apyrase and Hepatitis-C--Chronic

apyrase has been researched along with Hepatitis-C--Chronic* in 2 studies

Other Studies

2 other study(ies) available for apyrase and Hepatitis-C--Chronic

Article	Year
Different core-specific T cell subsets are expanded in chronic hepatitis C with advanced liver disease. Cytokine, 2019, Volume: 124 Chronic hepatitis C (CHC) is frequently related to liver fibrosis, and several studies have suggested that the immunological activity of HCV antigens contributes to hepatic damage. In the present study, among structural and non-structural HCV antigens, elevatedIL-1β, IL-6, IL-17 levels were secreted by PBMC cultures obtained from CHC patients following stimulation with core antigen. Moreover, the percentage of core-specific IL-6 Topics: Adult; Aged; Apyrase; CD28 Antigens; CD4-Positive T-Lymphocytes; CD57 Antigens; CD8-Positive T-Lymphocytes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interleukin-17; Interleukin-6; Leukocytes, Mononuclear; Liver; Liver Cirrhosis; Male; Middle Aged; T-Lymphocyte Subsets; Th17 Cells	2019
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS pathogens, 2015, Volume: 11, Issue:10 Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is enzymatically active, co-expressed with PD-1, marks cells with a transcriptional signature of T cell exhaustion and correlates with viral load in HIV and HCV. In the mouse model of chronic Lymphocytic Choriomeningitis Virus infection, virus-specific CD8+ T cells contain a population of CD39high CD8+ T cells that is absent in functional memory cells elicited by acute infection. This CD39high CD8+ T cell population is enriched for cells with the phenotypic and functional profile of terminal exhaustion. These findings provide a new marker of T cell exhaustion, and implicate the purinergic pathway in the regulation of T cell exhaustion. Topics: Animals; Antigens, CD; Apyrase; Arenaviridae Infections; Biomarkers; CD8-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Flow Cytometry; Hepatitis C, Chronic; HIV Infections; Humans; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; RNA Virus Infections; T-Lymphocyte Subsets	2015

Article

Year

Different core-specific T cell subsets are expanded in chronic hepatitis C with advanced liver disease.

Cytokine, 2019, Volume: 124

Chronic hepatitis C (CHC) is frequently related to liver fibrosis, and several studies have suggested that the immunological activity of HCV antigens contributes to hepatic damage. In the present study, among structural and non-structural HCV antigens, elevatedIL-1β, IL-6, IL-17 levels were secreted by PBMC cultures obtained from CHC patients following stimulation with core antigen. Moreover, the percentage of core-specific IL-6

Topics: Adult; Aged; Apyrase; CD28 Antigens; CD4-Positive T-Lymphocytes; CD57 Antigens; CD8-Positive T-Lymphocytes; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interleukin-17; Interleukin-6; Leukocytes, Mononuclear; Liver; Liver Cirrhosis; Male; Middle Aged; T-Lymphocyte Subsets; Th17 Cells

2019

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

PLoS pathogens, 2015, Volume: 11, Issue:10

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is enzymatically active, co-expressed with PD-1, marks cells with a transcriptional signature of T cell exhaustion and correlates with viral load in HIV and HCV. In the mouse model of chronic Lymphocytic Choriomeningitis Virus infection, virus-specific CD8+ T cells contain a population of CD39high CD8+ T cells that is absent in functional memory cells elicited by acute infection. This CD39high CD8+ T cell population is enriched for cells with the phenotypic and functional profile of terminal exhaustion. These findings provide a new marker of T cell exhaustion, and implicate the purinergic pathway in the regulation of T cell exhaustion.

Topics: Animals; Antigens, CD; Apyrase; Arenaviridae Infections; Biomarkers; CD8-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Flow Cytometry; Hepatitis C, Chronic; HIV Infections; Humans; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; RNA Virus Infections; T-Lymphocyte Subsets

2015