aprotinin and Cellulitis

High clotting activity (CA) of monocytes, low level of macrophage CA, and increase of proteolytic activity (PA) of neutrophils in the inflammatory focus predominate in patients with deep phlegmons of the neck at the peak of inflammatory process. Blood monocytes retain their anticlotting potential and macrophages possess CA during resolution of the inflammatory process. The neutrophil PA in the blood and lavage fluid was lower during the resolution phase in comparison with the peak of inflammation. Differentiated correction of phagocyte PA and LA in the inflammatory focus, predicted by laboratory findings, reduced the incidence of mediastinitis and improved the disease outcomes.

Topics: Adolescent; Adult; Aged; Aprotinin; Blood Coagulation; Cellulitis; Female; Humans; Hydrolysis; Male; Middle Aged; Neck; Partial Thromboplastin Time; Peptide Hydrolases; Phagocytes; Plasminogen Activators; Streptokinase; Trypsin Inhibitors