apoptolidin has been researched along with Neoplasms* in 2 studies
2 other study(ies) available for apoptolidin and Neoplasms
Article | Year |
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Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains uncertain. We used photoaffinity analogs of the apoptolidins to identify the F Topics: Adenosine Triphosphate; Humans; Leukemia; Macrolides; Mitochondrial Proton-Translocating ATPases; Neoplasms | 2022 |
Synthesis of the C(1)-C(11) polyene fragment of apoptolidin with a new sulfur dioxide-based organic chemistry.
A new sulfur dioxide-based organic chemistry has been developed as a novel approach for the stereoselective synthesis of polyene fragments based on our one-pot, four-component synthesis of polyfunctional epsilon-alkanesulfonyl-gamma,delta-unsaturated ketones. The flexibility and efficiency of this methodology are illustrated by the preparation of (+)-methyl (2E,4E,6E,8R,9S)-9-{[(tert-butyl)dimethylsilyl]oxy}-2,4,6,8-tetramethyl-11-(triethylsilyl)undeca-2,4,6-trien-10-ynoate, a synthetic intermediate of Nicolaou and co-workers, that corresponds to the C(1)-C(11) fragment of apoptolidin, which was used by the authors in their total synthesis of this promising anticancer agent. Topics: Actinobacteria; Animals; Antineoplastic Agents; Apoptosis; Macrolides; Molecular Conformation; Molecular Structure; Neoplasms; Rats; Sulfur Dioxide | 2005 |