apomorphine has been researched along with Nerve Degeneration in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (26.87) | 18.7374 |
| 1990's | 19 (28.36) | 18.2507 |
| 2000's | 19 (28.36) | 29.6817 |
| 2010's | 11 (16.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Cheng, L; Gao, C; Liu, H; Ren, Z; Wang, Y; Wei, X; Wen, H; Zeng, S; Zhang, X | 1 |
| Choudhury, ME; Kubo, M; Miyanishi, K; Nomoto, M; Tanaka, J; Watanabe, M; Yano, H | 1 |
| He, Q; Li, R; Liang, T; Xu, L; Zheng, N | 1 |
| Brekk, OR; Kirik, D; Landeck, N; Papadopoulou-Daifoti, Z; Papasilekas, T; Pitychoutis, PM; Stefanis, L; Xilouri, M | 1 |
| Britto, LR; Café-Mendes, CC; Hernandes, MS; Lima, LS; Munhoz, CD; Santos, GD; Scavone, C | 1 |
| Britto, LR; Café-Mendes, CC; Hernandes, MS | 1 |
| Björklund, A; Carta, M; Devoto, P; Rogers, JT; Shin, E | 1 |
| Cheng, CY; Chiu, CH; Chou, TK; Huang, WS; Huang, YS; Li, IH; Liao, MH; Ma, KH; Shiue, CY; Weng, SJ; Wu, SC | 1 |
| Chen, C; Fan, Q; Huang, J; Pan, X; Wei, H | 1 |
| Bi, J; Gu, S; Huang, H; Wen, T; Yao, Y | 1 |
| Björklund, A; Draxler, P; Grealish, S; Mattsson, B | 1 |
| Bähr, M; Garrido, M; Kügler, S; Taschenberger, G; Tereshchenko, Y; Zhevtsova, Z | 1 |
| Aihara, N; Hida, H; Imamura, N; Ishida, K; Kanda, Y; Nishino, H; Yamada, K | 1 |
| Bartiromo, M; Bertolini, A; Ferrari, A; Genedani, S; Ottani, A; Renzo Botticelli, A; Saltini, S; Zaffe, D | 1 |
| Bonatto, F; da Silva, EG; Dal-Pizzol, F; Flores, DG; Henriques, JA; Moreira, JC; Picada, JN; Roesler, R | 1 |
| Andsberg, G; Arvidsson, A; Kirik, D; Kokaia, Z; Lindvall, O; Lundberg, C; Mandel, RJ | 1 |
| Ballok, DA; Earls, AM; Hoffman, SA; Krasnik, C; Sakic, B | 1 |
| Hashemi, L; Joghataie, MT; Negahdar, F; Roghani, M | 1 |
| Kääriäinen, T; Kulkarni, SK; Manáková, S; Männistö, PT; Singh, A; Taari, H | 1 |
| Billinton, A; Brown, M; Chapman, H; Quinn, LP; Stean, TO; Upton, N; Vidgeon-Hart, M; Virley, DJ | 1 |
| Aurelian, L; Golembewski, EK; Wales, SQ; Yarowsky, PJ | 1 |
| McLarnon, JG; Ryu, JK; Tran, KC | 1 |
| Amorosi, A; De Fazio, P; De Fazio, S; De Sarro, G; Donato, G; Perrotta, I; Russo, E | 1 |
| Sundén-Kuronen, B | 1 |
| Agnati, LF; Andersson, K; Fuxe, K; Hall, H; Köhler, C; Ogren, SO; Schwarcz, R | 1 |
| Agnati, LF; Altamimi, U; Andbjer, B; Finnman, UB; Fuxe, K; Goldstein, M; Janson, AM; Rosén, L; Ueki, A | 1 |
| Heim, C; Sontag, KH | 1 |
| Granata, R; Jenner, P; Laboyrie, PM; Marsden, CD; Quinn, NP; Wenning, GK | 1 |
| Kraus, PH | 1 |
| Brundin, P; Nakao, N | 1 |
| Brouillet, E; Guyot, MC; Hantraye, P; Mary, V; Palfi, S; Peschanski, M; Riche, D; Stutzmann, JM; Wahl, F | 1 |
| Cozzari, C; Faris, PL; Hartman, BK; Jansen, EM; Low, WC; Solberg, L; Underhill, S; Wilson, S | 1 |
| Goto, S; Okamura, A; Ushio, Y; Yamada, K; Yoshikawa, M | 1 |
| Björklund, A; Kirik, D; Rosenblad, C | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, J | 1 |
| Björklund, A; Devaux, B; Kirik, D; Moffat, B; Phillips, HS; Rosenblad, C | 1 |
| Pollack, AE; Strauss, JB | 1 |
| Arzberger, T; Heim, C; Herbinger, KH; Sontag, KH; Sontag, T; Weindl, A; Xiao, A | 1 |
| Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK | 1 |
| Grünblatt, E; Mandel, S; Youdim, MB | 1 |
| Allen, C; Meshul, CK | 1 |
| Aoi, M; Date, I; Ohmoto, T; Tomita, S | 2 |
| Freund, RK; Gerhardt, GA; Giardina, KE; Granholm, AC; Moorhead, JW; Palmer, MR; van Horne, CG | 1 |
| Aceves, J; Erlij, D; Floran, B; Galvan, A | 1 |
| Cicchetti, F; Hennen, J; Isacson, O; Moore, AE | 1 |
| Costa, E; Guidotti, A; Lucchelli, A | 1 |
| Hoffer, B; Ljungberg, T; Siggins, G; Ungerstedt, U | 1 |
| Finn, BW; Mendez, JS | 1 |
| Watanabe, H; Watanabe, K | 1 |
| Schultz, W; Ungerstedt, U | 1 |
| Ljungberg, T; Ungerstedt, U | 2 |
| Moore, KE; Thornburg, JE | 1 |
| Creese, I; Iversen, SD | 2 |
| Fukamauchi, F; Shibuya, H; Yoshikawa, T | 1 |
| Ben-Shachar, D; Pinhassi, B; Youdim, MB | 1 |
| Murer, MG; Pazo, JH; Riquelme, LA; Stern, J | 1 |
| Coyle, JT; Miyamoto, M | 1 |
| Szechtman, H; Ziegler, MG | 1 |
| Ungerstedt, U | 3 |
| Aghajanian, GK; Asher, IM | 1 |
| Ljungberg, T; Steg, G; Ungerstedt, U | 1 |
| Eichelman, B; Ng, LK; Thoa, NB | 1 |
1 review(s) available for apomorphine and Nerve Degeneration
| Article | Year |
|---|---|
Early diagnosis in Parkinson's disease--limitation of biochemical markers and instrumental methods.
Topics: Apomorphine; Biomarkers; Cell Death; Corpus Striatum; Diagnostic Imaging; Electrophysiology; Humans; Levodopa; Nerve Degeneration; Parkinson Disease; Substantia Nigra; Time Factors | 1996 |
66 other study(ies) available for apomorphine and Nerve Degeneration
| Article | Year |
|---|---|
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; Nerve Degeneration; Nod2 Signaling Adaptor Protein; Oxidopamine; Parkinson Disease, Secondary; Reactive Oxygen Species | 2018 |
Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model.
Topics: Animals; Apomorphine; Behavior Rating Scale; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Male; Motor Activity; Nerve Degeneration; Parkinson Disease; Rats, Wistar; Substantia Nigra | 2019 |
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Isoflavones; Male; Malondialdehyde; Microtubule-Associated Proteins; Motor Activity; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Oxidoreductases; Protein Deglycase DJ-1; Rats; Rats, Wistar; Substantia Nigra; Time Factors | 2013 |
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.
Topics: alpha-Synuclein; Amphetamine; Analysis of Variance; Animals; Apomorphine; Autophagy; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Dependovirus; Dopamine; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Hemagglutinins; Humans; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 2; Macrolides; Mice; Molecular Chaperones; Motor Activity; Nerve Degeneration; Neuroblastoma; Neurons; Rats; Transfection; Tyrosine 3-Monooxygenase | 2013 |
Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Minocycline; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nerve Degeneration; NF-kappa B; Oxidopamine; Parkinson Disease; Substantia Nigra; Tumor Necrosis Factor-alpha | 2013 |
NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice.
Topics: Animals; Apomorphine; CD11b Antigen; Dopaminergic Neurons; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Neostriatum; Nerve Degeneration; Oxidopamine; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benzylamines; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Motor Activity; Nerve Degeneration; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Stereotyped Behavior | 2014 |
PET Imaging of Serotonin Transporters With 4-[(18)F]-ADAM in a Parkinsonian Rat Model With Porcine Neural Xenografts.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Nerve Degeneration; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra; Swine; Transplantation, Heterologous | 2016 |
Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.
Topics: Animals; Apomorphine; Benserazide; Combined Modality Therapy; Drug Combinations; Glial Fibrillary Acidic Protein; Glutathione Peroxidase; Hyperbaric Oxygenation; Levodopa; Lipid Peroxidation; Male; Malondialdehyde; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase | 2015 |
Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Movement; Cells, Cultured; Disease Models, Animal; Dopamine; Genetic Therapy; Maze Learning; Medial Forebrain Bundle; Motor Activity; Nerve Degeneration; Neurogenesis; Neurons; Neurotrophin 3; Oxidopamine; Parkinsonian Disorders; Rats; Stem Cell Transplantation; Stem Cells; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Female; Mice; Nerve Degeneration; Neural Pathways; Neuropsychological Tests; Oxidopamine; Parkinson Disease; Substantia Nigra; Sympatholytics | 2010 |
Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Apomorphine; Catalytic Domain; Cell Survival; Cysteine; Disease Models, Animal; Dopamine; Dopamine Agonists; Female; Gene Expression Regulation; Gliosis; Glutathione; Glutathione Reductase; Green Fluorescent Proteins; Movement; Nerve Degeneration; Rats; Rats, Wistar; RNA, Small Interfering; Sensation Disorders; Stereotyped Behavior; Substantia Nigra; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2011 |
Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage.
Topics: Animals; Apomorphine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Dopamine Agonists; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Immunohistochemistry; In Situ Hybridization; Macrophages; Male; Membrane Proteins; Methamphetamine; Microglia; Mitogen-Activated Protein Kinases; Nerve Degeneration; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Effect of gamma-hydroxybutyrate in two rat models of focal cerebral damage.
Topics: Animals; Apomorphine; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Kainic Acid; Learning; Male; Memory Disorders; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Sodium Oxybate | 2003 |
Oxidative damage in brains of mice treated with apomorphine and its oxidized derivative.
Topics: Animals; Apomorphine; Brain; Catalase; Dopamine Agonists; Dose-Response Relationship, Drug; Free Radicals; Male; Mice; Nerve Degeneration; Neurons; Oxidative Stress; Quinones; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbiturates | 2003 |
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
Topics: Adenoviridae; Animals; Apomorphine; Cell Death; Cell Survival; Corpus Striatum; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Infarction, Middle Cerebral Artery; Lentivirus; Male; Movement Disorders; Nerve Degeneration; Nerve Growth Factors; Rats; Rats, Wistar; Stroke; Transduction, Genetic; Treatment Failure; Up-Regulation | 2003 |
Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice.
Topics: Age Factors; Animals; Apomorphine; Autoantibodies; Autoimmunity; Behavior, Animal; Cerebrospinal Fluid; Cyclophosphamide; Disease Models, Animal; Dopamine; Dopamine Agonists; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Male; Mesencephalon; Mice; Mice, Inbred MRL lpr; Nerve Degeneration; Neurons; Tumor Necrosis Factor-alpha | 2004 |
Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Caffeine; Cell Count; Central Nervous System Stimulants; Functional Laterality; Male; Nerve Degeneration; Neurons; Parkinson Disease, Secondary; Rats; Rats, Wistar; Rotation; Stereotyped Behavior; Substantia Nigra | 2004 |
Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.
Topics: Animals; Apomorphine; Behavior, Animal; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Immunophilins; Male; Motor Activity; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Random Allocation; Rats; Rats, Wistar; Tacrolimus | 2005 |
Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Apomorphine; Automation; Behavior, Animal; Benzazepines; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrochemistry; Haloperidol; Hyperkinesis; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Nerve Degeneration; Psychology, Experimental; Reproducibility of Results; Substantia Nigra | 2006 |
The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
Topics: Animals; Apomorphine; Apoptosis; Behavior, Animal; Chlorocebus aethiops; Coloring Agents; Dopamine Agonists; Electron Transport Complex IV; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Indicators and Reagents; Injections; Male; Mice; Mitogen-Activated Protein Kinase Kinases; N-Methylaspartate; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenothiazines; Protein Serine-Threonine Kinases; Ribonucleotide Reductases; Vero Cells | 2007 |
Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo.
Topics: Animals; Apomorphine; Blood-Brain Barrier; Cell Survival; Gliosis; Immunohistochemistry; Inflammation; Male; Microglia; Neostriatum; Nerve Degeneration; Neurons; Neutrophils; Oxidative Stress; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Superoxides | 2007 |
Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Gerbillinae; Hippocampus; Humans; Microscopy, Electron, Scanning; Nerve Degeneration; Neurons; Schizophrenia | 2007 |
Experimental dyskinesias of the jaw: central and oral induction of the periodontal-masseteric reflex in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Bruxism; Hypnotics and Sedatives; Male; Masticatory Muscles; Movement Disorders; Muscle Relaxants, Central; Muscle Tonus; Nerve Degeneration; Periodontium; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reflex; Sensation; Serotonin; Substance P | 1984 |
Effects of chronic treatment with l-sulpiride and haloperidol on central monoaminergic mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Behavior, Animal; Biogenic Amines; Brain; Haloperidol; Hydroxydopamines; Ibotenic Acid; Male; Nerve Degeneration; Rats; Sulpiride; Time Factors | 1980 |
The vigilance-promoting drug modafinil counteracts the reduction of tyrosine hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Arousal; Benzhydryl Compounds; Biogenic Monoamines; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Agents; Male; Modafinil; Nerve Degeneration; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 1993 |
Memantine prevents progressive functional neurodegeneration in rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memantine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Fetal Tissue Transplantation; Graft Survival; Immunohistochemistry; Male; Mesencephalon; Nerve Degeneration; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Substantia Nigra; Transplantation, Homologous | 1996 |
Effects of alpha-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid.
Topics: Amphetamine; Animals; Apomorphine; Cell Survival; Cyclic N-Oxides; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Female; Functional Laterality; Immunohistochemistry; Motor Neurons; Movement; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Nitro Compounds; Nitrogen Oxides; Phosphoproteins; Propionates; Quinolinic Acids; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1997 |
Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration.
Topics: Acetylcholinesterase; Animals; Antiparkinson Agents; Apomorphine; Caudate Nucleus; Corpus Striatum; Movement Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Papio; Parkinson Disease, Secondary; Propionates; Putamen; Riluzole; Thiazoles | 1997 |
Transplantation of fetal neocortex ameliorates sensorimotor and locomotor deficits following neonatal ischemic-hypoxic brain injury in rats.
Topics: Animals; Animals, Newborn; Apomorphine; Brain Damage, Chronic; Brain Ischemia; Brain Tissue Transplantation; Fetal Hypoxia; Fetal Tissue Transplantation; Hypoxia, Brain; Movement Disorders; Neocortex; Nerve Degeneration; Psychomotor Performance; Rats; Rats, Wistar; Sensation Disorders; Stereotyped Behavior | 1997 |
GABA receptor agonist promotes reformation of the striatonigral pathway by transplant derived from fetal striatal primordia in the lesioned striatum.
Topics: Animals; Apomorphine; Brain Damage, Chronic; Brain Ischemia; Brain Tissue Transplantation; Cell Count; Chemotherapy, Adjuvant; Combined Modality Therapy; Corpus Striatum; Fetal Tissue Transplantation; GABA Agonists; Infusion Pumps, Implantable; Male; Muscimol; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, GABA; Stereotyped Behavior; Substantia Nigra | 1997 |
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Forelimb; Microinjections; Motor Activity; Nerve Degeneration; Neurons; Oxidopamine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle.
Topics: Amphetamine; Animals; Antibodies; Apomorphine; Atrophy; Body Weight; Cerebral Ventricles; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Agonists; ELAV Proteins; Female; Glial Cell Line-Derived Neurotrophic Factor; Hydrogen-Ion Concentration; Injections, Intraventricular; Nerve Degeneration; Nerve Growth Factors; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurturin; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 1999 |
Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Corpus Striatum; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; Nerve Degeneration; Oxidopamine; Piperazines; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Rotation; Sympatholytics; Time Factors | 1999 |
Progressive degeneration of dopamine system functions after transient cerebral oligemia in rats.
Topics: Animals; Apomorphine; Carotid Arteries; Dopamine; Dopamine Agonists; Ischemic Attack, Transient; Male; Motor Activity; Nerve Degeneration; Rats; Receptors, Dopamine D1; RNA, Messenger | 1999 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Fetal Tissue Transplantation; Male; Mazindol; Nerve Degeneration; Neurons; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Substantia Nigra; Sympatholytics; Tritium | 2000 |
The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration. Prospects for neuroprotection in Parkinson's disease with iron chelators.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agents; Ferritins; Iron; Lipid Peroxidation; Mice; Nerve Degeneration; NF-kappa B; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Tyrosine 3-Monooxygenase | 1999 |
Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion.
Topics: Animals; Apomorphine; Denervation; Dopamine Agonists; Dopamine Antagonists; Glutamic Acid; Haloperidol; Immunohistochemistry; Male; Motor Cortex; Neostriatum; Nerve Degeneration; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages.
Topics: Animals; Apomorphine; Axons; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Movement; Neostriatum; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase; Weight Loss | 2000 |
Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system.
Topics: Animals; Antibodies; Apomorphine; Behavior, Animal; Cell Count; Corpus Striatum; Dopamine; Dopamine Agonists; Female; Glial Cell Line-Derived Neurotrophic Factor; Image Processing, Computer-Assisted; Microinjections; Nerve Degeneration; Nerve Fibers; Nerve Growth Factors; Nerve Tissue Proteins; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Recovery of Function; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Male; Nerve Degeneration; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Inbred F344; Recovery of Function; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2001 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Motor Activity; Nerve Degeneration; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Recovery of Function; Sulpiride; Sympatholytics | 2001 |
Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Extremities; Female; Head; Motor Activity; Nerve Degeneration; Neurons; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Tegmentum Mesencephali | 2001 |
Stratial content of Ca2+-dependent regulator protein and dopaminergic receptor function.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Apomorphine; Calcium; Cerebellum; Corpus Striatum; Denervation; Enzyme Activation; Frontal Lobe; Haloperidol; Male; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Nucleus Accumbens; Rats; Receptors, Dopamine; Tyrosine 3-Monooxygenase | 1978 |
Dopaminergic supersensitivity in the striatum.
Topics: Amphetamine; Apomorphine; Caudate Nucleus; Corpus Striatum; Cyclic AMP; Dopamine; Hydroxydopamines; Motor Activity; Nerve Degeneration; Neural Pathways; Neurons; Receptors, Drug; Synaptic Transmission | 1975 |
Use of 6-hydroxydopamine to create lesions in catecholamine neurons in rats.
Topics: Animals; Apomorphine; Brain; Brain Chemistry; Carbidopa; Dopamine; Dose-Response Relationship, Drug; Hydroxydopamines; Levodopa; Male; Movement; Nerve Degeneration; Neurons; Neurotransmitter Agents; Oxotremorine; Parkinson Disease, Secondary; Rats; Rotation; Stereotaxic Techniques; Substantia Nigra; Synaptic Transmission; Time Factors | 1975 |
Enhancement of apomorphine-induced rotational behaviour in rats following the combination of 6-hydroxydopamine and electrolytic lesions in the substantia nigra.
Topics: Amines; Amphetamines; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Electrolysis; Functional Laterality; Histocytochemistry; Hydroxydopamines; Nerve Degeneration; Rats; Rotation; Substantia Nigra | 1979 |
Striatal cell supersensitivity to apomorphine in dopamine-lesioned rats correlated to behaviour.
Topics: Animals; Apomorphine; Behavior; Corpus Striatum; Dopamine; Humans; Hydroxydopamines; Male; Nerve Degeneration; Neurons; Rats; Stereotyped Behavior | 1978 |
Reinstatement of eating by dopamine agonists in aphagic dopamine denervated rats.
Topics: Animals; Apomorphine; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Humans; Hydroxydopamines; Hypothalamus; Levodopa; Male; Motor Activity; Nerve Degeneration; Parkinson Disease; Piperazines; Rats; Receptors, Dopamine; Stereotyped Behavior; Stimulation, Chemical | 1976 |
Drug-induced dopaminergic supersensitivity.
Topics: Animals; Apomorphine; Depression, Chemical; Dopamine; Drug Interactions; Haloperidol; Hydroxydopamines; Methyltyrosines; Mice; Models, Biological; Motor Activity; Nerve Degeneration; Pimozide; Piribedil; Receptors, Drug; Stimulation, Chemical; Time Factors | 1975 |
Behavioral correlates of dopaminergic supersensitivity.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxydopamines; Hypothalamus; Levodopa; Motor Activity; Nerve Degeneration; Rats; Receptors, Drug; Stereotyped Behavior; Substantia Nigra; Tranylcypromine; Tyrosine | 1975 |
Behavioural sequelae of dopaminergic degeneration: postsynaptic supersensitivity?
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Nerve Degeneration; Peripheral Nerves; Rats; Substantia Nigra; Synapses | 1975 |
Pre-synaptic dopaminergic control mechanisms for CCK-8 like immunoreactivity in the rat medial frontal cortex.
Topics: Animals; Apomorphine; Behavior, Animal; Cholecystokinin; Dopamine; Dopamine Agents; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine | 1992 |
Prevention of neuroleptic-induced dopamine D2 receptor supersensitivity by chronic iron salt treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Chlorpromazine; Chromatography, High Pressure Liquid; Dopamine; Ferrous Compounds; Free Radicals; Hemoglobins; Homovanillic Acid; In Vitro Techniques; Iron; Liver; Male; Nerve Degeneration; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1991 |
Role of the mesopontine area in the circling behavior induced by apomorphine in rats bearing unilateral lesion of the entopeduncular nucleus.
Topics: Animals; Apomorphine; Brain Mapping; Corpus Striatum; Dominance, Cerebral; Globus Pallidus; Kainic Acid; Male; Motor Activity; Nerve Degeneration; Neural Pathways; Pons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Superior Colliculi; Thalamic Nuclei | 1991 |
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins.
Topics: Animals; Apomorphine; Benzoquinones; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Histocytochemistry; Kainic Acid; Kinetics; Male; Motor Activity; NADPH Dehydrogenase; Nerve Degeneration; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quinones; Quisqualic Acid; Rats; Rats, Inbred Strains; Ubiquinone | 1990 |
Relation between motor asymmetry and direction of rotational behaviour under amphetamine and apomorphine in rats with unilateral degeneration of the nigrostriatal dopamine system.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Dominance, Cerebral; Dopamine; Dose-Response Relationship, Drug; Hindlimb; Locomotion; Male; Motor Activity; Nerve Degeneration; Neural Pathways; Orientation; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1990 |
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
Topics: Amphetamine; Animals; Apomorphine; Brain; Butyrophenones; Dopamine; Electrocoagulation; Haloperidol; Histological Techniques; Male; Mixed Function Oxygenases; Movement Disorders; Nerve Degeneration; Nialamide; Norepinephrine; Posture; Rats; Reserpine; Rotation; Stereotaxic Techniques; Substantia Nigra; Synaptic Transmission; Time Factors | 1971 |
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
Topics: Animals; Apomorphine; Brain Chemistry; Brain Injuries; Carboxy-Lyases; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Electrocoagulation; Female; Histological Techniques; Male; Nerve Degeneration; Rats; Receptors, Drug; Receptors, Neurotransmitter; Reserpine; Rotation; Stereotaxic Techniques; Substantia Nigra; Synapses; Synaptic Transmission | 1971 |
Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.
Topics: Animals; Apomorphine; Axons; Benzimidazoles; Body Weight; Brain; Brain Injuries; Brain Mapping; Catalepsy; Cerebral Ventricles; Dopamine; Feeding and Eating Disorders; Humans; Hypothalamus; Male; Mental Disorders; Microscopy, Fluorescence; Nerve Degeneration; Posture; Rats; Stereotaxic Techniques; Stimulation, Chemical; Substantia Nigra; Synaptic Transmission; Thirst | 1971 |
6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: effect on amphetamine-induced stereotyped behavior in rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior; Behavior, Animal; Brain Chemistry; Brain Mapping; Caudate Nucleus; Disease Models, Animal; Dopamine; Histocytochemistry; Humans; Hydroxydopamines; Limbic System; Male; Microscopy, Fluorescence; Nerve Degeneration; Neural Pathways; Olfactory Bulb; Psychoses, Substance-Induced; Rats; Stereotyped Behavior; Synaptic Transmission | 1974 |
Central dopamine neurons and sensory processing.
Topics: Animals; Apomorphine; Auditory Perception; Behavior, Animal; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Functional Laterality; Limbic System; Nerve Degeneration; Neurons; Orientation; Receptors, Drug; Reflex; Sensation; Smell; Touch; Visual Perception | 1974 |
Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Drinking Behavior; Electric Stimulation; Electromyography; Feeding and Eating Disorders; Feeding Behavior; Humans; Hydroxydopamines; Levodopa; Motor Neurons; Muscle Contraction; Nerve Degeneration; Neural Pathways; Parkinson Disease; Parkinson Disease, Secondary; Perceptual Disorders; Rats; Reflex, Stretch; Substantia Nigra | 1974 |
Shock-induced aggression: effects of 6-hydroxydopamine and other pharmacological agents.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Brain; Catecholamines; Desipramine; Dihydroxyphenylalanine; Disulfides; Dopamine; Electroshock; Humans; Male; Methyltyrosines; Nerve Degeneration; Nerve Endings; Norepinephrine; Rats | 1972 |