aprepitant and Hypoglycemia

Aldosterone, produced by the adrenals and under the control of plasma angiotensin and potassium levels, regulates hydromineral homeostasis and blood pressure. Here we report that the neuropeptide substance P (SP) released by intraadrenal nerve fibres, stimulates aldosterone secretion via binding to neurokinin type 1 receptors (NK1R) expressed by aldosterone-producing adrenocortical cells. The action of SP is mediated by the extracellular signal-regulated kinase pathway and involves upregulation of steroidogenic enzymes. We also conducted a prospective proof-of-concept, double blind, placebo-controlled clinical trial aimed to investigate the impact of the NK1R antagonist aprepitant on aldosterone secretion in healthy male volunteers (EudraCT: 2008-003367-40, ClinicalTrial.gov: NCT00977223). Participants received during two 7-day treatment periods aprepitant (125 mg on the 1

Topics: Adolescent; Adrenal Cortex; Adrenal Glands; Adult; Aldosterone; Aprepitant; Cells, Cultured; Humans; Hypoglycemia; Male; Metoclopramide; Mineralocorticoids; Neurokinin-1 Receptor Antagonists; Placebos; Proof of Concept Study; Prospective Studies; Receptors, Neurokinin-1; Substance P; Transaminases; Young Adult