apyrase and Hepatitis-A

CD4. We analyzed blood samples collected from 63 patients with AHA at the time of hospitalization (and some at later time points) and 19 healthy donors in South Korea. Liver tissues were collected from patients with fulminant AHA during liver transplantation. Peripheral blood mononuclear cells were isolated from whole blood and lymphocytes were isolated from liver tissues and analyzed by flow cytometry. Cytokine production from Treg cells (CD4. A higher proportion of CD4. Treg cells from patients with AHA have altered functions compared with Treg cells from healthy individuals. Treg cells from patients with AHA produce higher levels of TNF, gain features of T-helper 17 cells, and have reduced suppressive activity. The presence of these cells is associated with severe liver injury in patients with AHA.

Topics: Acute Disease; Antigens, CD; Apyrase; Case-Control Studies; Cells, Cultured; DNA Methylation; Epigenesis, Genetic; Forkhead Transcription Factors; Hepatitis A; Hepatitis A virus; Host-Pathogen Interactions; Humans; Interleukin-2 Receptor alpha Subunit; Liver; Nuclear Receptor Subfamily 1, Group F, Member 3; Phenotype; Severity of Illness Index; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Time Factors; Tumor Necrosis Factor-alpha