aprindine has been researched along with Ventricular Fibrillation in 16 studies
Aprindine: A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of aprindine, verapamil and nifedipine on electrical stimulation threshold (EST) and ventricular fibrillation threshold (VFT) was studied in isolated rabbit hearts." | 7.67 | Effect of aprindine, verapamil and nifedipine on ventricular fibrillation threshold in isolated rabbit hearts. ( Almotrefi, AA, 1985) |
| "Twenty-three patients with recurrent ventricular tachycardia or ventricular fibrillation, or both, were treated with aprindine, a new antiarrhythmic agent." | 7.65 | Treatment of recurrent ventricular tachycardia and fibrillation with aprindine. ( Fasola, AF; Noble, RJ; Zipes, DP, 1977) |
| "A study was designed to investigate whether long-term use of aprindine can prevent sudden death from primary ventricular fibrillation." | 5.04 | Design of a study to evaluate drug therapy of serious ventricular rhythm disturbances after an acute myocardial infarction. ( Bogaert, M; Glaser, B; Hagemeijer, F; van Durme, JP, 1977) |
| "Sixty-four patients with a history of ventricular tachycardia and ventricular fibrillation refractory to conventional therapy received aprindine to abolish recurrent episodes of symptomatic ventricular tachycardia." | 3.67 | The utility of aprindine blood levels in the management of ventricular arrhythmias. ( Kallman, CH; Reid, PR; Vlay, SC, 1985) |
| "The effectiveness of three new antiarrhythmic drugs, aprindine, mexiletine and tocainide in elevating ventricular fibrillation threshold measured in the Langendorff-perfused rabbit heart and in protecting against ouabain-induced arrhythmias in the Langendorff-perfused guinea-pig heart has been compared with that of lignocaine." | 3.66 | The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs. ( Almotrefi, AA; Baker, JB, 1980) |
| "Twenty-three patients with recurrent ventricular tachycardia or ventricular fibrillation, or both, were treated with aprindine, a new antiarrhythmic agent." | 3.65 | Treatment of recurrent ventricular tachycardia and fibrillation with aprindine. ( Fasola, AF; Noble, RJ; Zipes, DP, 1977) |
| "The effect of intravenously administered aprindine (AC1802) as a prophylactic agent against ventricular arrhythmias was studied in pigs." | 3.65 | Cardiovascular and antiarrhythmic effects of aprindine (AC1802) during partial occlusion of a coronary artery in the pig. ( Hugenholtz, PG; Remme, WJ; Verdouw, PD, 1977) |
| "The influence of the excitability threshold on the ventricular fibrillation threshold was studied in dogs during myocardial ischemia and potassium and aprindine infusion." | 3.65 | Influence of excitability on the ventricular fibrillation threshold in dogs. ( Elharrar, V; Gaum, WE; Walker, PD; Zipes, DP, 1977) |
| "The effectiveness of aprindine, N-[3-(diethyl amino)propyl]-N-phenyl-2-indanamine, was examined against experimentally induced arrhythmias." | 3.65 | Antiarrhythmic and antifibrillatory properties of aprindine. ( Kroll, DA; Lucchesi, BR, 1975) |
| "The most important arrhythmia is ventricular tachycardia which degenerates to ventricular fibrillation." | 2.43 | [Strategy for cardiac arrhythmias in acute coronary syndrome]. ( Sugi, K, 2006) |
| "Aprindine is a very effective antiarrhythmic agent with a narrow therapeutic-toxic ratio." | 2.36 | Studies with aprindine. ( Elharrar, V; Gilmour, RF; Heger, JJ; Prystowsky, EN; Zipes, DP, 1980) |
| "Only aprindine was 100% successful at doses used in man." | 1.26 | Suppression of ouabain-induced ventricular rhythms with aprindine HCl. A comparison with other antiarrhythmic agents. ( Foster, PR; King, RM; Nicoll, AB; Zipes, DP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (93.75) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugi, K | 1 |
| Almotrefi, AA | 2 |
| Baker, JB | 1 |
| Zipes, DP | 4 |
| Elharrar, V | 2 |
| Gilmour, RF | 1 |
| Heger, JJ | 1 |
| Prystowsky, EN | 1 |
| Lubsen, J | 1 |
| Lüderitz, B | 1 |
| Manz, M | 1 |
| Steinbeck, G | 1 |
| Fasola, AF | 1 |
| Noble, RJ | 1 |
| Borger, HH | 1 |
| Vainsel, H | 1 |
| Dodion, L | 1 |
| Bernard, R | 1 |
| Denolin, H | 1 |
| Hagemeijer, F | 1 |
| Glaser, B | 1 |
| van Durme, JP | 1 |
| Bogaert, M | 1 |
| Koch-Weser, J | 1 |
| Verdouw, PD | 1 |
| Remme, WJ | 1 |
| Hugenholtz, PG | 1 |
| Gaum, WE | 1 |
| Walker, PD | 1 |
| Kroll, DA | 1 |
| Lucchesi, BR | 1 |
| Foster, PR | 1 |
| King, RM | 1 |
| Nicoll, AB | 1 |
| Vlay, SC | 1 |
| Kallman, CH | 1 |
| Reid, PR | 1 |
5 reviews available for aprindine and Ventricular Fibrillation
| Article | Year |
|---|---|
[Strategy for cardiac arrhythmias in acute coronary syndrome].
Topics: Amiodarone; Angina, Unstable; Anti-Asthmatic Agents; Aprindine; Atrial Fibrillation; Bepridil; Elect | 2006 |
Studies with aprindine.
Topics: Agranulocytosis; Animals; Aprindine; Arrhythmias, Cardiac; Cholestasis; Dogs; Electrophysiology; Hum | 1980 |
[Significance and therapy of extrasystole].
Topics: Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiac Output; Heart Ventricles; Hum | 1977 |
[Experimental models for the pharmacologic study of anti-arrhythmia drugs].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Aprindine; Coronary Vessels; Dogs; Drug Evaluation, Prec | 1977 |
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, | 1978 |
2 trials available for aprindine and Ventricular Fibrillation
| Article | Year |
|---|---|
Design of a study to evaluate drug therapy of serious ventricular rhythm disturbances after an acute myocardial infarction.
Topics: Aprindine; Clinical Trials as Topic; Computers; Death, Sudden; Follow-Up Studies; Humans; Indenes; I | 1977 |
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, | 1978 |
10 other studies available for aprindine and Ventricular Fibrillation
| Article | Year |
|---|---|
The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Dose-Response Relationship, Drug; Female; Guin | 1980 |
Secondary preventive trials with antiarrhythmic agents: are we asking the right question?
Topics: Anti-Arrhythmia Agents; Aprindine; Clinical Trials as Topic; Death, Sudden; Humans; Ventricular Fibr | 1984 |
[Ventricular heart-rhythm disorders - sudden cardiac death: results of long-term drug therapy].
Topics: Adult; Aged; Aprindine; Arrhythmias, Cardiac; Coronary Disease; Female; Germany, West; Humans; Inden | 1983 |
Treatment of recurrent ventricular tachycardia and fibrillation with aprindine.
Topics: Administration, Oral; Adult; Aged; Aprindine; Cardiac Complexes, Premature; Drug Administration Sche | 1977 |
Cardiovascular and antiarrhythmic effects of aprindine (AC1802) during partial occlusion of a coronary artery in the pig.
Topics: Animals; Aprindine; Arrhythmias, Cardiac; Carbon Dioxide; Coronary Disease; Indenes; Swine; Ventricu | 1977 |
Influence of excitability on the ventricular fibrillation threshold in dogs.
Topics: Animals; Aprindine; Cardiac Pacing, Artificial; Coronary Disease; Dogs; Female; Heart Ventricles; Ma | 1977 |
Antiarrhythmic and antifibrillatory properties of aprindine.
Topics: Animals; Aprindine; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Electrocardiography; Female; Inden | 1975 |
Suppression of ouabain-induced ventricular rhythms with aprindine HCl. A comparison with other antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Dogs; Indenes; Ouabain; Ventricular Fibrillation; Verapa | 1976 |
The utility of aprindine blood levels in the management of ventricular arrhythmias.
Topics: Aprindine; Dose-Response Relationship, Drug; Female; Humans; Indenes; Male; Middle Aged; Recurrence; | 1985 |
Effect of aprindine, verapamil and nifedipine on ventricular fibrillation threshold in isolated rabbit hearts.
Topics: Animals; Aprindine; Calcium Channel Blockers; Electric Stimulation; Female; Heart Rate; In Vitro Tec | 1985 |