aprotinin and Corneal-Injuries

The study of the influence of hordox, in treatment of experimental alkaline burn of the cornea, on the activity of trypsin-like proteases, elastases, callicreine, beta-N-acetylglucosaminidase and beta-glucuronidase in a tear fluid has shown that activity of these enzymes in a tear after burn remarkably increases, especially within first 24 hours and at the end of the second week after burn. In treatment by hordox, the activity of all enzymes in the tear, except elastase, reduces as compared with untreated animals, that speaks about antiinflammatory action of the preparation. On the basis of the data obtained it is suggested that investigation of hydrolytic enzymes in a tear can serve as a criterion for aimed correction of proteolysis in inflammatory processes in the cornea.

Topics: Animals; Aprotinin; Burns, Chemical; Cornea; Corneal Injuries; Drug Evaluation, Preclinical; Endopeptidases; Eye Burns; Glycoside Hydrolases; Rabbits; Sodium Hydroxide; Tears; Time Factors; Trypsin Inhibitors