apyrase and Carcinoma--Pancreatic-Ductal

The purinergic signaling has an important role in regulating pancreatic exocrine secretion. The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic ductal adenocarcinoma (PDAC). Here, we explore how the network of purinergic and adenosine receptors, as well as ecto-nucleotidases regulate normal pancreatic cells and various cells within the pancreatic tumor microenvironment. In particular, we focus on the P2X7 receptor, P2Y

Topics: 5'-Nucleotidase; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Apyrase; Carcinoma, Pancreatic Ductal; Clinical Trials as Topic; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Immunotherapy; Pancreas; Pancreatic Neoplasms; Pancreatic Stellate Cells; Receptors, Adenosine A2; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y12; Receptors, Purinergic P2Y2; Signal Transduction; Tumor Microenvironment