apyrase and Cystadenocarcinoma--Serous

Ovarian cancer is the most lethal gynecological malignancy, with serous histotype as the most prevalent epithelial ovarian cancer (EOC). Peritoneal ascites is a frequent comorbidity in advanced EOC. EOC-associated ascites provide a reliable sampling source for studying lymphocytes directly from tumor environment. Herein, we carried out flow cytometry-based analysis to readdress issues on NK and T lymphocyte subsets in women with advanced EOC, additionally evaluating phenotypic modulation of their intracellular pathways involved in interleukin (IL)-2 and IL-15 signaling. Results depicted ascites as an inflammatory and immunosuppressive environment, presenting significantly (

Topics: Adult; Aged; Aged, 80 and over; Apyrase; Ascites; CD56 Antigen; Cystadenocarcinoma, Serous; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Interleukin-10; Interleukin-15; Interleukin-2; Interleukin-6; K562 Cells; Killer Cells, Natural; Middle Aged; Neoplasm Grading; Neoplasm Staging; Ovarian Neoplasms; Programmed Cell Death 1 Receptor; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Tumor Microenvironment