aprepitant has been researched along with Nephritis* in 1 studies
1 other study(ies) available for aprepitant and Nephritis
Article | Year |
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Neurogenic tachykinin mechanisms in experimental nephritis of rats.
We demonstrated earlier that renal afferent pathways combine very likely "classical" neural signal transduction to the central nervous system and a substance P (SP)-dependent mechanism to control sympathetic activity. SP content of afferent sensory neurons is known to mediate neurogenic inflammation upon release. We tested the hypothesis that alterations in SP-dependent mechanisms of renal innervation contribute to experimental nephritis. Nephritis was induced by OX-7 antibodies in rats, 6 days later instrumented for recording of blood pressure (BP), heart rate (HR), drug administration, and intrarenal administration (IRA) of the TRPV1 agonist capsaicin to stimulate afferent renal nerve pathways containing SP and electrodes for renal sympathetic nerve activity (RSNA). The presence of the SP receptor NK-1 on renal immune cells was assessed by FACS. IRA capsaicin decreased RSNA from 62.4 ± 5.1 to 21.6 ± 1.5 mV s (*p < 0.05) in controls, a response impaired in nephritis. Suppressed RSNA transiently but completely recovered after systemic administration of a neurokinin 1 (NK1-R) blocker. NK-1 receptors occurred mainly on CD11 Topics: Animals; Aprepitant; Capsaicin; Chemokines; Dendritic Cells; Kidney; Macrophages; Male; Nephritis; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sympathetic Nervous System; Tachykinins; TRPV Cation Channels | 2020 |