apratastat and Arthritis

apratastat has been researched along with Arthritis* in 1 studies

Other Studies

1 other study(ies) available for apratastat and Arthritis

Article	Year
Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6 A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1' groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TNF-alpha production and a collagen-induced arthritis model, was selected as a clinical candidate for the treatment of RA. Topics: Acetylene; ADAM Proteins; ADAM17 Protein; Administration, Oral; Alkynes; Animals; Arthritis; Caco-2 Cells; Collagen; Crystallography, X-Ray; Disease Models, Animal; Dogs; Enzyme Inhibitors; Haplorhini; Humans; Hydroxamic Acids; Lipopolysaccharides; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Mice; Molecular Structure; Morpholines; Propanols; Rats; Structure-Activity Relationship; Sulfonamides; Tumor Necrosis Factor-alpha	2006

Article

Year

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.

Bioorganic & medicinal chemistry letters, 2006, Mar-15, Volume: 16, Issue:6

A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1' groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TNF-alpha production and a collagen-induced arthritis model, was selected as a clinical candidate for the treatment of RA.

Topics: Acetylene; ADAM Proteins; ADAM17 Protein; Administration, Oral; Alkynes; Animals; Arthritis; Caco-2 Cells; Collagen; Crystallography, X-Ray; Disease Models, Animal; Dogs; Enzyme Inhibitors; Haplorhini; Humans; Hydroxamic Acids; Lipopolysaccharides; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Mice; Molecular Structure; Morpholines; Propanols; Rats; Structure-Activity Relationship; Sulfonamides; Tumor Necrosis Factor-alpha

2006