apyrase and Proteinuria

In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular inflammation in pregnant rats infused with low-dose endotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endotoxin (ET rats) or saline (control rats) and received ASA in their drinking water. These rats were compared with non-ASA-treated rats. Blood pressure and albumin excretion were measured from day 15 to day 21, and glomerular fibrinogen and ecto-ADPase activity were measured at day 21. Glomerular inflammation was evaluated at various times after the start of the infusion. The results show that treatment with ASA had a significant beneficial effect on hypertension and inflammation induced by endotoxin in pregnant rats, whereas it reduced albumin excretion and glomerular fibrinogen deposits in some of the rats.

Topics: Albuminuria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apyrase; Aspirin; Blood Pressure; Cell Adhesion Molecules; Endotoxins; Female; Glomerular Filtration Rate; Glomerulonephritis; Hypertension; Kidney Glomerulus; Leukocyte Count; Neutrophils; Pregnancy; Pregnancy Complications; Proteinuria; Rats; Rats, Wistar; Serum Albumin