Chiba, P; Jäger, W; Szekeres, T | 1 |
| Bhalla, K; Grant, S; McCrady, C | 1 |
| Boos, J | 1 |
| Hashimoto, H; Kubota, M; Mikawa, H; Shimizu, T; Yorifuji, T | 1 |
| Arentsen-Honders, MW; Colly, LP; Richel, DJ; Starrenburg, CW; Willemze, R | 1 |
| Estey, E; Heinemann, V; Keating, M; Plunkett, W | 1 |
| Jamieson, GP; Snook, MB; Wiley, JS | 1 |
| Fridland, A; Verhoef, V | 1 |
| Cabanillas, F; Danhauser, L; Keating, M; Plunkett, W | 1 |
| Akiyama, Y; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Gandhi, V; Plunkett, W | 2 |
| Akiyama, Y; Kiriyama, Y; Kitoh, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Ehninger, G; Hiddemann, W; Proksch, B; Schleyer, E; Zühlsdorf, M | 1 |
| David, JC; Maniey, D; Marquet, J; Zittoun, J; Zittoun, R | 1 |
| Mitchell, BS; Shewach, DS | 1 |
| Tanaka, M; Yoshida, S | 1 |
| Iacoboni, S; Keating, MJ; Plunkett, W | 1 |
| Adams, TM; Estey, E; Kantarjian, H; Keating, MJ; Liliemark, JO; Nowak, B; Plunkett, W | 1 |
| Danhauser, L; Gandhi, V; Iacoboni, S; Keating, M; Liliemark, J; Plunkett, W | 1 |
| Avramis, VI; Biener, R; Ettinger, L; Finklestein, J; Holcenberg, JS; Krailo, M; Siegel, SE; Willoughby, M | 1 |
| Liliemark, JO; Plunkett, W | 1 |
| Keating, MJ; Nowak, B; Plunkett, W | 1 |
| Preisler, HD; Riva, C; Rustum, YM | 1 |
| Estey, E; Keating, MJ; Liliemark, JO; Plunkett, W | 1 |
| Gahrton, G; Liliemark, JO; Paul, CY; Peterson, CO | 1 |
| Akman, SA; Joneckis, CC; Ross, DD; Schiffer, CA; Thompson, BW | 2 |
| Keating, M; Plunkett, W | 1 |
| Azarnia, N; Preisler, HD; Priore, R; Rustum, YM | 1 |
| Preisler, HD; Riva, CM; Rustum, YM | 1 |
| Andersson, B; Beran, M; Estey, E; Freireich, EJ; Iacoboni, S; Kantarjian, H; Keating, MJ; McCredie, KB; Plunkett, W; Walters, R | 1 |
| Finch, LR; Jamieson, GP; Sawyer, WH; Snook, M; Taupin, J; Wiley, JS | 1 |
| Capizzi, RL; Cooper, MR; Jackson, DV; Muss, HB; Powell, BL; Richards, F; Spurr, CL; Stuart, JJ; White, DR; Zekan, PJ | 1 |
| Drenthe-Schonk, A; Haanen, C; Muus, P; Raymakers, R; Salden, M; Wessels, J | 1 |
| Edelstein, M; Valeriote, F | 1 |
| Gahrton, CG; Liliemark, JO; Paul, CY; Peterson, CO | 1 |
| Danhauser, L; Estey, E; Iacoboni, S; Keating, MJ; Liliemark, JO; Plunkett, W | 1 |
| Browman, G; Preisler, HD; Raza, A; Rustum, Y | 1 |
| Preisler, HD; Priore, RL; Rustum, Y | 1 |
| Dixon, DO; Liliemark, JO; Plunkett, W | 1 |
8 review(s) available for arabinofuranosylcytosine triphosphate and Leucocythaemia
| Article | Year |
|---|---|
Modulation of arabinosylcytosine metabolism during leukemia therapy.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Biotransformation; Cytarabine; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Vidarabine | 1994 |
Biochemical modulation of arabinosylcytosine for therapy of leukemias.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Vidarabine | 1993 |
Intracellular pharmacodynamics in leukemia therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia; Mitoxantrone; Vidarabine | 1996 |
Concurrent use of growth factors and chemotherapy in acute leukemia.
Topics: Acute Disease; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Clinical Trials as Topic; Colony-Stimulating Factors; Growth Substances; Humans; Leukemia | 2000 |
Pharmacologically directed design of leukemia therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Drug Evaluation; Humans; Leukemia; Leukemia, Myeloid, Acute; Mitoxantrone | 1990 |
Sequential high-dose ara-C and asparaginase in the therapy of previously treated and untreated patients with acute leukemia.
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Asparaginase; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Middle Aged; Time Factors | 1985 |
Studies on the cytotoxicity of cytosine arabinoside.
Topics: Adolescent; Adult; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cell Cycle; Cell Differentiation; Cells, Cultured; Clone Cells; Colony-Forming Units Assay; Cytarabine; DNA; Drug Resistance; Female; Granulocytes; Half-Life; Humans; Interphase; Kinetics; Leukemia; Male; Middle Aged; Phosphorylation; Recurrence | 1985 |
Cytosine arabinoside in experimental combination therapy.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cisplatin; Cyclophosphamide; Cytarabine; Daunorubicin; DNA; DNA Repair; Doxorubicin; Drug Interactions; Drug Resistance; Humans; Interphase; Leukemia; Mercaptopurine; Phosphorylation; Thioguanine; Thymidine; Time Factors | 1985 |
2 trial(s) available for arabinofuranosylcytosine triphosphate and Leucocythaemia
| Article | Year |
|---|---|
Effect of amsacrine on ara-CTP cellular pharmacology in human leukemia cells during high-dose cytarabine therapy.
Topics: Acute Disease; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged | 1987 |
Sequential high-dose ara-C and asparaginase in the therapy of previously treated and untreated patients with acute leukemia.
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Asparaginase; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Middle Aged; Time Factors | 1985 |
54 other study(ies) available for arabinofuranosylcytosine triphosphate and Leucocythaemia
| Article | Year |
|---|---|
A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinofuranosylcytosine Triphosphate; Bacterial Proteins; Biosensing Techniques; Cell Line, Tumor; Cytarabine; HL-60 Cells; Humans; K562 Cells; Leukemia; Luminescent Measurements; Luminescent Proteins; Treatment Outcome; Vidarabine | 2013 |
Enforced expression of the tumor suppressor p53 renders human leukemia cells (U937) more sensitive to 1-[beta-D-arabinofuranosyl]cytosine (ara-C)-induced apoptosis.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Arabinofuranosylcytosine Triphosphate; Cytarabine; Genes, p53; Genes, Tumor Suppressor; Humans; Leukemia; U937 Cells | 2003 |
Continuous infusion high-dose cytosine arabinoside in refractory childhood leukemia.
Topics: Acute Disease; Adolescent; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Child; Child, Preschool; Cytarabine; Deoxycytosine Nucleotides; Drug Administration Schedule; Humans; Infusions, Parenteral; Kinetics; Leukemia; Leukemia, Lymphoid | 1984 |
Modulation of the cellular pharmacology and clinical toxicity of 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Line; Cytarabine; Deoxyribonucleotides; DNA; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia; Ribonucleotide Reductases; Ribonucleotides; Thymidine | 1982 |
Simultaneous determination of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and 3-deazauridine 5'-triphosphate in human leukemia cells by high-performance liquid chromatography.
Topics: 3-Deazauridine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Triphosphate; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1980 |
Role of dephosphorylation in accumulation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human lymphoblastic cell lines with reference to their drug sensitivity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Division; Cell Line; Cells, Cultured; Cytarabine; DNA, Neoplasm; Humans; Hydroxyurea; Leukemia; Lymphoma; Phosphorylation; Thymidine | 1982 |
Determination of cytosine arabinoside triphosphate in leukemic cells by isocratic high-performance anion-exchange column chromatography.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Leukemia; Time Factors | 1982 |
Two simple high-performance liquid chromatographic methods for simultaneous determination of 2'-deoxycytidine 5'-triphosphate and cytosine arabinoside 5'-triphosphate concentrations in biological samples.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Child; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytosine Nucleotides; Humans; Leukemia; Spectrophotometry, Ultraviolet | 1982 |
Relationship between plasma Ara-C and intracellular Ara-CTP pools under conditions of continuous infusion and high-dose Ara-C treatment.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia | 1982 |
Cellular pharmacology of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Differentiation; Cytarabine; Dipyridamole; DNA; Drug Carriers; Drug Interactions; Half-Life; Humans; Leukemia; Liposomes; Tumor Cells, Cultured | 1995 |
Intracellular pharmacodynamic studies of the synergistic combination of 6-mercaptopurine and cytosine arabinoside in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cell Survival; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Kinetics; Leukemia; Mercaptopurine; Tumor Cells, Cultured | 1995 |
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cytarabine; Cytidine Triphosphate; DNA, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Phosphonoacetic Acid; Tumor Cells, Cultured; Uridine Triphosphate | 1996 |
Deoxycytidine kinase mRNA levels in leukemia cells with competitive polymerase chain reaction assay.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Deoxycytidine Kinase; Humans; Leukemia; Leukemia, Myeloid; Nucleic Acid Synthesis Inhibitors; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Transcription, Genetic | 1996 |
Regulation of deoxycytidine kinase by deoxycytidine and deoxycytidine 5' triphosphate in whole leukemia and tumor cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; CHO Cells; Cricetinae; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; HL-60 Cells; Homeostasis; Humans; Leukemia; Ribonucleotide Reductases; Tumor Cells, Cultured | 1998 |
Modulation of ara-CTP levels by fludarabine and hydroxyurea in leukemic cells.
Topics: Adult; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; HL-60 Cells; Humans; Hydroxyurea; Leukemia; Vidarabine | 2001 |
Biochemical determinants for antileukemia drug treatment.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Arabinofuranosylcytosine Triphosphate; Coformycin; Cytarabine; Humans; Leukemia; Methotrexate; Pentostatin; Phosphorylation; Tissue Distribution | 1979 |
Intracellular cytosine arabinoside accumulation and cytosine arabinoside triphosphate formation in leukemic blast cells is inhibited by etoposide and teniposide.
Topics: Acute Disease; Adult; Aged; Amsacrine; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Interactions; Etoposide; Humans; Leukemia; Middle Aged; Neoplastic Stem Cells; Phosphorylation; Teniposide; Tumor Cells, Cultured | 1992 |
Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate.
Topics: Aphidicolin; Arabinofuranosylcytosine Triphosphate; Deoxyguanine Nucleotides; Diterpenes; DNA Primase; DNA-Directed DNA Polymerase; DNA, Neoplasm; Humans; Leukemia; RNA; RNA Nucleotidyltransferases; Tumor Cells, Cultured; Vidarabine Phosphate | 1991 |
Determination of pyrimidine deoxynucleoside triphosphates in leukaemia cell extracts containing 1-beta-D-arabinofuranosylcytosine triphosphate.
Topics: Adenosine Triphosphate; Arabinofuranosylcytosine Triphosphate; Cell Line; Chromatography, High Pressure Liquid; Cytidine Triphosphate; Deoxyribonucleotides; Guanosine Triphosphate; Humans; Leukemia; Ribonucleotides; Thymine Nucleotides; Uridine Triphosphate | 1991 |
Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Cytidine Deaminase; DCMP Deaminase; Deamination; Deoxycytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; Leukemia; Tetrahydrouridine; Tumor Cells, Cultured | 1991 |
A simple isocratic ion-pair high-performance liquid chromatographic determination of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate for intracellular drug-monitoring and in vitro incubation assays.
Topics: Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Humans; Leukemia; Tartrates; Tumor Cells, Cultured | 1991 |
Metabolism and toxicity of electroporated 1-beta-D-arabinofuranosylcytosine triphosphate in a human leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Buffers; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Electricity; Humans; Leukemia; Nucleosides; Tumor Cells, Cultured | 1990 |
Deoxycytidine kinase, thymidine kinase and cytidine deaminase and the formation of Ara-CTP in leukemic cells in different phases of the cell cycle.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Cycle; Deoxycytidine Kinase; DNA, Neoplasm; Humans; Leukemia; Phosphotransferases; Rats; Thymidine Kinase; Tumor Cells, Cultured; Uridine Kinase | 1990 |
Saturation of intracellular cytosine arabinoside triphosphate accumulation in human leukemic blast cells.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Binding Sites; Biological Transport; Cell Membrane; Cytarabine; Deoxycytidine Kinase; Extracellular Space; Humans; Leukemia; Lymphocytes; Nucleosides; Phosphorylation; Thioinosine; Tumor Cells, Cultured | 1990 |
Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; B-Lymphocytes; Cell Line; Cell Survival; Cytarabine; Deoxyguanosine; Humans; Leukemia; Phosphorylation; T-Lymphocytes; Vidarabine; Vidarabine Phosphate | 1985 |
9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; DNA; Humans; Kinetics; Leukemia; Lymphoma; Vidarabine Phosphate | 1986 |
Differential modulation of 1-beta-D-arabinofuranosylcytosine metabolism by hydroxyurea in human leukemic cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; B-Lymphocytes; Cell Line; Cytarabine; Deoxyadenine Nucleotides; Deoxyadenosines; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Hydroxyurea; Leukemia; T-Lymphocytes; Thymine Nucleotides; Vidarabine Phosphate | 1988 |
Interaction of arabinosyl nucleotides in K562 human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; Arabinonucleotides; Cytarabine; Deoxyribonucleotides; Drug Interactions; Guanosine Triphosphate; Humans; Leukemia; Phosphorylation; Phosphotransferases; Tumor Cells, Cultured; Vidarabine; Vidarabine Phosphate | 1989 |
Ara-CTP metabolism following hydroxyurea or methotrexate treatment in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Drug Synergism; Humans; Hydroxyurea; Leukemia; Leukemia, Promyelocytic, Acute; Methotrexate; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Detection and separation of intracellular 1-beta-D-arabinofuranosylcytosine-5-triphosphate by ion-pair high-performance liquid chromatography.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Chromatography, High Pressure Liquid; Humans; Leukemia; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured | 1989 |
A study of the mechanisms of cytotoxicity of Ara-C on three human leukemic cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; DNA; DNA Ligases; DNA Polymerase II; DNA, Neoplasm; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; Arabinonucleotides; Cell Division; Cytarabine; Guanine; Humans; In Vitro Techniques; Leukemia; T-Lymphocytes; Tumor Cells, Cultured | 1989 |
Formation of cytosine arabinoside-5'-triphosphate in cultured human leukemic cell lines correlates with nucleoside transport capacity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biological Transport; Cell Line; Cell Membrane; Cytarabine; Humans; Leukemia | 1987 |
Modulation of arabinosylnucleoside metabolism by arabinosylnucleotides in human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Leukemia; Phosphorylation; Tumor Cells, Cultured; Vidarabine | 1988 |
Cellular pharmacology and optimal therapeutic concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-beta-D-arabinofuranosylcytosine.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biotransformation; Chromatography, High Pressure Liquid; Cytarabine; Humans; Kinetics; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute | 1986 |
Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapy.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Blast Crisis; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Metabolic Clearance Rate | 1987 |
Comparison between the plasma and intracellular pharmacology of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate in patients with relapsed leukemia.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DNA Replication; Drug Evaluation; Female; Half-Life; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Recurrence; Vidarabine | 1987 |
Biochemical pharmacology of high dose 1-beta-D-arabinofuranosylcytosine in childhood acute leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Child; Cytarabine; Half-Life; Humans; Leukemia; Leukemia, Lymphoid; Neutropenia | 1987 |
Regulation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in human leukemia cells by deoxycytidine 5'-triphosphate.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Cycle; Cell Line; Cytarabine; Deoxycytosine Nucleotides; Humans; Interphase; Leukemia; Nucleotides; Phosphorylation; T-Lymphocytes | 1986 |
Pharmacokinetic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) and their relationship to intracellular metabolism of ara-C, toxicity, and response of patients with acute nonlymphocytic leukemia treated with conventional and high-dose ara-C.
Topics: Acute Disease; Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Drug Administration Schedule; Humans; Leukemia; Leukemia L1210; Metabolic Clearance Rate; Mice; Uridine Kinase | 1987 |
Saturation of ara-CTP accumulation during high-dose ara-C therapy: pharmacologic rationale for intermediate-dose ara-C.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Leukemia; Metabolic Clearance Rate | 1987 |
ara-C in plasma and ara-CTP in leukemic cells after subcutaneous injection and continuous intravenous infusion of ara-C in patients with acute nonlymphoblastic leukemia.
Topics: Acute Disease; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Leukemia; Male; Metabolic Clearance Rate; Middle Aged | 1987 |
Studies of ara-C metabolism in acute leukemia.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Bromodeoxyuridine; Cell Line; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Thymidine | 1987 |
Metabolism of ara-C by blast cells from patients with ANLL.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Leukemia; Male; Middle Aged | 1986 |
Effect of m-AMSA on the cellular pharmacology of ara-CTP in human leukemic cells during therapy with high-dose ara-C.
Topics: Amsacrine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia; Metabolic Clearance Rate | 1986 |
Abrogation of the prognostic significance of low leukemic cell retention of cytosine arabinoside triphosphate by intensification of therapy and by alteration in the dose and schedule of administration of cytosine arabinoside.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Doxorubicin; Humans; Leukemia; Middle Aged; Neoplasm Proteins; Phosphorylation; Prognosis | 1987 |
Pharmacokinetics and cellular determinants of response to 1-beta-arabinofuranosylcytosine (ara-C).
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice; Mice, Inbred DBA | 1985 |
Evolution of clinical studies with high-dose cytosine arabinoside at the M.D. Anderson Hospital.
Topics: Arabinofuranosylcytosine Triphosphate; Chromosome Aberrations; Cytarabine; Drug Evaluation; Drug Resistance; Half-Life; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Prognosis; Time Factors | 1985 |
Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma.
Topics: Adolescent; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Biological Transport, Active; Biotransformation; Child; Child, Preschool; Cytarabine; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Middle Aged; T-Lymphocytes | 1985 |
Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic cells after intravenous and subcutaneous administration of 1-beta-D-arabinofuranosylcytosine.
Topics: Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Injections, Intravenous; Injections, Subcutaneous; Kinetics; Leukemia; Male; Middle Aged; Phosphorylation | 1985 |
Pharmacologically directed ara-C therapy for refractory leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DNA; Drug Resistance; Humans; Kinetics; Leukemia | 1985 |
The treatment of patients with acute nonlymphocytic leukemia in remission.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Kinetics; Leukemia; Prognosis; Recurrence; Time Factors | 1985 |
Relationship between leukemic cell retention of cytosine arabinoside triphosphate and the duration of remission in patients with acute non-lymphocytic leukemia.
Topics: Acute Disease; Adult; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Phosphorylation; Time Factors | 1985 |
Relationship of 1-beta-D-arabinofuranosylcytosine in plasma to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate levels in leukemic cells during treatment with high-dose 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Kinetics; Leukemia | 1985 |