apoptolidin and Neoplasms

apoptolidin has been researched along with Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for apoptolidin and Neoplasms

ArticleYear
Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.
    Nature chemical biology, 2022, Volume: 18, Issue:4

    Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains uncertain. We used photoaffinity analogs of the apoptolidins to identify the F

    Topics: Adenosine Triphosphate; Humans; Leukemia; Macrolides; Mitochondrial Proton-Translocating ATPases; Neoplasms

2022
Synthesis of the C(1)-C(11) polyene fragment of apoptolidin with a new sulfur dioxide-based organic chemistry.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2005, Aug-05, Volume: 11, Issue:16

    A new sulfur dioxide-based organic chemistry has been developed as a novel approach for the stereoselective synthesis of polyene fragments based on our one-pot, four-component synthesis of polyfunctional epsilon-alkanesulfonyl-gamma,delta-unsaturated ketones. The flexibility and efficiency of this methodology are illustrated by the preparation of (+)-methyl (2E,4E,6E,8R,9S)-9-{[(tert-butyl)dimethylsilyl]oxy}-2,4,6,8-tetramethyl-11-(triethylsilyl)undeca-2,4,6-trien-10-ynoate, a synthetic intermediate of Nicolaou and co-workers, that corresponds to the C(1)-C(11) fragment of apoptolidin, which was used by the authors in their total synthesis of this promising anticancer agent.

    Topics: Actinobacteria; Animals; Antineoplastic Agents; Apoptosis; Macrolides; Molecular Conformation; Molecular Structure; Neoplasms; Rats; Sulfur Dioxide

2005