apyrase and Stomach-Neoplasms

apyrase has been researched along with Stomach-Neoplasms* in 3 studies

Reviews

1 review(s) available for apyrase and Stomach-Neoplasms

Article	Year
Adenosine signaling: Next checkpoint for gastric cancer immunotherapy? International immunopharmacology, 2018, Volume: 63 Adenosine (ADO), generated by the ectonucleotidase CD39 and CD73 from ATP, interacts with its specific G protein-coupled receptors, which can impair anti-tumor immune responses inhibiting the infiltration and function of CD8 Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; Humans; Immunotherapy; Receptors, Purinergic P1; Signal Transduction; Stomach Neoplasms	2018

Article

Year

Adenosine signaling: Next checkpoint for gastric cancer immunotherapy?

International immunopharmacology, 2018, Volume: 63

Adenosine (ADO), generated by the ectonucleotidase CD39 and CD73 from ATP, interacts with its specific G protein-coupled receptors, which can impair anti-tumor immune responses inhibiting the infiltration and function of CD8

Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; Humans; Immunotherapy; Receptors, Purinergic P1; Signal Transduction; Stomach Neoplasms

2018

Other Studies

2 other study(ies) available for apyrase and Stomach-Neoplasms

Article	Year
Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nature communications, 2018, 08-24, Volume: 9, Issue:1 Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. Krt76 Topics: 5'-Nucleotidase; Animals; Antigens, CD; Apyrase; Cell Line, Tumor; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; In Situ Hybridization, Fluorescence; In Vitro Techniques; Keratins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mouth Neoplasms; Stomach Neoplasms; T-Lymphocytes, Regulatory	2018
Overexpression of CD39 and high tumoral CD39⁺/CD8⁺ ratio are associated with adverse prognosis in resectable gastric cancer. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:11 CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) is a cell surface-located, rate-limiting enzyme in the generation of adenosine, and plays a crucial role in tumor development. We examined co-expression of CD39 and CD8in gastric cancer (GC) and showed that the expression of CD39 and CD8 increased significantly in tumor tissues compared to paired peritumor tissues. The expression of tumoral CD39 (tCD39), but not tumoral CD8 (tCD8), was related to overall survival. Furthermore, the CD39(+)/CD8(+) ratio was associated with poor prognosis in resected GC patients. Taken together, our data indicate that highCD39 expression and high tCD39(+)/CD8(+) ratio in GC is a predictor of poor prognosis for GC patients after radical resection. Moreover, CD39 could serve as a potential target for cancer immunotherapy. Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Apyrase; Biomarkers, Tumor; CD8 Antigens; CD8-Positive T-Lymphocytes; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Prognosis; Proportional Hazards Models; Stomach Neoplasms	2015

Article

Year

Immunomodulatory role of Keratin 76 in oral and gastric cancer.

Nature communications, 2018, 08-24, Volume: 9, Issue:1

Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis. We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. Krt76

Topics: 5'-Nucleotidase; Animals; Antigens, CD; Apyrase; Cell Line, Tumor; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; In Situ Hybridization, Fluorescence; In Vitro Techniques; Keratins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mouth Neoplasms; Stomach Neoplasms; T-Lymphocytes, Regulatory

2018

Overexpression of CD39 and high tumoral CD39⁺/CD8⁺ ratio are associated with adverse prognosis in resectable gastric cancer.

International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:11

CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) is a cell surface-located, rate-limiting enzyme in the generation of adenosine, and plays a crucial role in tumor development. We examined co-expression of CD39 and CD8in gastric cancer (GC) and showed that the expression of CD39 and CD8 increased significantly in tumor tissues compared to paired peritumor tissues. The expression of tumoral CD39 (tCD39), but not tumoral CD8 (tCD8), was related to overall survival. Furthermore, the CD39(+)/CD8(+) ratio was associated with poor prognosis in resected GC patients. Taken together, our data indicate that highCD39 expression and high tCD39(+)/CD8(+) ratio in GC is a predictor of poor prognosis for GC patients after radical resection. Moreover, CD39 could serve as a potential target for cancer immunotherapy.

Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Apyrase; Biomarkers, Tumor; CD8 Antigens; CD8-Positive T-Lymphocytes; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Prognosis; Proportional Hazards Models; Stomach Neoplasms

2015