aprepitant and Gastroesophageal-Reflux

The present study was undertaken to elucidate the effect of pantoprazole and aprepitant on experimental esophagitis in albino rats. Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. Animals were sacrificed after 8 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index, and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with pantoprazole and aprepitant significantly inhibited the gastric secretion, total acidity, and esophagitis index. The treatment also helped to restore the altered levels oxidative stress parameters to normal.

Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aprepitant; Catalase; Disease Models, Animal; Drug Therapy, Combination; Gastroesophageal Reflux; Glutathione; Morpholines; Neurokinin-1 Receptor Antagonists; Pantoprazole; Proton Pump Inhibitors; Rats; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances