apyrase and Purpura--Thrombocytopenic--Idiopathic

Primary immune thrombocytopenia is an autoimmune disease, characterized with decreased platelet and increased risk of bleeding. Recent studies have shown the reduction and dysfunction of regulatory T (Treg) cells in ITP patients. CD39 is highly expressed on the surface of Treg cells. It degrades ATP to AMP and CD73 dephosphorylates AMP into adenosine. Then adenosine binds with adenosine receptor and suppresses immune response by activating Treg cells and inhibiting the release of inflammatory cytokines from effector T (Teff) cells. Adenosine receptor has several subtypes and adenosine A2A receptor (A2AR) plays a crucial role especially within lymphocytes. The CD39

Topics: Adenosine; Adenosine Triphosphate; Adult; Aged; Apyrase; Case-Control Studies; Dexamethasone; Female; Gene Expression; Humans; Immunophenotyping; Immunosuppressive Agents; Lymphocyte Count; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopathic; Receptor, Adenosine A2A; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory