apomorphine has been researched along with Disease Models, Animal in 478 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 67 (14.02) | 18.7374 |
1990's | 63 (13.18) | 18.2507 |
2000's | 147 (30.75) | 29.6817 |
2010's | 180 (37.66) | 24.3611 |
2020's | 21 (4.39) | 2.80 |
Authors | Studies |
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Bhatia, P; Brioni, JD; Chang, R; Donnelly-Roberts, DL; El Kouhen, O; Hakeem, AA; Henry, R; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martino, B; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Patel, MV; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
Fan, F; Liu, S; Wang, Y; Zheng, Y; Zhou, J | 1 |
Mohajeri, D; Nourazar, MA; Sokouti, H | 1 |
Chan, P; Ding, H; Liu, Y; Ren, Z; Yang, N; Zhou, M | 1 |
Cañete, T; Corda, MG; Fernández-Teruel, A; Giorgi, O; Oliveras, I; Río-Álamos, C; Sampedro-Viana, D; Tobeña, A | 1 |
Bilal, B; Erbas, O; Erdogan, MA; Kirazlar, M; Yigitturk, G | 1 |
Alam, M; Elle, T; John, N; Krauss, JK; Schwabe, K; Voigt, C | 1 |
Tian, H; Xiao, W; Xue, B | 1 |
Abd-Elrahman, KS; Bureau, SC; Derksen, A; Dwyer, Z; Farmer, K; Ferguson, SSG; Fortin, T; Hayley, S; Prowse, NA; Rowe, EM; Rudyk, CA; Thompson, AM | 1 |
Botha, TL; Brand, SJ; de Brouwer, G; Finger-Baier, K; van Staden, C; Wolmarans, D | 1 |
Dravid, SM; Gakare, SG; Gawai, P; Sarode, L; Ugale, RR; Upadhyay, R | 1 |
da Costa, RO; de Araújo, DP; de Barros Viana, GS; de Lucena, JD; Gadelha-Filho, CVJ; Lima, FAV; Neves, KRT | 1 |
Balenovic, I; Blagaic, AB; Cilic, M; Drmic, D; Filipcic, I; Ilic, S; Kokot, A; Seiwerth, S; Sikiric, P; Strbe, S; Tvrdeic, A; Vukojevic, J; Zemba Cilic, A; Zemba, M; Zoricic, Z | 1 |
Fu, X; Liu, J; Lu, XJ; Sun, Y; Xia, CL; Zhan, Y; Zhang, Y; Zhao, L | 1 |
Galabov, AS; Stoyanova, A | 1 |
Ahmed, S; Haleem, DJ; Ikram, H | 1 |
Costa, G; Marongiu, J; Morelli, M; Serra, M; Simola, N | 1 |
Abuirmeileh, AN; Alzoubi, KH; Rababa'h, AM | 1 |
Deev, A; Nebogatikov, V; Sengpiel, F; Ustyugov, AA; Vorobyov, V | 1 |
Abuhamdah, SM; Abuirmeileh, AN; Alzoubi, KH; Ashraf, A | 1 |
Antipova, V; Hawlitschka, A; Holzmann, C; Witt, M; Wree, A | 1 |
Funamizu, Y; Mizukami, H; Nishijima, H; Tomiyama, M; Ueno, S; Ueno, T; Yagihashi, S | 1 |
Aldana, L; Berlanga, J; Garcia Del Barco, D; Perez-Saad, H; Subiros, N | 1 |
Nemas, M; Nyska, A; Ramot, Y; Rubinski, A; Schiffenbauer, YS; Shaltiel-Karyo, R; Tsarfati, Y; Weinstock, I; Yacoby-Zeevi, O; Zawoznik, E | 1 |
Alam, M; Grothe, C; Jin, X; Krauss, JK; Ratzka, A; Rumpel, R; Schwabe, K; Tschirner, SK; von Wrangel, C | 1 |
Iinuma, KM; Imamura, T; Kira, JI; Murai, H; Nakamura, N; Ohyagi, Y; Soejima, N; Yamasaki, R; Yanagihara, YT | 1 |
Pandy, V; Vijeepallam, K | 1 |
Adjei, S; Amoateng, P; Karikari, TK; Kukuia, KKE; Nyarko, AK; Osei-Safo, D | 1 |
Adjei, S; Amoateng, P; Bekoe, EO; Karikari, TK; Kombian, SB; Kukuia, KKE; Osei-Safo, D | 1 |
Jaehne, EJ; Lee, JJW; van den Buuse, M | 1 |
Aderibigbe, AO; Ajayi, AM; Ben-Azu, B; Iwalewa, EO; Omogbiya, IA | 1 |
Ai, Y; Andersen, AH; Evans, A; Forman, E; Gash, DM; Grondin, R; Hardy, PA; Yue, G; Yue, J; Zhang, R; Zhang, Z | 1 |
Chen, YH; Gou, Y; Li, HW; Li, Y; Lin, X; Tang, L; Wen, M; Zhang, Y; Zhou, B | 1 |
Açikalin, Ö; Bölükbaşi Hatip, F; Hatip-Al-Khatib, I; Kataoka, Y; Tan, R; Yamauchi, A | 1 |
Ando, K; Inoue, R; Kawai, K; Nishime, C; Nishinaka, E; Tsutsumi, H; Urano, K | 1 |
Christensen, KV; Christoffersen, CT; Clausen, D; Didriksen, M; Egebjerg, J; Fejgin, K; Kallunki, P; Larsen, PH; Lauridsen, JB; Mørk, A; Nielsen, J; Nielsen, V; Sotty, F; Werge, TM; Yavich, L | 1 |
Bozza, G; Busceti, CL; Fornai, F; Gaglione, A; Mastroiacovo, F; Nicoletti, F; Orzi, F; Ryskalin, L | 1 |
Babayan-Tazehkand, A; Haghdoost-Yazdi, H; Rastgoo, N; Sarbazi-Golezari, A; Sarookhani, MR | 1 |
Chen, G; Chen, J; Chen, Y; Dai, Y; Jiang, H; Yang, B; Yu, W; Zang, F; Zhu, L | 1 |
Bjarkam, CR; Christensen, AB; Ettrup, KS; Orlowski, D; Sørensen, JCH | 1 |
de Campos, PS; Hasegawa, K; Kawamura, LRSM; Kumei, Y; Zeredo, JL | 1 |
Liu, J; Wang, X; Wang, Y | 1 |
Du, CX; Liu, J; Sun, YN; Wang, HS; Wang, Y; Yao, L; Zhang, GJ; Zhang, L | 1 |
Babayan-Tazehkand, A; Dargahi, T; Haghdoost-Yazdi, H; Rastgoo, N; Sarbazi Golezari, A; Sarukhani, M | 1 |
Dohgu, S; Fukae, J; Kataoka, Y; Koga, M; Matsumoto, J; Nakashima, A; Takata, F; Tsuboi, Y; Yamauchi, A | 1 |
Chen, J; Huang, F; Li, Q; Qu, J; Wang, Q; Wu, Y; Yang, Y; Zhang, L; Zhou, X | 1 |
Chan, MH; Chang, PC; Chen, C; Chen, HH | 1 |
Anderson, KA; Bhupal, PK; Dunbar, GL; Hoolsema, KS; Lynn, JD; Rossignol, J; Sandstrom, MI; Shall, GP | 1 |
Du, CX; Guo, Y; Liu, J; Lv, SX; Zhang, J; Zhang, QJ | 1 |
Li, K; Li, Y; Na, S; Wu, J; Xie, X; Yang, J; Yang, Z; Yu, X; Yue, J | 1 |
Chen, L; Cheng, L; Gao, C; Liu, H; Ren, Z; Wang, Y; Wei, X; Wen, H; Zeng, S; Zhang, X | 1 |
Andrade, GM; Calou, IBF; Costa, RO; Lima, FAV; Lima, LAR; Lopes, MJP; Neves, KRT; Viana, GSB | 1 |
Gill, KM; Grace, AA; Sonnenschein, SF | 1 |
Chen, G; Chen, J; Chen, Y; Dai, Y; Yang, B; Yu, W | 1 |
Brito, BM; Gobira, PH; Joca, SRL; Sartim, AG | 1 |
Choudhury, ME; Kubo, M; Miyanishi, K; Nomoto, M; Tanaka, J; Watanabe, M; Yano, H | 1 |
Brosch, M; Coors, A; Fendt, M; Franke, K; Gerber, B; Kahl, E; Khalil, R; Laub, A; Michels, B | 1 |
Bakharev, B; Bobkova, N; Deev, A; Medvinskaya, N; Nesterova, I; Samokhin, A; Sengpiel, F; Tatarnikova, O; Ustyugov, AA; Vorobyov, V | 1 |
Antonio, CB; Betti, AH; da Rocha Pitta, I; do Rego, JC; do Rego, JL; Herzfeldt, V; Pitta, MGDR; Rates, SMK; Vaudry, D | 1 |
Hamzehloei, L; Rajaei, Z; Rezvani, ME | 1 |
Jalali-Nadoushan, M; Roghani, M | 1 |
Frau, L; Morelli, M; Simola, N | 1 |
Bolondi, C; Cantelli-Forti, G; Hrelia, P; Morroni, F; Sita, G; Tarozzi, A; Zolezzi Moraga, JM | 1 |
Dixit, TS; Elased, KM; Lucot, JB; Sharma, AN | 1 |
He, Q; Li, R; Liang, T; Xu, L; Zheng, N | 1 |
Dong, F; Ji, FQ; Li, WS; Sun, HM; Wu, B; Xue, H; Yan, JH; Yang, S; Zhou, DS | 1 |
Bohner, LO; Costa, AP; De Lima, TC; Lino-de-Oliveira, C; Santos, EC; Silva, CF; Vieira, C | 1 |
Ciucci, MR; Russell, JA; Schaser, AJ | 1 |
Cui, C; Hu, L; Li, Y; Sun, L | 1 |
Raju, AB; Suresh, P | 1 |
Akram, MN; Chrétien, F; Despars, G; Domenget, C; Gherardi, R; Honnorat, J; Jurdic, P; Nataf, S; Ressnikoff, D; Touret, M; Uhlrich, J; Virgone-Carlotta, A | 1 |
Aguiar, JC; Guimarães, FS; Lisboa, SF; Magesto, AC; Resstel, LB | 1 |
Bao, X; Tai, W; Wang, X; Ye, X; Zhang, D; Zhao, B | 1 |
Döbrössy, MD; Nikkhah, G; Pauly, MC; Piroth, T; Schackel, S | 1 |
Aebischer, P; Bensadoun, JC; Coune, PG; Schneider, BL | 1 |
Erbas, O; Oltulu, F; Taskiran, D | 1 |
Britto, LR; Café-Mendes, CC; Hernandes, MS; Lima, LS; Munhoz, CD; Santos, GD; Scavone, C | 1 |
Grauer, SM; Hodgson, R; Hyde, LA | 1 |
Kinney, JW; Landers, MR; van Breukelen, F | 1 |
Akseki, HS; Eliküçük, B; Erbaş, O; Taşkıran, D | 1 |
Bao, XQ; Kong, LB; Kong, XC; Sun, H; Wu, LY; Zhang, D | 1 |
Abdu-Aguye, I; Hussaini, IM; Magaji, MG; Magaji, RA; Mohammed, M; Musa, AM | 1 |
Gong, X; Liang, X; Liu, L; Wang, X; Zhang, W | 1 |
Hammond, MD; Li, J; Mancini, NS; McCullough, LD; Venna, VR | 1 |
Kilic, FS; Kulluk, D; Musmul, A | 1 |
Björklund, A; Carta, M; Devoto, P; Rogers, JT; Shin, E | 1 |
Farhan, M; Haleem, DJ | 1 |
Büchele, F; Döbrössy, M; Hackl, C; Jiang, W; Nikkhah, G; Papazoglou, A | 1 |
Chen, G; Feng, J; Feng, W; Huang, Z; Niu, J; Shi, L; Wang, Y; Ye, C; Zhu, G | 1 |
Banerjee, M; Mohanakumar, KP; Nthenge-Ngumbau, DN; Tripathy, D; Verma, P | 1 |
Capozzo, A; Mattei, C; Mazzone, P; Scarnati, E; Vitale, F | 1 |
Bähr, M; Koch, JC; Lingor, P; Saal, KA; Szegő, ÉM; Tatenhorst, L; Tönges, L | 1 |
Brosnan, RJ; Mayhew, PD; Smith, A; Soares, JH | 1 |
Campbell, JC; Chen, N; De La Cruz, P; Jeyamohan, SB; Pilitsis, JG; Shin, D | 1 |
Han, B; Jin, HJ; Song, MY; Wang, T; Zhao, H | 1 |
Liu, TD; Yang, HD; Yang, Z | 1 |
Cantelli-Forti, G; Hrelia, P; Morroni, F; Sita, G; Tarozzi, A | 1 |
Jiang, L; Long, K; Lu, F; Qu, J; Schaeffel, F; Stell, WK; Ying, H; Zheng, Y; Zhou, X | 1 |
Li, A; Zhang, F | 2 |
Auburger, G; Bez, F; Brehm, N; Carlsson, T; Cenci, MA; Gispert, S; Kern, B | 1 |
Boll, MC; Campos-Arroyo, HD; Martínez-Lazcano, JC; Montes, S; Pérez-Neri, I; Pérez-Severiano, F; Ríos, C; Rodríguez-Páez, L; Sánchez-Mendoza, MA | 1 |
Jeon, SR; Kim, YH; Shin, ES; Yoon, HH | 1 |
Ba, XH | 1 |
Gordon, R; Kaptsov, V; Makarova, E; Podolski, I; Sengpiel, F; Vorobyov, V | 1 |
Abe, H; Arimori, K; Ikeda, T; Ishida, Y; Koganemaru, G; Yasuda, K | 1 |
Chen, L; Guo, Y; Han, LN; Li, LB; Liu, J; Sun, YN; Wang, Y; Zhang, L; Zhang, QJ; Zhang, YM | 1 |
Bertolino, G; de Araujo, JE; Giorgetto, C; Kitabatake, TT; Silva, EC | 1 |
Collantes, M; Delgado, M; Ecay, M; Gago, B; Iglesias, E; Juri, C; Marín, C; Molinet-Dronda, F; Obeso, JA; Peñuelas, I; Prieto, E; Quiroga-Varela, A | 1 |
Chen, JF; Huang, F; Qu, J; Xiong, W; Yan, T; Ying, H; Zheng, F; Zhou, X | 1 |
Galeotti, N; Ghelardini, C; Peroni, D; Quattrone, A; Sanna, MD | 1 |
Duan, SJ; Han, B; Lu, Y; Wang, LJ; Wang, SY; Wang, T; Zhu, Q | 1 |
Cheng, CY; Chiu, CH; Chou, TK; Huang, WS; Huang, YS; Li, IH; Liao, MH; Ma, KH; Shiue, CY; Weng, SJ; Wu, SC | 1 |
Cui, G; Hua, F; Shen, X; Shi, H; Wang, X; Yang, X; Zhang, S; Zhang, W; Zhang, Z; Zhao, H; Zu, J | 1 |
Duan, SS; Ha, S; Li, ZA; Shi, YL; Wang, XL; Zhang, XS | 1 |
Baluchnejadmojarad, T; Kiasalari, Z; Roghani, M | 1 |
Deng, Y; Lu, J; Ma, H; Qing, H; Sun, F | 1 |
Galabov, AS; Nikolova, I; Stoyanova, A | 1 |
Avanzini, MA; Blandini, F; Bonizzi, A; Cerri, S; Fuzzati-Armentero, MT; Ghezzi, C; Greco, R; Levandis, G; Maccario, R; Mangione, AS | 1 |
Du, GH; Du, LD; He, GR; Mu, X; Yuan, X | 1 |
Czarnecka, A; Konieczny, J; Lenda, T; Lorenc-Koci, E | 1 |
Chae, MR; Han, DH; Kang, SJ; Kim, CY; Kim, JJ; Lee, SW; Park, JK; Sung, HH | 1 |
Hiratochi, M; Ijiro, T; Kaidoh, K; Oana, F; Suzuki, T; Tsuchioka, A; Yamauchi, Y | 1 |
Farhan, M; Haleem, DJ; Ikram, H; Kanwal, S | 1 |
Arai, Y; Hisamitsu, T; Nakagawasai, O; Nakajima, T; Nemoto, W; Takahashi, K; Tan-No, K | 1 |
Brauer, AF; Ciucci, MR; Kelm-Nelson, CA | 1 |
Canto-de-Souza, A; Furuya-da-Cunha, EM; Souza, RR | 1 |
Alipour Heidari, M; Dargahi, T; Faraji, A; Fraidouni, N; Haghdoost-Yazdi, H; Mahmudi, M; Piri, H | 1 |
Fisher, R; Jackson, MJ; Jenner, P; Lees, AJ; Lincoln, L; Neumeyer, J; Rose, S; Sromek, AW | 1 |
Carey, RJ; Carrera, MP; Dias, FRC; Oliveira, LR; Santos, BG; Silva, JLL | 1 |
Barkholt, P; Fabricius, K; Hansen, HH; Jelsing, J; Knudsen, LB; Mikkelsen, JD; Pyke, C; Vrang, N | 1 |
Bez, F; Cenci, MA; Francardo, V | 1 |
Armida, M; Calamandrei, G; Pezzola, A; Popoli, P; Potenza, RL; Tartaglione, AM | 1 |
Blobaum, AL; Bubser, M; Conn, PJ; Daniels, JS; Engers, DW; Hopkins, CR; Javitch, JA; Jones, CK; Lin, X; Lindsley, CW; Loch, MT; Niswender, CM; Rodriguez, AL; Thompson Gray, A | 1 |
Aliaghaei, A; Gardaneh, M; Gharib, E; Maghsoudi, N; Salehinejad, P | 1 |
Aguiar, LMV; Barros, AS; Bezerra, MM; Cavalcanti, JU; Crispim, RYG; Cristino Filho, G; de Barros Viana, GS; de Vasconcelos, SMM; Lemos, JC; Macêdo, DS; Pinheiro, TFM; Souza, RB | 1 |
Azevedo, BN; Calice da Silva, C; da Costa, JC; Machado, DC; Martins, LAM; Zimmer, ER | 1 |
Chen, W; Fu, X; Huang, L; Kong, X; Luo, Y; Pu, Z; Tang, H; Wei, S; Xing, H | 1 |
Bahri, MA; Becker, G; Garraux, G; Hustadt, F; Lemaire, C; Luxen, A; Michel, A; Plenevaux, A | 1 |
Abuirmeileh, A; Harkavyi, A; Kingsbury, A; Lever, R; Whitton, PS | 1 |
Ankoudinova, I; Bankiewicz, K; Federoff, HJ; Forsayeth, J; Guschin, D; Hadaczek, P; Horovitz, K; Johnston, LC; Maguire-Zeiss, K; Su, X | 1 |
Domanska-Janik, K; Gielecki, J; Gornicka-Pawlak, E; Janowski, M; Kozlowska, H; Lukomska, B | 1 |
Sengpiel, F; Vorobyov, V | 1 |
Glavan, G | 1 |
Bardin, L; Barret-Grévoz, C; Depoortère, R; Newman-Tancredi, A | 1 |
Alberts, JL; Ghosh, D; Johnson, MD; Mera, TO; Rothe, D; Vitek, J; Xu, W; Zhang, J | 1 |
Jadavji, NM; Metz, GA | 1 |
Daniels, WM; Di Chiara, G; Morelli, M; Schallert, T; Simola, N | 1 |
Bi, J; Gu, S; Huang, H; Wen, T; Yao, Y | 1 |
Dechant, G; Hainzer, M; Köllensperger, M; Nikkhah, G; Pallua, A; Poewe, W; Puschban, Z; Reindl, M; Stefanova, N; Wenning, GK | 1 |
Aebischer, P; Bensadoun, JC; Dusonchet, J; Schneider, BL | 1 |
Ding-Fang, C; Guo-Hua, W; Hong-Min, T; Hua-Wei, L; Jun, M; Jun-Peng, G; Shan, S; Wen-Wei, L; Xiang-Yu, W; Ya-Ling, H; Yan-Hong, T; Yi, F; Yue, F; Yun-Ke, Y | 1 |
Da Cunha, C; Ferro, MM; Gregório, ML; Silveira, JL; Vital, MA; Wietzikoski, EC | 1 |
Brus, H; Brus, R; Drab, J; Jochem, J; Körossy, E; Kostrzewa, RM; Noras, L; Nowak, P; Szkilnik, R | 1 |
Niimi, K; Takahashi, E | 1 |
Hirabayashi, H; Ishizaka, S; Matsuda, R; Nakase, H; Nishimura, F; Nonaka, J; Ouji, Y; Sakaki, T; Toriumi, H; Yamada, S; Yoshikawa, M | 1 |
Büchele, F; Döbrössy, M; Jiang, W; Nikkhah, G; Papazoglou, A | 1 |
Azar, MR; Geyer, MA; Gold, L; Marston, HM; Martin, FD; Meltzer, LT; Moore, CL; Serpa, KA; Shahid, M; Wong, EH; Young, JW | 1 |
Björklund, A; Carlsson, T; Carta, M; Kirik, D; Muñoz, A; Tronci, E | 1 |
Ballion, B; Chetrit, J; Frenois, F; Gonon, F; Murer, MG; Zold, CL | 1 |
Beal, MF; Bogdanov, M; Burke, RE; Geghman, K; Jackson-Lewis, V; Li, C; Li, Y; Liu, W; Oo, TF; Przedborski, S; Tang, Y; Wang, L; Zhou, C | 1 |
Jia, J; Li, B; Liu, L; Pan, Y; Sun, Z; Wang, H; Wang, X; Yu, F; Zhang, L | 1 |
Bilici, N; Gören, B; Korfali, E; Mimbay, Z; Oğul, E; Zarifoğlu, M | 1 |
De Jonghe, BC; Horn, CC; Matyas, K; Norgren, R | 1 |
Ali, U; Chen, L; Gui, ZH; Hui, YP; Li, Q; Liu, J; Wang, Y; Wu, ZH; Zhang, QJ | 1 |
Martens, GJ; Van Loo, KM; Van Schijndel, JE; Van Zweeden, M | 1 |
Amalric, M; Flor, PJ; Greco, B; Lopez, S; van der Putten, H | 1 |
Achaval, M; Anselmo-Franci, JA; Bagatini, PB; de David, C; Delattre, AM; Ferraz, AC; Iagher, F; Kiss, A; Marroni, NA; Rigon, P; Szawka, RE; Xavier, LL | 1 |
Johansson, SM; Modo, MM; Vernon, AC | 1 |
Ahmed, MR; Bychkov, E; Gurevich, EV | 1 |
Nakagawasai, O; Niijima, F; Onogi, H; Sato, A; Tadano, T; Tan-No, K | 1 |
Mei, J; Niu, C | 1 |
Cheng, B; Hu, W; Li, S; Liu, T; Tian, Y | 1 |
Ai, Y; Bradley, LH; Fuqua, J; Gash, DM; Gerhardt, GA; Glass, JD; Grondin, R; He, X; Huettl, P; Kelps, KA; Littrell, OM; Pomerleau, F; Richardson, A; Turchan-Cholewo, J; Zhang, Z | 1 |
Bordet, R; Destée, A; Duhamel, A; Kreisler, A; Vanbesien-Mailliot, C | 1 |
Björklund, A; Draxler, P; Grealish, S; Mattsson, B | 1 |
Baluchnejadmojarad, T; Jalali-Nadoushan, MR; Khalili, M; Kiasalari, Z; Niknam, A; Roghani, M | 1 |
Kunselman, AR; Lieu, CA; Manyam, BV; Subramanian, T; Venkiteswaran, K | 1 |
de Carvalho, CR; Duarte, FS; Horst, H; Moreira, EL; Pizzolatti, MG; Prediger, RD; Rial, D; Ribeiro-do-Valle, RM | 1 |
Chan, JS; de Jong, TR; Olivier, B; Oosting, RS; Snoeren, EM; Waldinger, MD | 1 |
Al-Amin, H; Atweh, S; Jabbur, S; Saadé, N; Sarkis, R | 2 |
Anvret, A; Belin, AC; Duester, G; Galter, D; Lindqvist, E; Ogren, SO; Pernold, K; Westerlund, M | 1 |
Cumming, P; Kjaerby, C; Knudsen, GM; Palner, M | 1 |
Bähr, M; Garrido, M; Kügler, S; Taschenberger, G; Tereshchenko, Y; Zhevtsova, Z | 1 |
Cao, G; Chen, J; Chu, CT; Gao, Y; Greenamyre, JT; Hastings, T; Hu, X; Signore, A; Weng, Z; Zhang, L; Zhu, J | 1 |
Krauss, JK; Lütjens, G; Schwabe, K | 1 |
Hashimoto, T; Himeno, E; Kira, J; LaFerla, FM; Ma, L; Miyoshi, K; Motomura, K; Nakamura, N; Ohyagi, Y; Sakae, N; Soejima, N; Tabira, T; Yamasaki, R | 1 |
Chen, JJ; Chen, LH; Chiang, PT; Hsieh, TH; Lee, HY | 1 |
Domanska-Janik, K; Drela, K; Gornicka-Pawlak, EB; Habich, A; Jablonska, A; Janowski, M; Kozlowska, H; Lukomska, B; Sypecka, J | 1 |
Af Bjerkén, S; Gerhardt, GA; Lundblad, M; Nevalainen, N; Strömberg, I | 1 |
Faraji, A; Fraidouni, N; Hadibeygi, E; Haghdoost-Yazdi, H; Movahedi, M; Vaezi, F | 1 |
Andreatini, R; Chioca, LR; Correia, D; Pereira, M; Pizzolatti, MG; Santos, AR; Siba, IP; Vital, MA | 1 |
Filli, L; Schwab, ME; Weinmann, O; Zörner, B | 1 |
Ali, U; Chen, L; Gui, ZH; Liu, J; Wang, T; Wang, Y | 1 |
Evinger, C; Horn, KG; Hui, C; Kaminer, J; Powers, AS | 1 |
Chan, YS; Chen, LW; Chu, JM; Yung, KK | 1 |
Carlsson, T; Döbrössy, M; García, J; Nikkhah, G; Winkler, C | 1 |
Geng, XC; Yin, LL; Zhu, XZ | 1 |
Anvret, A; Belin, AC; Duester, G; Felder, MR; Galter, D; Gellhaar, S; Lindqvist, E; Lundströmer, K; Pernold, K; Ran, C; Westerlund, M | 1 |
Bilge, U; Erol, K | 1 |
Champagne, DL; Daskalakis, NP; de Kloet, ER; Oitzl, MS; Schächinger, H | 1 |
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Boissier, JR; Janssen, PA; Julou, L; Loew, DM; Moller Nielsen, I; Munkvad, I; Randrup, A; Stille, G; Tedeschi, DH; Van Rossum, JM | 1 |
Brown, RE; Madge, GE; Schiller, HM | 1 |
8 review(s) available for apomorphine and Disease Models, Animal
Article | Year |
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Neural Stem/Progenitor Cell Transplantation in Parkinson's Rodent Animals: A Meta-Analysis and Systematic Review.
Topics: Animals; Apomorphine; Disease Models, Animal; Humans; Parkinson Disease; Rodentia; Stem Cell Transplantation | 2022 |
Oral r-(-)-11-o-valeryl-n-n-propylnoraporphine reverses motor deficits in mptp-treated marmosets.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Callithrix; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Male; MPTP Poisoning; Valerates | 2016 |
The evaluation of apomorphine for the treatment of erectile dysfunction.
Topics: Administration, Sublingual; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Erectile Dysfunction; Humans; Male; Randomized Controlled Trials as Topic; Treatment Failure; United States | 2012 |
[Subcutaneous apomorphine injection: rescue management of motor fluctuations associated with levodopa-therapy].
Topics: Animals; Antiparkinson Agents; Apomorphine; Circadian Rhythm; Clinical Trials as Topic; Disease Models, Animal; Dopamine Agents; Humans; Injections, Subcutaneous; Levodopa; Parkinson Disease; Receptors, Dopamine; Salvage Therapy; Self Administration | 2013 |
Experimental parkinsonism in primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Apomorphine; Basal Ganglia; Bicuculline; Cerebral Cortex; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrocoagulation; GABA Antagonists; Globus Pallidus; Humans; Models, Neurological; MPTP Poisoning; Muscle Rigidity; Neurotoxins; Parkinsonian Disorders; Primates; Substance-Related Disorders; Substantia Nigra; Tegmentum Mesencephali; Thalamus | 2001 |
Apomorphine susceptibility and animal models for psychopathology: genes and environment.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Environment; Genetic Predisposition to Disease; Genetics, Behavioral; Rats; Rats, Inbred Strains; Schizophrenia; Species Specificity; Stereotyped Behavior | 2002 |
Animal models of tardive dyskinesia: their use in the search for new treatment methods.
Topics: Age Factors; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Combinations; Drug Interactions; Dyskinesia, Drug-Induced; Guinea Pigs; Haloperidol; Haplorhini; Humans; Levodopa; Lithium; Male; Parasympatholytics; Rats; Receptors, Dopamine; Stereotyped Behavior | 1983 |
The role of dopamine in epilepsy.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Epilepsy | 1996 |
470 other study(ies) available for apomorphine and Disease Models, Animal
Article | Year |
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1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Topics: Animals; Benzamides; Binding Sites; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Erectile Dysfunction; Ferrets; Humans; Male; Models, Molecular; Molecular Structure; Oximes; Piperazines; Rats; Rats, Wistar; Receptors, Dopamine D4; Stereoisomerism; Structure-Activity Relationship | 2006 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Topics: alpha-Synuclein; Animals; Antioxidants; Apomorphine; Curcumin; Disease Models, Animal; Glutathione Peroxidase; Malondialdehyde; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Parkinson Disease; Rats; Substantia Nigra | 2022 |
5-(4-Hydroxy-3-dimethoxybenzylidene)-thiazolidinone improves motor functions and exerts antioxidant potential in hemiparkinsonian rats.
Topics: Animals; Antioxidants; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Oxidopamine; Parkinson Disease; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 2023 |
Neurobehavioral Profiles of Six Genetically-based Rat Models of Schizophrenia- related Symptoms.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Prepulse Inhibition; Rats; Rats, Brattleboro; Reflex, Startle; Schizophrenia | 2023 |
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Lacosamide; Male; Malondialdehyde; Mice; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tumor Necrosis Factor-alpha | 2023 |
Deep brain stimulation of the thalamic centromedian-parafascicular nucleus improves behavioural and neuronal traits in a rat model of Tourette.
Topics: Animals; Apomorphine; Behavior, Animal; Deep Brain Stimulation; Disease Models, Animal; Dopamine Agonists; Electrocorticography; Intralaminar Thalamic Nuclei; Male; Neostriatum; Nucleus Accumbens; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Reflex, Startle; Sensorimotor Cortex; Theta Rhythm; Tourette Syndrome | 2020 |
Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Disease Models, Animal; DNA Glycosylases; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Oxidopamine; Parkinson Disease; Stereotaxic Techniques | 2020 |
mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson's Disease.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Neurodegenerative Diseases; Oxidopamine; Parkinson Disease; Receptor, Metabotropic Glutamate 5 | 2020 |
Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: Towards a screening test for anti-compulsive drug action.
Topics: Animals; Apomorphine; Behavior, Animal; Citalopram; Conflict, Psychological; Disease Models, Animal; Dopamine Agonists; Feedback, Psychological; Motivation; Obsessive-Compulsive Disorder; Reward; Selective Serotonin Reuptake Inhibitors; Social Behavior; Zebrafish | 2020 |
Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Male; Maze Learning; Mice; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Interaction; Stereoisomerism; Stereotyped Behavior | 2020 |
L-linalool exerts a neuroprotective action on hemiparkinsonian rats.
Topics: Acyclic Monoterpenes; Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine; Lipid Peroxidation; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2020 |
Pentadecapeptide BPC 157 counteracts L-NAME-induced catalepsy. BPC 157, L-NAME, L-arginine, NO-relation, in the suited rat acute and chronic models resembling 'positive-like' symptoms of schizophrenia.
Topics: Amphetamine; Animals; Apomorphine; Arginine; Behavior, Animal; Catalepsy; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Enzyme Inhibitors; Haloperidol; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Proteins; Rats; Rats, Wistar; Schizophrenia | 2021 |
Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic Agents; Animals; Apomorphine; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2021 |
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3.
Topics: Animals; Antiviral Agents; Apomorphine; Cell Line; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Nitriles; Oxadiazoles; Oxazoles; Virus Replication | 2020 |
Restraint-induced behavioral deficits are attenuated or impaired by pre- or post-injection of apomorphine: A context-based study.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Central Nervous System Stimulants; Disease Models, Animal; Eating; Elevated Plus Maze Test; Injections, Intravenous; Male; Motor Activity; Rats, Wistar; Restraint, Physical; Stress, Psychological; Time Factors | 2020 |
Increased emissions of 50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs: A potential preclinical model for studying the affective properties of dopamine replacement therapy in Parkinson's disease.
Topics: Affect; Animals; Apomorphine; Desipramine; Disease Models, Animal; Dopamine Agents; Levodopa; Male; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Ultrasonic Waves; Vocalization, Animal | 2021 |
The Effect of Levosimendan on Two Distinct Rodent Models of Parkinson's Disease.
Topics: Animals; Apomorphine; Cardiotonic Agents; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Simendan; Substantia Nigra; Sympatholytics | 2020 |
Cortical and Striatal Electroencephalograms and Apomorphine Effects in the FUS Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apomorphine; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Electroencephalography; Male; Mice; Mice, Transgenic; Motor Neurons | 2021 |
Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson's disease: Behavioral and neurochemical evidence.
Topics: Animals; Apomorphine; Behavior, Animal; Caffeine; Corpus Striatum; Disease Models, Animal; Dopamine; Oxidopamine; Parkinson Disease; Rats; Taurine | 2021 |
Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.
Topics: Amphetamine; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Botulinum Toxins, Type A; Corpus Striatum; Disease Models, Animal; Injections; Male; Motor Activity; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats; Rats, Wistar | 2021 |
Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.
Topics: Animals; Apomorphine; Dendritic Spines; Disease Models, Animal; Dopamine Agents; Levodopa; Male; Medial Forebrain Bundle; Neurons; Nucleus Accumbens; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Statistics, Nonparametric; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2017 |
Neuroprotective effect of epidermal growth factor in experimental acrylamide neuropathy: an electrophysiological approach.
Topics: Acrylamide; Action Potentials; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Electric Stimulation; Epidermal Growth Factor; Hand Strength; Male; Mice; Mice, Inbred C57BL; Neurologic Examination; Neuroprotective Agents; Penile Erection; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Time Factors | 2017 |
Magnetic Resonance Imaging as a Noninvasive Method for Longitudinal Monitoring of Infusion Site Reactions Following Administration of a Novel Apomorphine Formulation.
Topics: Animals; Antiparkinson Agents; Apomorphine; Biomarkers; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Injection Site Reaction; Injections, Subcutaneous; Magnetic Resonance Imaging; Male; Parkinson Disease; Swine | 2017 |
Altered somatosensory cortex neuronal activity in a rat model of Parkinson's disease and levodopa-induced dyskinesias.
Topics: Action Potentials; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Glutamate Decarboxylase; Levodopa; Motor Cortex; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger; Sympatholytics; Tandem Mass Spectrometry | 2017 |
Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Exploratory Behavior; Gene Expression Regulation; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulysin; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phosphorylation; Presenilin-1 | 2017 |
Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Male; Methantheline; Mice, Inbred ICR; Morinda; Phytotherapy; Quaternary Ammonium Compounds; Rutin; Schizophrenia; Schizophrenic Psychology; Scopoletin; Stair Climbing; Stereotyped Behavior | 2017 |
An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Disease Models, Animal; Ethanol; Fabaceae; Female; Haloperidol; Mice; Mice, Inbred ICR; Motor Activity; Phytotherapy; Plant Extracts | 2017 |
Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Catalepsy; Chlorpromazine; Disease Models, Animal; Haloperidol; Herb-Drug Interactions; Hypnotics and Sedatives; Mice, Inbred BALB C; Mice, Inbred ICR; Motor Activity; Phytotherapy; Plant Extracts; Psychotic Disorders | 2017 |
Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Genotype; Humans; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Polymorphism, Genetic; Prepulse Inhibition; Stress, Psychological; Valine | 2018 |
Morin Pretreatment Attenuates Schizophrenia-Like Behaviors in Experimental Animal Models.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Immobility Response, Tonic; Ketamine; Locomotion; Male; Mice; Rotarod Performance Test; Stereotyped Behavior | 2018 |
Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acupuncture Therapy; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Electroacupuncture; Female; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Motor Activity; Motor Cortex; Parkinson Disease; Parkinson Disease, Secondary | 2018 |
Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apomorphine; Cell Death; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Exploratory Behavior; Forelimb; Male; Mesencephalon; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Motor Activity; Motor Disorders; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Thioctic Acid | 2018 |
Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Motor Activity; Nicotinic Agonists; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substantia Nigra; Varenicline | 2018 |
Differential effects of dopaminergic drugs on spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine.
Topics: Animals; Apomorphine; Area Under Curve; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Immunohistochemistry; Levodopa; Male; Methamphetamine; Motor Activity; Oxidopamine; Parkinsonian Disorders; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Topics: Abnormalities, Multiple; Amphetamine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Chromosome Deletion; Chromosomes, Human, Pair 1; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Excitatory Amino Acid Antagonists; Megalencephaly; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Phencyclidine; Phenotype; Prepulse Inhibition; Quinpirole; Receptors, Dopamine; Schizophrenia; Ventral Tegmental Area | 2017 |
A small dose of apomorphine counteracts the deleterious effects of middle cerebral artery occlusion in different models.
Topics: Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonists; Infarction, Middle Cerebral Artery; Male; Mice; Muscle Strength; Neurons; Neuroprotective Agents; Rats; Rats, Wistar | 2017 |
Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Hydrogen Sulfide; KATP Channels; Male; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Potassium Channels; Rats; Rats, Wistar; Substantia Nigra | 2018 |
Changes in Male Rat Sexual Behavior and Brain Activity Revealed by Functional Magnetic Resonance Imaging in Response to Chronic Mild Stress.
Topics: Animals; Apomorphine; Brain; Depression; Disease Models, Animal; Erectile Dysfunction; Female; Magnetic Resonance Imaging; Male; Penile Erection; Rats; Rats, Wistar; Sexual Behavior | 2018 |
Pirouetting pigs: A large non-primate animal model based on unilateral 6-hydroxydopamine lesioning of the nigrostriatal pathway.
Topics: Amphetamine; Animals; Apomorphine; Biophysics; Central Nervous System Stimulants; Corpus Striatum; Deep Brain Stimulation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Functional Laterality; Magnetic Resonance Imaging; Neural Pathways; Oxidopamine; Parkinsonian Disorders; Substantia Nigra; Swine; Swine, Miniature; Sympatholytics; Tyrosine 3-Monooxygenase | 2018 |
Analysis of respiratory movements in a mouse model of late Parkinson's disease submitted to stress.
Topics: Animals; Apomorphine; Cineradiography; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Respiration; Stress, Physiological; Sympatholytics | 2018 |
Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Electroacupuncture; Functional Laterality; Male; Medial Forebrain Bundle; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Subthalamic Nucleus; Tyrosine 3-Monooxygenase; Up-Regulation; Vesicular Glutamate Transport Protein 1 | 2018 |
Identification of metabolite biomarkers for L-DOPA-induced dyskinesia in a rat model of Parkinson's disease by metabolomic technology.
Topics: Animals; Antiparkinson Agents; Apomorphine; Arachidonic Acids; Biomarkers; Cannabinoid Receptor Agonists; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dyskinesia, Drug-Induced; Endocannabinoids; Glycerides; Levodopa; Male; Metabolome; Metabolomics; Motor Activity; Oxidopamine; Parkinsonian Disorders; Polyunsaturated Alkamides; Rats, Sprague-Dawley | 2018 |
Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson's disease: behavioral, histological and biochemical studies.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hydrogen Sulfide; Male; Malondialdehyde; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Postural Balance; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase; Sympatholytics | 2018 |
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Hyperuricemia; Male; Mental Disorders; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Oxonic Acid; Parkinson Disease, Secondary; Rotarod Performance Test; Tyrosine 3-Monooxygenase; Uric Acid | 2019 |
Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Electroretinography; Mice; Mice, Inbred C57BL; Mice, Knockout; Myopia; Receptors, Dopamine D1; Retina; Sensory Deprivation | 2018 |
Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease.
Topics: Animals; Apomorphine; Biphenyl Compounds; Corpus Striatum; Disease Models, Animal; Lignans; Male; Mice; Microinjections; Motor Activity; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidopamine; Parkinson Disease, Secondary; Postural Balance; Substantia Nigra; Tyrosine 3-Monooxygenase | 2018 |
Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Cell Differentiation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Functional Laterality; LIM-Homeodomain Proteins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microdialysis; Oxidopamine; Parkinson Disease, Secondary; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2018 |
Involvement of prelimbic 5-HT
Topics: Animals; Anxiety; Apomorphine; Desipramine; Disease Models, Animal; Dopamine Agents; Enzyme Inhibitors; Exploratory Behavior; Functional Laterality; Male; Maze Learning; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Agents; Sympatholytics | 2018 |
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Topics: alpha-Synuclein; Animals; Apomorphine; Brain; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dopaminergic Neurons; Humans; Lipopolysaccharides; Male; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2018 |
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; Nerve Degeneration; Nod2 Signaling Adaptor Protein; Oxidopamine; Parkinson Disease, Secondary; Reactive Oxygen Species | 2018 |
Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Encephalitis; Exploratory Behavior; Lipid Peroxidation; Male; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Stereotyped Behavior; Swimming; Sympatholytics; Tyrosine 3-Monooxygenase; Vitamin D | 2018 |
State-dependent effects of the D
Topics: Animals; Apomorphine; Aripiprazole; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopaminergic Neurons; Electroencephalography; Haloperidol; Male; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Ventral Tegmental Area | 2019 |
Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.
Topics: Animals; Apomorphine; Basolateral Nuclear Complex; Disease Models, Animal; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Erectile Dysfunction; Male; Penile Erection; Rats; Rats, Wistar; Receptors, Dopamine D2; Sexual Behavior, Animal; Stress, Psychological | 2019 |
Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Apomorphine; Arginine; Capsaicin; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Exploratory Behavior; Glutamic Acid; Male; Microinjections; Nitric Oxide; Nitroprusside; Rats; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Swimming | 2019 |
Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model.
Topics: Animals; Apomorphine; Behavior Rating Scale; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Male; Motor Activity; Nerve Degeneration; Parkinson Disease; Rats, Wistar; Substantia Nigra | 2019 |
Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Male; Medicine, Traditional; Mice; Mice, Inbred C57BL; Plant Extracts; Plant Roots; Prepulse Inhibition; Rats; Rats, Wistar; Rhodiola; Sensory Gating | 2019 |
Loss of Midbrain Dopamine Neurons and Altered Apomorphine EEG Effects in the 5xFAD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Electroencephalography; Male; Mesencephalon; Mice; Mice, Transgenic | 2019 |
PT-31, a putative α2-adrenoceptor agonist, is effective in schizophrenia cognitive symptoms in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Cognition; Disease Models, Animal; Dopamine Agonists; Imidazolidines; Male; Memory; Memory Disorders; Memory, Long-Term; Mice; Mice, Inbred Strains; Rats; Rats, Wistar; Receptors, Adrenergic; Schizophrenia; Schizophrenic Psychology | 2019 |
Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson's disease.
Topics: Animals; Apomorphine; Cymenes; Disease Models, Animal; Male; Memory Disorders; Motor Activity; Oxidative Stress; Parkinson Disease; Physical Conditioning, Animal; Rats; Rats, Wistar | 2019 |
Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rotation; Substantia Nigra; Thioctic Acid | 2013 |
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dynorphins; Early Growth Response Protein 1; Enkephalins; Functional Laterality; Gene Expression Regulation; Male; Motor Neurons; Movement; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2013 |
Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.
Topics: Actinin; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Caspase 3; Disease Models, Animal; DNA Fragmentation; Dopamine Agonists; Glutathione; Glutathione Reductase; Glutathione Transferase; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rotarod Performance Test; Rotation; Sulfoxides; Tyrosine 3-Monooxygenase | 2013 |
Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dopamine Agonists; Glucagon-Like Peptide 1; Liraglutide; Male; Mice; Psychotic Disorders; Pyrazines; Sitagliptin Phosphate; Statistics, Nonparametric; Triazoles | 2013 |
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Isoflavones; Male; Malondialdehyde; Microtubule-Associated Proteins; Motor Activity; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Oxidoreductases; Protein Deglycase DJ-1; Rats; Rats, Wistar; Substantia Nigra; Time Factors | 2013 |
Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells.
Topics: Amnion; Analysis of Variance; Animals; Apomorphine; Brain-Derived Neurotrophic Factor; Cell Differentiation; Culture Media, Conditioned; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fetal Blood; Fetus; Flow Cytometry; Homeodomain Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptor, trkB; RNA, Messenger; Stereotyped Behavior; Transcription Factors; Tyrosine 3-Monooxygenase | 2013 |
A proposal for refining the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramine; Disease Models, Animal; Fluoxetine; Imipramine; Immobility Response, Tonic; Male; Mice; Principal Component Analysis; Swimming; Time Factors | 2013 |
Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Electric Stimulation; Forelimb; Functional Laterality; Hypoglossal Nerve; Male; Movement; Muscle Strength; Neurotoxins; Oxidopamine; Parkinson Disease; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Time Factors; Tongue; Tongue Diseases; Tyrosine 3-Monooxygenase | 2013 |
Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal.
Topics: Action Potentials; Analgesics, Opioid; Animals; Apomorphine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agents; Dopaminergic Neurons; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward; Signal Transduction; Substance Withdrawal Syndrome; Time Factors; Ventral Tegmental Area | 2014 |
Antidopaminergic effects of leucine and genistein on shizophrenic rat models.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopaminergic Neurons; Genistein; Leucine; Motor Activity; Protein Kinase Inhibitors; Rats; Rats, Wistar; Schizophrenia; Stereotyped Behavior | 2013 |
Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic Agents; Animals; Antigens, Differentiation; Apomorphine; Cell Communication; Cell Count; Disease Models, Animal; Dopamine Agonists; Female; Green Fluorescent Proteins; Imaging, Three-Dimensional; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Confocal; Neurons; Oxidopamine; Parkinson Disease; Receptors, Interleukin-8A; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats.
Topics: Animals; Anxiety; Apomorphine; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; GABA-A Receptor Antagonists; Male; Maze Learning; Nitric Oxide Synthase; Oxadiazoles; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models.
Topics: Animals; Apomorphine; Benzeneacetamides; Cell Line; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Encephalitis; Enzyme Activation; Enzyme Activators; Exploratory Behavior; Lipopolysaccharides; Male; Mice; Motor Activity; Parkinson Disease; Phenols; Rats; Rats, Wistar; src-Family Kinases | 2013 |
Donor age dependent graft development and recovery in a rat model of Huntington's disease: histological and behavioral analysis.
Topics: Age Factors; Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Female; Fetal Tissue Transplantation; Globus Pallidus; Huntington Disease; Motor Activity; Neurons; Quinolinic Acid; Rats, Sprague-Dawley; Recovery of Function | 2013 |
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apomorphine; Disease Models, Animal; Dopaminergic Neurons; Exploratory Behavior; Female; Forelimb; Genetic Vectors; Golgi Apparatus; Humans; Male; Mice; Mutation; Parkinson Disease; rab1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Suppression of exaggerated neuronal oscillations by oxytocin in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Electroencephalography; Electrophysiological Phenomena; Male; Neostriatum; Neurons; Oxytocin; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotation | 2013 |
Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Minocycline; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nerve Degeneration; NF-kappa B; Oxidopamine; Parkinson Disease; Substantia Nigra; Tumor Necrosis Factor-alpha | 2013 |
MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348.
Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Apomorphine; Benzothiazoles; Disease Models, Animal; Dopamine Agonists; Male; Mice; Mice, Transgenic; Motor Activity; Parkinson Disease; Pramipexole; Prepulse Inhibition; Pyrimidines; Triazoles | 2014 |
Forced exercise before or after induction of 6-OHDA-mediated nigrostriatal insult does not mitigate behavioral asymmetry in a hemiparkinsonian rat model.
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Forelimb; Functional Laterality; Male; Oxidopamine; Parkinsonian Disorders; Physical Conditioning, Animal; Psychomotor Performance; Rats; Rats, Long-Evans; Stereotyped Behavior; Substantia Nigra | 2014 |
Antipsychotic-like effect of trimetazidine in a rodent model.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Male; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Treatment Outcome; Trimetazidine | 2013 |
Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.
Topics: alpha-Synuclein; Animals; Apomorphine; Benzeneacetamides; Cell Death; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Phenols; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Repressor Proteins; Signal Transduction; Transcription Factors; Tyrosine 3-Monooxygenase | 2014 |
Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Euphorbiaceae; Female; Grooming; Haloperidol; Male; Medicine, African Traditional; Methanol; Mice; Phytotherapy; Plant Bark; Plant Extracts; Plant Roots; Solvents; Stereotyped Behavior; Swimming; Water | 2014 |
Relation between microPET imaging and rotational behavior in a parkinsonian rat model induced by medial forebrain bundle axotomy.
Topics: Animals; Apomorphine; Axotomy; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Functional Laterality; Male; Medial Forebrain Bundle; Parkinson Disease; Raclopride; Radionuclide Imaging; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2014 |
Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke.
Topics: AMP-Activated Protein Kinases; Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonists; Infarction, Middle Cerebral Artery; Male; Metformin; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neovascularization, Pathologic; Neuroglia; Neuroprotective Agents; Physical Stimulation; Random Allocation; Recovery of Function; Stroke; Vascular Endothelial Growth Factor A | 2014 |
Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice.
Topics: Adjuvants, Immunologic; Amphetamine; Animals; Apomorphine; Catalepsy; Central Nervous System Stimulants; Dehydroepiandrosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Mice; Schizophrenia; Statistics, Nonparametric; Time Factors | 2014 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benzylamines; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Motor Activity; Nerve Degeneration; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Stereotyped Behavior | 2014 |
Inhibition of apomorphine-induced behavioral sensitization in rats pretreated with fluoxetine.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Fluoxetine; Male; Motor Activity; Psychoses, Substance-Induced; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2015 |
Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Embryo, Mammalian; Female; Fetal Tissue Transplantation; Graft Survival; Green Fluorescent Proteins; Medial Forebrain Bundle; Nerve Fibers; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Transgenic; Time Factors | 2014 |
PEGylated rhFGF-2 conveys long-term neuroprotection and improves neuronal function in a rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Apoptosis; Astrocytes; Behavior, Animal; Biological Availability; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Fibroblast Growth Factor 2; Glial Fibrillary Acidic Protein; Male; Neostriatum; Neuroprotective Agents; Oxidopamine; Parkinson Disease; PC12 Cells; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection.
Topics: Adrenergic Agents; Amphetamine; Animals; Apomorphine; Brain; Cell Differentiation; Disease Models, Animal; Dopamine; Embryonic Stem Cells; Functional Laterality; Magnetics; Male; Medial Forebrain Bundle; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2014 |
Continuous stimulation of the pedunculopontine tegmental nucleus at 40 Hz affects preparative and executive control in a delayed sensorimotor task and reduces rotational movements induced by apomorphine in the 6-OHDA parkinsonian rat.
Topics: Animals; Apomorphine; Deep Brain Stimulation; Disease Models, Animal; Dopamine Agonists; Executive Function; Male; Movement; Oxidopamine; Parkinsonian Disorders; Pedunculopontine Tegmental Nucleus; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Treatment Outcome | 2014 |
Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscle Strength; Oxidopamine; Parkinson Disease; Protein Kinase Inhibitors; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2014 |
Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.
Topics: Analgesics, Opioid; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Fentanyl; Lung Compliance; Muscle Rigidity; Rabbits; Thoracic Wall | 2014 |
Place conditioning to apomorphine in rat models of Parkinson's disease: differences by dose and side-effect expression.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Functional Laterality; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotation; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 2014 |
A potential target for the treatment of Parkinson's disease: effect of lateral habenula lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Habenula; Homovanillic Acid; Male; Medial Forebrain Bundle; Neurosurgery; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2014 |
[Effect of dopamine receptor agonist apomorphine on scopolamine induced memory deficits in mice].
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Male; Memory Disorders; Mice; Scopolamine | 2014 |
Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.
Topics: Animals; Apomorphine; Apoptosis; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Glutathione Reductase; Glutathione Transferase; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Rotarod Performance Test; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus).
Topics: Animals; Apomorphine; Benzazepines; Disease Models, Animal; Disease Progression; Dopamine Agonists; Dopamine Antagonists; Follow-Up Studies; Guinea Pigs; Myopia; Refraction, Ocular; Sulpiride; Treatment Outcome | 2014 |
Dual regulating effects of gastrodin on extracellular dopamine concentration in rats models of Tourette's syndrome.
Topics: Animals; Apomorphine; Benzyl Alcohols; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Glucosides; Haloperidol; Homovanillic Acid; Male; Nitriles; Rats; Stereotyped Behavior; Tourette Syndrome; Up-Regulation | 2015 |
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.
Topics: alpha-Synuclein; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Dyskinesias; Extracellular Signal-Regulated MAP Kinases; Humans; Locomotion; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Parkinsonian Disorders; Phosphorylation; Point Mutation; Post-Synaptic Density; Prions; Promoter Regions, Genetic; Protein Processing, Post-Translational; Stereotyped Behavior; Substantia Nigra; Transgenes | 2015 |
Sub-chronic copper pretreatment reduces oxidative damage in an experimental Huntington's disease model.
Topics: Animals; Apomorphine; Copper; Disease Models, Animal; gamma-Aminobutyric Acid; Huntington Disease; Lipid Peroxidation; Male; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
A rat model of striatonigral degeneration generated by simultaneous injection of 6-hydroxydopamine into the medial forebrain bundle and quinolinic acid into the striatum.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Glucose; Injections, Intraperitoneal; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Quinolinic Acid; Rats; Rats, Wistar; Striatonigral Degeneration; Touch | 2014 |
Therapeutic effects of GM1 on Parkinson's disease in rats and its mechanism.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Female; G(M1) Ganglioside; Gene Expression Regulation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; RNA, Messenger; Stereotyped Behavior | 2016 |
Neuroprotective effects of hydrated fullerene C60: cortical and hippocampal EEG interplay in an amyloid-infused rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Apomorphine; Cerebral Cortex; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Fullerenes; Hippocampus; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Time Factors | 2015 |
Dual ameliorative effects of Ningdong granule on dopamine in rat models of Tourette's syndrome.
Topics: Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Drugs, Chinese Herbal; Male; Medicine, Chinese Traditional; Nitriles; Rats; Rats, Wistar; Receptors, Dopamine D2; Tourette Syndrome; Up-Regulation | 2015 |
Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Topics: Animals; Antiparkinson Agents; Apomorphine; Benzothiazoles; Disease Models, Animal; Infusions, Intraventricular; Injections, Intraperitoneal; Male; Parkinsonian Disorders; Pilocarpine; Pramipexole; Rats; Rats, Sprague-Dawley; Ventral Striatum | 2015 |
Activation of serotonin(2C) receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Depression; Disease Models, Animal; Dopamine Agonists; Exploratory Behavior; Food Preferences; Functional Laterality; Habenula; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Agents; Substantia Nigra; Sucrose; Swimming | 2015 |
Behavioural profile of Wistar rats with unilateral striatal lesion by quinolinic acid (animal model of Huntington disease) post-injection of apomorphine and exposure to static magnetic field.
Topics: Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Functional Laterality; Huntington Disease; Magnetic Fields; Male; Motor Activity; Neurons; Quinolinic Acid; Rats; Rats, Wistar; Statistics as Topic | 2015 |
Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain; Carbon Radioisotopes; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Functional Laterality; Longitudinal Studies; Magnetic Resonance Imaging; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrabenazine | 2015 |
Daily Injection But Not Continuous Infusion of Apomorphine Inhibits Form-Deprivation Myopia in Mice.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Drug Administration Schedule; Infusions, Parenteral; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Myopia; Refraction, Ocular; Sensory Deprivation | 2015 |
Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.
Topics: Analgesics, Non-Narcotic; Animals; Anti-HIV Agents; Apomorphine; Calcium Channel Blockers; Cell Line, Tumor; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; ELAV Proteins; ELAV-Like Protein 4; Exploratory Behavior; Gene Expression Regulation; Hyperalgesia; Male; Mice; Motor Activity; Neuroblastoma; Pain; Pain Threshold; Peripheral Nervous System Diseases; Ryanodine Receptor Calcium Release Channel; Spinal Cord; Zalcitabine | 2015 |
Coadministration of hydroxysafflor yellow A with levodopa attenuates the dyskinesia.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Chalcone; Disease Models, Animal; Levodopa; Male; Motor Activity; Olfaction Disorders; Oxidopamine; Parkinson Disease; Quinones; Rats; Receptors, Dopamine D3; Time Factors | 2015 |
PET Imaging of Serotonin Transporters With 4-[(18)F]-ADAM in a Parkinsonian Rat Model With Porcine Neural Xenografts.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; Nerve Degeneration; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra; Swine; Transplantation, Heterologous | 2016 |
Intranigral administration of substance P receptor antagonist attenuated levodopa-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Administration Schedule; Dyskinesia, Drug-Induced; Gene Expression Regulation; Indoles; Levodopa; Male; MAP Kinase Signaling System; Motor Activity; Neurokinin-1 Receptor Antagonists; Oxidopamine; Parkinson Disease; Piperidines; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 2015 |
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
Topics: Abietanes; Animals; Apomorphine; Apoptosis; Cell Survival; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression Regulation; Glutathione; Humans; Male; Mice; Mice, Inbred C57BL; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidopamine; Reactive Oxygen Species; Signal Transduction; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Topics: Animals; Apomorphine; Catalase; Corpus Striatum; Disease Models, Animal; Ethanol; Glutathione; Hypericum; Male; Malondialdehyde; Mitogen-Activated Protein Kinases; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Plant Extracts; Rats, Wistar; Reaction Time; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Water | 2016 |
Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.
Topics: Age Factors; alpha-Synuclein; Amino Acid Substitution; Animals; Apomorphine; Brain; Disease Models, Animal; Dopaminergic Neurons; Immunohistochemistry; Male; Mutant Proteins; Mutation, Missense; Parkinsonian Disorders; Phosphorylation; Protein Aggregation, Pathological; Rats; Rats, Transgenic; Rats, Wistar; Recombinant Proteins; Torsion Abnormality | 2015 |
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Guanidine; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Survival Analysis; Treatment Outcome | 2015 |
Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects.
Topics: Animals; Apomorphine; Behavior, Animal; Blood-Brain Barrier; Carotid Arteries; Cell Count; Cell Tracking; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Injections, Intra-Arterial; Injections, Intraventricular; Male; Mannitol; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neurons; Osmolar Concentration; Oxidopamine; Parkinson Disease, Secondary; Permeability; Rats; Rats, Wistar | 2015 |
Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Male; Molecular Structure; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Sprague-Dawley; Tremor | 2016 |
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Biogenic Monoamines; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Indazoles; Levodopa; Locomotion; Male; Movement Disorders; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidopamine; Rats; Rats, Wistar; Time Factors | 2015 |
New Methodology for Investigating Ejaculation Dysfunction: Measuring Intraluminal Seminal Vesicle Pressure in Rats with a Telemetric Device.
Topics: Animals; Apomorphine; Disease Models, Animal; Ejaculation; Indoles; Male; Penis; Pressure; Rats; Rats, Sprague-Dawley; Seminal Vesicles; Sexual Behavior; Sulfonamides; Tamsulosin; Telemetry; Urological Agents | 2015 |
Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions.
Topics: Animals; Antiparkinson Agents; Apomorphine; Azepines; Benzothiazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Ergolines; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pramipexole; Quinolines; Receptors, Dopamine D2; Tetrahydronaphthalenes; Thiophenes | 2015 |
Apomorphine induced conditioned place preference and sensitization is greater in rats exposed to unpredictable chronic mild stress.
Topics: Animals; Apomorphine; Behavior, Addictive; Behavior, Animal; Central Nervous System Stimulants; Chronic Disease; Conditioning, Psychological; Disease Models, Animal; Male; Motor Activity; Rats, Wistar; Reinforcement, Psychology; Stress, Psychological | 2015 |
Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system.
Topics: Animals; Apomorphine; Corpus Striatum; Depression; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopaminergic Neurons; Imipramine; Male; Mice; Motor Activity; Nucleus Accumbens; Olfactory Bulb; Receptors, Dopamine D2; Smell; Tyrosine 3-Monooxygenase | 2016 |
Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Carbidopa; Communication Disorders; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Combinations; Fourier Analysis; Levodopa; Male; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Stereotyped Behavior; Time Factors; Ultrasonics; Vocalization, Animal | 2016 |
Rat exposure in mice with neuropathic pain induces fear and antinociception that is not reversed by 5-HT2C receptor activation in the dorsal periaqueductal gray.
Topics: Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; Male; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Pyrazines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Sciatica; Serotonin Receptor Agonists | 2016 |
Pretreatment with potassium channel blockers of 4-aminopyridine and tetraethylammonium attenuates behavioural symptoms of Parkinsonism induced by intrastriatal injection of 6-hydroxydopamine; the role of lipid peroxidation.
Topics: 4-Aminopyridine; Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Functional Laterality; Male; Mental Disorders; Motor Activity; Oxidopamine; Parkinsonian Disorders; Postural Balance; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium; Thiazolidinediones | 2016 |
Post-trial dopaminergic modulation of conditioned catalepsy: A single apomorphine induced increase/decrease in dopaminergic activation immediately following a conditioned catalepsy response can reverse/enhance a haloperidol conditioned and sensitized cata
Topics: Analysis of Variance; Animals; Apomorphine; Catalepsy; Conditioning, Classical; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Rats, Wistar | 2016 |
Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Body Weight; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopaminergic Neurons; Glucagon-Like Peptide-1 Receptor; Liraglutide; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease | 2016 |
Aberrant self-grooming as early marker of motor dysfunction in a rat model of Huntington's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Grooming; Huntington Disease; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2016 |
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
Topics: Allosteric Regulation; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Brain; Catalepsy; Disease Models, Animal; Dopamine Agonists; Forelimb; Glutamic Acid; Haloperidol; HEK293 Cells; Humans; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transfection | 2016 |
Dopaminergic Induction of Umbilical Cord Mesenchymal Stem Cells by Conditioned Medium of Choroid Plexus Epithelial Cells Reduces Apomorphine-Induced Rotation in Parkinsonian Rats.
Topics: Animals; Apomorphine; Cell Differentiation; Cells, Cultured; Choroid Plexus; Culture Media, Conditioned; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Epithelial Cells; Humans; Mesenchymal Stem Cells; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotation; Umbilical Cord | 2016 |
Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Motor Activity; Nitrites; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2017 |
Dissociation between dopaminergic response and motor behavior following intrastriatal, but not intravenous, transplant of bone marrow mononuclear stem cells in a mouse model of Parkinson's disease.
Topics: Administration, Intravenous; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Green Fluorescent Proteins; Male; Medial Forebrain Bundle; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Motor Activity; Oxidopamine; Parkinson Disease; Rotarod Performance Test; Substantia Nigra | 2017 |
Oxoisoaporphine alkaloid derivative 8-1 reduces Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Apomorphine; Benzodioxoles; Caenorhabditis elegans; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Oxidative Stress; Peptide Fragments; Phthalazines | 2017 |
Comparative assessment of 6-[
Topics: Animals; Apomorphine; Aromatic-L-Amino-Acid Decarboxylases; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Male; Neostriatum; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Stereotyped Behavior; Tyrosine | 2017 |
The CRF-like peptide urocortin produces a long-lasting recovery in rats made hemiparkinsonian by 6-hydroxydopamine or lipopolysaccharide.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Hydroxydopamines; Lipopolysaccharides; Male; Microdialysis; Parkinson Disease, Secondary; Rats; Rats, Wistar; Recovery of Function; Time Factors; Tyrosine 3-Monooxygenase; Urocortins | 2008 |
Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Dependovirus; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Forelimb; Gene Expression; Gene Expression Profiling; Genetic Therapy; Genetic Vectors; Humans; Hydroxydopamines; Immunohistochemistry; Interleukin-10; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra | 2008 |
Structural and functional characteristic of a model for deep-seated lacunar infarct in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Infarction; Bromodeoxyuridine; Cell Proliferation; Discrimination Learning; Disease Models, Animal; Male; Motor Activity; Nerve Tissue Proteins; Neuropsychological Tests; Ouabain; Psychomotor Performance; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors | 2008 |
Apomorphine-induced differences in cortical and striatal EEG and their glutamatergic mediation in 6-hydroxydopamine-treated rats.
Topics: Alpha Rhythm; Animals; Apomorphine; Behavior, Animal; Beta Rhythm; Cerebral Cortex; Corpus Striatum; Delta Rhythm; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Osmotic Fragility; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Theta Rhythm | 2008 |
Intermittent L-DOPA treatment differentially alters synaptotagmin 4 and 7 gene expression in the striatum of hemiparkinsonian rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Functional Laterality; Gene Expression; Levodopa; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; RNA, Messenger; Synaptotagmins; Time Factors | 2008 |
Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds.
Topics: Animals; Antiemetics; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dogs; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Partial Agonism; Male; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Vomiting | 2008 |
Objective quantification of arm rigidity in MPTP-treated primates.
Topics: Animals; Antiparkinson Agents; Apomorphine; Arm; Deep Brain Stimulation; Disease Models, Animal; Electromyography; Electronic Data Processing; Female; Macaca mulatta; MPTP Poisoning; Muscle Rigidity; Muscle, Skeletal; Range of Motion, Articular | 2009 |
Both pre- and post-lesion experiential therapy is beneficial in 6-hydroxydopamine dopamine-depleted female rats.
Topics: Animals; Apomorphine; Corticosterone; Disease Models, Animal; Dopamine; Environment; Exploratory Behavior; Female; Functional Laterality; Hippocampus; Locomotion; Microtubule-Associated Proteins; Motor Skills; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Rats; Rats, Long-Evans; Tyrosine 3-Monooxygenase | 2009 |
Priming of rotational behavior by a dopamine receptor agonist in Hemiparkinsonian rats: movement-dependent induction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Enzyme Inhibitors; Functional Laterality; Male; Metyrapone; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Restraint, Physical; Rotarod Performance Test; Rotation; Time Factors | 2009 |
Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Movement; Cells, Cultured; Disease Models, Animal; Dopamine; Genetic Therapy; Maze Learning; Medial Forebrain Bundle; Motor Activity; Nerve Degeneration; Neurogenesis; Neurons; Neurotrophin 3; Oxidopamine; Parkinsonian Disorders; Rats; Stem Cell Transplantation; Stem Cells; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response.
Topics: Analysis of Variance; Animals; Apomorphine; Brain; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Levodopa; Male; Motor Activity; Multiple System Atrophy; Random Allocation; Rats; Rats, Wistar; Transplantation, Homologous | 2009 |
Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Dependovirus; Disease Models, Animal; Dopamine; Female; Gene Expression; Green Fluorescent Proteins; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2009 |
New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antibodies; Antiparkinson Agents; Apomorphine; Chemokine CX3CL1; Disease Models, Animal; DNA Nucleotidylexotransferase; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Levodopa; Male; Mental Disorders; Nerve Tissue Proteins; Parkinson Disease; Rats; Rats, Sprague-Dawley; Reaction Time; Stereotyped Behavior; Substantia Nigra; Tyrosine 3-Monooxygenase | 2011 |
Nicotine induces sensitization of turning behavior in 6-hydroxydopamine lesioned rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Functional Laterality; Ganglionic Stimulants; Male; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Time Factors | 2009 |
Histaminergic activity in a rodent model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Apomorphine; Brain; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Histamine; Histamine Antagonists; Locomotion; Male; Mouth Abnormalities; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2009 |
Combination of modified SHIRPA and pharmacological approach uncovers neuronal alteration in senescence-accelerated mouse prone 6 (SAMP6) strain.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Hindlimb Suspension; Mice; Motor Activity; Neurons; Osteoporosis; Phenotype; Receptors, Dopamine | 2009 |
Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells: necessity of immunosuppressive treatment for sustained improvement.
Topics: Animals; Apomorphine; Corpus Striatum; Cyclosporine; Disease Models, Animal; Embryonic Stem Cells; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxidopamine; Parkinson Disease; Stem Cell Transplantation; Time Factors; Transplantation, Homologous; Tyrosine 3-Monooxygenase | 2009 |
Ketamine anaesthesia interferes with the quinolinic acid-induced lesion in a rat model of Huntington's disease.
Topics: Anesthetics, Inhalation; Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Huntington Disease; Isoflurane; Ketamine; Neurons; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2009 |
Asenapine effects in animal models of psychosis and cognitive function.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Attention; Benzodiazepines; Cognition; Dibenzocycloheptenes; Disease Models, Animal; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Male; Olanzapine; Psychotic Disorders; Rats; Rats, Sprague-Dawley; Risperidone | 2009 |
Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model.
Topics: Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2009 |
D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Antiparkinson Agents; Apomorphine; Benserazide; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2009 |
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Topics: Age Factors; Animals; Antiparkinson Agents; Apomorphine; Brain; Chromosomes, Artificial, Bacterial; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Gene Transfer Techniques; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Levodopa; Mice; Mice, Transgenic; Movement Disorders; Mutation, Missense; Neurons; Nomifensine; Parkinson Disease; Protein Serine-Threonine Kinases | 2009 |
Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; Dopamine; Dyskinesias; Electroacupuncture; Enkephalins; Glutamate Decarboxylase; Male; Medial Forebrain Bundle; Motor Activity; Neurons; Parkinsonian Disorders; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Substance P; Tyrosine 3-Monooxygenase | 2009 |
Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apomorphine; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Meloxicam; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Thiazines; Thiazoles | 2009 |
Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.
Topics: Animals; Antineoplastic Agents; Apomorphine; Behavior, Animal; Cisplatin; Disease Models, Animal; Eating; Emetics; Injections, Intraperitoneal; Kaolin; Male; Neurons, Afferent; Pica; Pons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 2009 |
Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Locus Coeruleus; Male; Movement; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Substantia Nigra; Tyrosine 3-Monooxygenase | 2010 |
Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.
Topics: Animals; Apomorphine; Brain; Disease Models, Animal; Gene Expression Profiling; Kv Channel-Interacting Proteins; Male; Membrane Proteins; Microarray Analysis; Phenotype; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia; Species Specificity | 2010 |
Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Topics: Allosteric Regulation; Animals; Apomorphine; Benzhydryl Compounds; Catalepsy; Disease Models, Animal; Haloperidol; Male; Mice; Mice, Knockout; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Reaction Time; Receptors, Metabotropic Glutamate; Stereotyped Behavior | 2010 |
Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease.
Topics: Animals; Apomorphine; Brain; Cell Membrane; Disease Models, Animal; Dopamine; Dopamine Agonists; Fatty Acids, Omega-3; Lipid Peroxidation; Male; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Treatment Outcome; Tyrosine 3-Monooxygenase | 2010 |
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apomorphine; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Dopamine Agonists; Iron; Magnetic Resonance Imaging; Male; Mesencephalon; Motor Activity; Neurons; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2010 |
Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia.
Topics: Animals; Animals, Newborn; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; G-Protein-Coupled Receptor Kinases; HEK293 Cells; Hippocampus; Humans; Male; Mitogen-Activated Protein Kinase 3; Motor Activity; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics; Signal Transduction | 2011 |
Effect of non-selective dopaminergic receptor agonist on disrupted maternal behavior in olfactory bulbectomized mice.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Depression; Disease Models, Animal; Dopamine Agonists; Exploratory Behavior; Female; Food Preferences; Maternal Behavior; Mice; Olfactory Bulb; Sexual Behavior, Animal; Sucrose; Sweetening Agents | 2010 |
Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; Male; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics; Ubiquitin-Protein Ligases; Up-Regulation | 2010 |
Erectile function restoration after repair of excised cavernous nerves by autologous vein graft in rats.
Topics: Animals; Apomorphine; Disease Models, Animal; Erectile Dysfunction; Male; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Transplantation, Autologous; Veins | 2010 |
Dopamine neuron stimulating actions of a GDNF propeptide.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Isoflurane; Male; Nerve Growth Factors; Neurons; Oligopeptides; Oxidopamine; Rats; Rats, Inbred F344; Signal Transduction; Substantia Nigra | 2010 |
Differing short-term neuroprotective effects of the fibrates fenofibrate and bezafibrate in MPTP and 6-OHDA experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Apomorphine; Bezafibrate; Cell Count; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Fenofibrate; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Statistics, Nonparametric; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2010 |
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Female; Mice; Nerve Degeneration; Neural Pathways; Neuropsychological Tests; Oxidopamine; Parkinson Disease; Substantia Nigra; Sympatholytics | 2010 |
Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism.
Topics: Administration, Oral; Animals; Anthocyanins; Antiparkinson Agents; Apomorphine; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Lipid Peroxidation; Male; Mesencephalon; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2010 |
A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Benserazide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Forelimb; Mucuna; Oxidopamine; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotation; Time Factors; Tyrosine 3-Monooxygenase; Vibrissae | 2010 |
Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats.
Topics: Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Apomorphine; Behavior, Animal; Central Nervous System Agents; Consciousness; Croton; Disease Models, Animal; Dose-Response Relationship, Drug; Ether; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Motor Activity; Pentylenetetrazole; Plant Bark; Plant Extracts; Proanthocyanidins; Rats; Rats, Wistar; Seizures; Stereotyped Behavior | 2010 |
A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Female; Male; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Agonists; Sexual Behavior, Animal; Sexual Dysfunctions, Psychological | 2011 |
Chronic dizocilpine or apomorphine and development of neuropathy in two animal models II: effects on brain cytokines and neurotrophins.
Topics: Animals; Apomorphine; Brain; Cytokines; Disease Models, Animal; Dizocilpine Maleate; Female; Interleukin-1beta; Nerve Growth Factors; Neuralgia; Rats; Rats, Sprague-Dawley | 2011 |
Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcohol Dehydrogenase; Amphetamine; Analysis of Variance; Animals; Apomorphine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine; Odorants; Parkinson Disease; Serotonin; Smell | 2011 |
Chronic dizocilpine or apomorphine and development of neuropathy in two rat models I: behavioral effects and role of nucleus accumbens.
Topics: Animals; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Female; Mononeuropathies; Motor Activity; Neuralgia; Nucleus Accumbens; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley | 2011 |
Effects of unilateral 6-OHDA lesions on [3H]-N-propylnorapomorphine binding in striatum ex vivo and vulnerability to amphetamine-evoked dopamine release in rat.
Topics: Amphetamine; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2011 |
Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Apomorphine; Catalytic Domain; Cell Survival; Cysteine; Disease Models, Animal; Dopamine; Dopamine Agonists; Female; Gene Expression Regulation; Gliosis; Glutathione; Glutathione Reductase; Green Fluorescent Proteins; Movement; Nerve Degeneration; Rats; Rats, Wistar; RNA, Small Interfering; Sensation Disorders; Stereotyped Behavior; Substantia Nigra; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2011 |
Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Apomorphine; Brain; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytochromes; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Indoles; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Middle Aged; Motor Activity; Neurodegenerative Diseases; Neuroprostanes; Oxidopamine; Parkinson Disease; Peroxiredoxins; Postmortem Changes; RNA, Small Interfering; Signal Transduction; Thioredoxins | 2011 |
Lesions of the entopeduncular nucleus in rats prevent apomorphine-induced deficient sensorimotor gating.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Conditioning, Operant; Disease Models, Animal; Disease Progression; Dopamine Agonists; Entopeduncular Nucleus; Gait Disorders, Neurologic; Inhibition, Psychological; Male; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Reflex, Startle; Rotarod Performance Test | 2011 |
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apomorphine; Blotting, Western; Brain; Cells, Cultured; Disease Models, Animal; Dopamine Agonists; Immunohistochemistry; Insulysin; Maze Learning; Memory, Short-Term; Mice; Mice, Transgenic; Neprilysin; Neurons; Oxidative Stress; Phosphorylation; Proteasome Endopeptidase Complex; Statistics, Nonparametric; tau Proteins | 2011 |
Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion.
Topics: Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Disease Progression; Functional Laterality; Gait Disorders, Neurologic; Male; Medial Forebrain Bundle; Movement; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Rats; Rats, Wistar; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase; Videotape Recording | 2011 |
Systemic treatment of focal brain injury in the rat by human umbilical cord blood cells being at different level of neural commitment.
Topics: Analysis of Variance; Animals; Antigens, CD34; Apomorphine; Brain Injuries; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Fetal Blood; Gene Expression Regulation; Hematopoietic Stem Cell Transplantation; Humans; Infusions, Intra-Arterial; Locomotion; Male; Movement Disorders; Nerve Tissue Proteins; Neurons; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Wistar; Recognition, Psychology; Rotation; Time Factors; Vibrissae | 2011 |
Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia.
Topics: Adrenergic Agents; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopa Decarboxylase; Dopamine; Dyskinesia, Drug-Induced; Electrochemistry; Female; Functional Laterality; Levodopa; Oxidopamine; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 2011 |
Significant effects of 4-aminopyridine and tetraethylammonium in the treatment of 6-hydroxydopamine-induced Parkinson's disease.
Topics: 4-Aminopyridine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Drug Interactions; Male; Medial Forebrain Bundle; Microinjections; Oxidopamine; Parkinson Disease, Secondary; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium | 2011 |
Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arginine; Catalepsy; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavonoids; Indazoles; Male; Mice; Motor Activity; Nitric Oxide; Phytotherapy; Plant Leaves; Plant Preparations; Protein Kinase C; Psychotic Disorders; Rats; Rats, Wistar; Stereotyped Behavior; Syzygium; Tamoxifen | 2011 |
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Disease Models, Animal; Dopamine Agonists; Drug Interactions; Female; Functional Laterality; Methoxamine; Motor Activity; Motor Neurons; Movement Disorders; Quipazine; Rats; Rats, Inbred Lew; Recovery of Function; Serotonin; Serotonin Receptor Agonists; Spinal Cord Injuries; Sympatholytics; Sympathomimetics; Tyrosine 3-Monooxygenase | 2011 |
Effects of chronic, systemic treatment with the dopamine receptor agonist R-apomorphine in partially lesioned rat model of Parkinson's disease: an electrophysiological study of substantia nigra dopamine neurons.
Topics: Action Potentials; Animals; Apomorphine; Cell Count; Disease Models, Animal; Dopamine Agonists; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2011 |
Characterizing the spontaneous blink generator: an animal model.
Topics: Adult; Animals; Apomorphine; Blinking; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dry Eye Syndromes; Electric Stimulation; Electromyography; Female; Fourier Analysis; Functional Laterality; Haloperidol; Humans; Magnetics; Male; Middle Aged; Rats; Time Factors; Trigeminal Nerve; Young Adult | 2011 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; Peptide Fragments; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Rotarod Performance Test; Signal Transduction; Substance P; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation.
Topics: Amphetamines; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Dyskinesias; Female; Fetal Tissue Transplantation; Levodopa; Oxidopamine; Postoperative Complications; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Substantia Nigra; Sympatholytics | 2011 |
The involvement of RGS9 in l-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Benserazide; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RGS Proteins | 2011 |
Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcohol Dehydrogenase; Analysis of Variance; Animals; Apomorphine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrochemical Techniques; Exploratory Behavior; Female; Genotype; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Olfaction Disorders; Parkinson Disease; Smell; Time Factors | 2012 |
Effects of sertraline on experimental mouse models of psychosis.
Topics: Animals; Antidepressive Agents; Apomorphine; Catalepsy; Dextroamphetamine; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Haloperidol; Mice; Motor Activity; Psychotic Disorders; Selective Serotonin Reuptake Inhibitors; Sertraline; Time Factors | 2012 |
Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Body Weight; Corticosterone; Disease Models, Animal; Dopamine Agonists; Exploratory Behavior; Eye; Inhibition, Psychological; Psychopathology; Rats; Rats, Wistar; Reflex, Startle; Sensory Gating; Social Isolation; Stress, Psychological; Weaning | 2012 |
Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Apomorphine; Catalepsy; Disease Models, Animal; Epilepsy; Female; Haloperidol; Hypnotics and Sedatives; Isoniazid; Male; Mice; Motor Activity; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Sleep; Viscum album | 2012 |
Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy.
Topics: Animals; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Exploratory Behavior; Female; Functional Laterality; Gait Disorders, Neurologic; Motor Activity; Multiple System Atrophy; Oxidopamine; Parkinson Disease; Psychomotor Performance; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2012 |
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Area Under Curve; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Folic Acid; Homocysteine; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Stereotyped Behavior; Vitamin B Complex | 2012 |
Chronic high-frequency stimulation therapy in hemiparkinsonian rhesus monkeys using an implanted human DBS system.
Topics: Animals; Apomorphine; Cerebral Angiography; Deep Brain Stimulation; Disease Models, Animal; Electrodes, Implanted; Follow-Up Studies; Functional Laterality; Gliosis; Macaca mulatta; Male; Movement; Parkinsonian Disorders; Rotation; Subthalamic Nucleus; Time Factors | 2013 |
Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Apomorphine; Benzazepines; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Male; Morphine; Nucleus Accumbens; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Reflex, Startle; Substance Withdrawal Syndrome | 2012 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agents; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Medicine, African Traditional; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Phytotherapy; Plant Extracts; Plant Leaves; Psychotic Disorders; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Valproic Acid | 2012 |
Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Apomorphine; Apoptosis; Behavior, Animal; Benzodioxoles; Disease Models, Animal; Male; Oxidative Stress; Oxidopamine; Parkinson Disease; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2013 |
Synthesis and evaluation of a series of piperidine-2,6-dione-piperazine (piperidine) derivatives as multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Mice; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Structure-Activity Relationship | 2012 |
Survival and functional restoration of human fetal ventral mesencephalon following transplantation in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Embryo, Mammalian; Female; Graft Survival; Humans; Mesencephalon; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2013 |
New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Barbiturates; Catalepsy; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Ketamine; Male; Mice; Motor Activity; Piperazines; Psychoacoustics; Reflex, Startle; Schizophrenia; Sleep | 2013 |
Fucoidan protects against lipopolysaccharide-induced rat neuronal damage and inhibits the production of proinflammatory mediators in primary microglia.
Topics: Analysis of Variance; Animals; Apomorphine; Brain Injuries; CD11b Antigen; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Lipopolysaccharides; Male; Mental Disorders; Microglia; Neuroprotective Agents; Polysaccharides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Stereotyped Behavior; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2012 |
High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats.
Topics: Acupuncture Points; Acupuncture Therapy; Analysis of Variance; Animals; Apomorphine; Biophysical Phenomena; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Gene Expression Regulation; Male; Movement Disorders; Neurons; Neurotoxicity Syndromes; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Sympatholytics | 2013 |
Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Green Fluorescent Proteins; Male; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; Parkinsonian Disorders; POU Domain Factors; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Time Factors; Transfection; Tyrosine 3-Monooxygenase | 2013 |
Aquaporin-4 knockout abolishes apomorphine-induced tardive dyskinesia following chronic treatment with neuroleptics.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Aquaporin 4; Clozapine; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Haloperidol; Hippocampus; Male; Mastication; Mice; Mice, Knockout; Motor Activity; Movement Disorders | 2012 |
Is nicotine protective against Parkinson's disease? An experimental analysis.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Interneurons; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nicotine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Substantia Nigra | 2012 |
Neural stem cells transplanted in a mouse model of Parkinson's disease differentiate to neuronal phenotypes and reduce rotational deficit.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cell Differentiation; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; GABAergic Neurons; Graft Survival; Green Fluorescent Proteins; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oxidopamine; Parkinson Disease; Substantia Nigra; Tubulin | 2012 |
Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.
Topics: Animals; Apomorphine; Body Patterning; Brain; Disease Models, Animal; Domperidone; Dopamine; Dopamine Antagonists; Exons; Expressed Sequence Tags; F-Box Proteins; Humans; Immunohistochemistry; In Situ Hybridization; Introns; Locomotion; Neurons; Parkinsonian Disorders; Phenotype; Protein Structure, Tertiary; RNA, Messenger; Zebrafish | 2012 |
Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex.
Topics: Action Potentials; Adrenergic Agents; Afferent Pathways; Animals; Antiparkinson Agents; Apomorphine; Biophysics; Brain Mapping; Deep Brain Stimulation; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Evoked Potentials, Motor; Functional Laterality; Locomotion; Male; Medial Forebrain Bundle; Motor Cortex; Neurons; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Statistics as Topic; Subthalamic Nucleus | 2012 |
Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Apomorphine; Disease Models, Animal; Dopamine Agonists; Genes, Reporter; Glycine; HSP72 Heat-Shock Proteins; Humans; Interneurons; Mice; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neuroprotective Agents; NF-E2-Related Factor 2; Patch-Clamp Techniques; Riluzole; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Zebrafish; Zebrafish Proteins | 2013 |
Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia.
Topics: Amantadine; Amphetamine; Animals; Apomorphine; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Carbazoles; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Exercise Test; Exercise Therapy; Gene Expression Regulation; Indole Alkaloids; Male; Oxidopamine; Parkinson Disease; Putamen; Rats; Rats, Wistar; Receptor, trkB; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Forced nonuse in unilateral parkinsonian rats exacerbates injury.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Forelimb; Homovanillic Acid; Membrane Glycoproteins; Membrane Transport Proteins; Movement; Nerve Tissue Proteins; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Physical Exertion; Rats; Rats, Long-Evans; Restraint, Physical; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins | 2002 |
Ciliary neurotrophic factor overexpression in neural progenitor cells (ST14A) increases proliferation, metabolic activity, and resistance to stress during differentiation.
Topics: Animals; Apomorphine; Apoptosis; Blotting, Western; Cell Differentiation; Cell Division; Cells, Cultured; Ciliary Neurotrophic Factor; Coculture Techniques; Corpus Striatum; Culture Media, Serum-Free; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Gene Expression; In Situ Nick-End Labeling; Quinolinic Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotation; Staurosporine; Stem Cells; Stress, Physiological; Tetrazolium Salts; Thermosensing; Thymidine; Time Factors; Transfection; Tritium | 2003 |
Both short- and long-acting D-1/D-2 dopamine agonists induce less dyskinesia than L-DOPA in the MPTP-lesioned common marmoset (Callithrix jacchus).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Callithrix; Disability Evaluation; Disease Models, Animal; Dopamine Agonists; Dyskinesia, Drug-Induced; Levodopa; Motor Activity; Parkinsonian Disorders; Pergolide; Receptors, Dopamine D1; Receptors, Dopamine D2; Severity of Illness Index | 2003 |
A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation.
Topics: Animals; Apomorphine; Behavior Control; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Feeding Behavior; Female; Forelimb; Functional Laterality; Motor Skills; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Long-Evans; Recovery of Function; Substantia Nigra; Supination | 2003 |
Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Death; Disease Models, Animal; Dopamine; Female; Functional Laterality; Neostriatum; Neurons; Orientation; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Postural Balance; Posture; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2003 |
Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model.
Topics: Acupuncture Therapy; Animals; Apomorphine; Behavior, Animal; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dopamine; Immunohistochemistry; Male; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptor, trkB; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior.
Topics: Animals; Animals, Outbred Strains; Apomorphine; Benzazepines; Breeding; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Hyperkinesis; Male; Methylphenidate; Mice; Motor Activity; Raclopride; Selection, Genetic; Species Specificity; Time Factors | 2003 |
Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immobilization; Male; Medial Forebrain Bundle; Motor Activity; Nerve Growth Factors; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Rats, Sprague-Dawley | 2003 |
Deficient prepulse inhibition of acoustic startle in Hooded-Wistar rats compared with Sprague-Dawley rats.
Topics: Acoustic Stimulation; Amphetamine; Animals; Anxiety; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Schizophrenia; Species Specificity | 2003 |
EEG modifications in the cortex and striatum after dopaminergic priming in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2003 |
Convulsive and postural effects of lesioning the mid-substantia nigra pars reticulata in naïve and 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cortical Synchronization; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Kainic Acid; Motor Activity; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Posture; Rats; Rats, Sprague-Dawley; Rotation; Seizures; Substantia Nigra | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine | 2003 |
[A new vomiting animal model--mink].
Topics: Animals; Antiemetics; Apomorphine; Cisplatin; Copper Sulfate; Disease Models, Animal; Male; Metoclopramide; Mink; Ondansetron; Vomiting | 2003 |
Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression.
Topics: Animals; Antigens, Differentiation; Apomorphine; Ascorbic Acid; Astrocytes; Cell Differentiation; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Gene Expression; Gestational Age; Graft Survival; Male; Mesencephalon; Motor Activity; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Retroviridae; Stem Cell Transplantation; Stem Cells; Transcription Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2003 |
Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage.
Topics: Animals; Apomorphine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Dopamine Agonists; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Immunohistochemistry; In Situ Hybridization; Macrophages; Male; Membrane Proteins; Methamphetamine; Microglia; Mitogen-Activated Protein Kinases; Nerve Degeneration; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Riluzole, an inhibitor of glutamatergic transmission, suppresses levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Riluzole; Synaptic Transmission | 2003 |
Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study.
Topics: Afferent Pathways; Amphetamine; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Denervation; Disease Models, Animal; Dopamine; Dopamine Agonists; Extracellular Matrix; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Neostriatum; Nerve Tissue Proteins; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2003 |
Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Caudate Nucleus; Chlorides; Deferoxamine; Disease Models, Animal; Dopamine; Drug Administration Routes; Female; Ferric Compounds; Iron; Iron Chelating Agents; Parkinsonian Disorders; Putamen; Rats; Rats, Sprague-Dawley | 2003 |
Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Benzothiazoles; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazoles; Treatment Outcome; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Effect of gamma-hydroxybutyrate in two rat models of focal cerebral damage.
Topics: Animals; Apomorphine; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Kainic Acid; Learning; Male; Memory Disorders; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Sodium Oxybate | 2003 |
Dopaminergic trophism after intrastriatal injection of lentivirus-transferred GDNF in Parkinson rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Immunohistochemistry; Lentivirus; Male; Nerve Growth Factors; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2003 |
"Hydrocephalus-parkinsonism complex": progressive hydrocephalus as a factor affecting extrapyramidal tract disorder-an experimental study.
Topics: Animals; Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Behavior, Animal; Disease Models, Animal; Drug Interactions; Functional Laterality; Hydrocephalus; Kaolin; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Time Factors | 2004 |
Uptake of 6-[18F]fluoro-L-dopa and [18F]CFT reflect nigral neuronal loss in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Central Nervous System Stimulants; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine Agonists; Functional Laterality; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Propionates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 2004 |
The effects of chronic L-DOPA therapy on pharmacodynamic parameters in a rat model of motor response fluctuations.
Topics: Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Benzamides; Disease Models, Animal; Dopamine Agonists; Dyskinesias; Female; Forelimb; Immunohistochemistry; Levodopa; Medial Forebrain Bundle; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Presynaptic | 2003 |
Effects of electrolytic and 6-hydroxydopamine lesions of rat nigrostriatal pathway on nitric oxide synthase and nicotinamide adenine dinucleotide phosphate diaphorase.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Electric Injuries; Functional Laterality; Immunohistochemistry; Injections, Intraventricular; Male; Microelectrodes; NADPH Dehydrogenase; Nitric Oxide Synthase; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar | 2003 |
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
Topics: Adenoviridae; Animals; Apomorphine; Cell Death; Cell Survival; Corpus Striatum; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Infarction, Middle Cerebral Artery; Lentivirus; Male; Movement Disorders; Nerve Degeneration; Nerve Growth Factors; Rats; Rats, Wistar; Stroke; Transduction, Genetic; Treatment Failure; Up-Regulation | 2003 |
Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophrenia.
Topics: Animals; Antineoplastic Agents; Apomorphine; Brain; Cytarabine; Disease Models, Animal; Dopamine Agonists; Drug Interactions; Female; Hallucinogens; Male; Maternal-Fetal Exchange; Phencyclidine; Pregnancy; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 2004 |
Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Callithrix; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2004 |
Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Behavioral Symptoms; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Interactions; Immunohistochemistry; Male; Motor Activity; Neurons; Neuropeptides; Oxidopamine; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice.
Topics: Age Factors; Animals; Apomorphine; Autoantibodies; Autoimmunity; Behavior, Animal; Cerebrospinal Fluid; Cyclophosphamide; Disease Models, Animal; Dopamine; Dopamine Agonists; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Male; Mesencephalon; Mice; Mice, Inbred MRL lpr; Nerve Degeneration; Neurons; Tumor Necrosis Factor-alpha | 2004 |
Modifications of local cerebral glucose utilization in thalamic structures following injection of a dopaminergic agonist in the nucleus accumbens--involvement in antiepileptic effects?
Topics: Animals; Apomorphine; Autoradiography; Basal Ganglia; Deoxyglucose; Disease Models, Animal; Dopamine Agonists; Electroencephalography; Epilepsy, Absence; GABA Agonists; Glucose; Male; Microinjections; Muscimol; Nucleus Accumbens; Rats; Rats, Inbred Strains; Rats, Wistar; Thalamic Nuclei; Thalamus | 2004 |
Prepulse inhibition of acoustic startle in spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Radiation; Excitatory Amino Acid Antagonists; Hypertension; Male; Neural Inhibition; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Reflex, Acoustic; Reflex, Startle; Serotonin Receptor Agonists; Species Specificity | 2004 |
Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Therapy, Combination; Dyskinesias; Immunohistochemistry; Levodopa; Male; Oxidopamine; Parkinson Disease; Phenethylamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Effects of neonatal excitotoxic lesions of the entorhinal cortex on cognitive functions in the adult rat.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Cognition; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Entorhinal Cortex; Ibotenic Acid; Male; Maze Learning; Memory; Motivation; Motor Activity; Neurotoxins; Rats; Rats, Wistar; Reflex, Startle; Schizophrenic Psychology | 2004 |
Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding Sites; Corpus Striatum; Cyclic N-Oxides; Disease Models, Animal; Dopamine Agonists; Drug Interactions; Dyskinesia, Drug-Induced; Electron Spin Resonance Spectroscopy; Haloperidol; Humans; Male; Mastication; Motor Activity; Movement Disorders; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Dopamine D2 | 2004 |
Neuroprotective and neurotrophic effect of apomorphine in the striatal 6-OHDA-lesion rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Disease Models, Animal; Dopamine; Drug Interactions; Electrochemistry; Hydroxybenzoates; Immunohistochemistry; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Wistar; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2004 |
Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain; Brain Mapping; Cell Count; Disease Models, Animal; Dopamine; Electric Stimulation; Forelimb; Functional Laterality; Immunohistochemistry; Male; Movement; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Long-Evans; Rotation; Sympatholytics; Tyrosine 3-Monooxygenase | 2004 |
Delayed onset of prepulse inhibition deficits following kainic acid treatment on postnatal day 7 in rats.
Topics: Acoustic Stimulation; Age Factors; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Hippocampus; Inhibition, Psychological; Kainic Acid; Limbic System; Male; Maze Learning; Motor Activity; Pregnancy; Rats; Rats, Long-Evans; Reaction Time; Reflex, Startle; Schizophrenia | 2004 |
The development of various somatic markers is retarded in an animal model for schizophrenia, namely apomorphine-susceptible rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Apomorphine; Biomarkers; Disease Models, Animal; Dopamine Agonists; Female; Genotype; Handling, Psychological; Male; Phenotype; Rats; Rats, Inbred Strains; Schizophrenia; Species Specificity; Stereotyped Behavior; Stress, Psychological | 2005 |
Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Apomorphine; Catechin; Disease Models, Animal; Free Radicals; Iron; Iron Chelating Agents; Lewy Bodies; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Substantia Nigra; Synucleins; Ubiquitin | 2004 |
Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Implants; Dyskinesias; Inflammation; Injections, Subcutaneous; Macaca fascicularis; Male; Movement; Parkinsonian Disorders; Polyvinyls; Recovery of Function; Steroids | 2005 |
Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease.
Topics: Amino Acid Sequence; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Chromatography, Liquid; Corpus Striatum; Disease Models, Animal; Dynorphins; Mass Spectrometry; Microdialysis; Molecular Sequence Data; Oxidopamine; Parkinson Disease; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2005 |
Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders.
Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Apomorphine; Aspartic Acid Endopeptidases; Base Sequence; Behavior, Animal; Blotting, Northern; Blotting, Western; Disease Models, Animal; Endopeptidases; Exons; Gene Dosage; Genetic Predisposition to Disease; Genotype; Humans; Membrane Proteins; Oligonucleotide Array Sequence Analysis; Peptide Hydrolases; Phenotype; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia; Species Specificity; Stereotyped Behavior | 2005 |
Levodopa in the treatment of Parkinson's disease: current controversies.
Topics: Animals; Antiparkinson Agents; Apomorphine; Disease Models, Animal; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Haplorhini; Levodopa; Lisuride; Parkinson Disease; Pergolide | 2005 |
Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.
Topics: Animals; Apomorphine; Behavior, Animal; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Immunophilins; Male; Motor Activity; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Random Allocation; Rats; Rats, Wistar; Tacrolimus | 2005 |
Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Catecholamines; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ginkgo biloba; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Immunohistochemistry; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Plant Extracts; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Dopamine D2; Stereotyped Behavior; Substantia Nigra; Thiobarbituric Acid Reactive Substances; Tyrosine 3-Monooxygenase | 2005 |
Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Count; Cells, Cultured; Corpus Striatum; Disease Models, Animal; DNA-Binding Proteins; Dopamine and cAMP-Regulated Phosphoprotein 32; Drosophila Proteins; Endogenous Retroviruses; Functional Laterality; Galactosides; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Humans; Huntington Disease; Immunohistochemistry; Indoles; Infusions, Intravenous; Male; Motor Activity; Nerve Tissue Proteins; Neurons; Parvalbumins; Phosphoproteins; Phosphopyruvate Hydratase; Quinolinic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotarod Performance Test; Stem Cell Transplantation; Stem Cells; Time Factors | 2005 |
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
Topics: Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cell Count; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Female; Functional Laterality; Immunohistochemistry; Linear Models; Medial Forebrain Bundle; Mice; Mice, Inbred CBA; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Predictive Value of Tests; Psychomotor Performance; Rotarod Performance Test; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2005 |
Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Choice Behavior; Disease Models, Animal; Female; Grooming; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piloerection; Posture; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement, Psychology; Stereotyped Behavior; Thalamic Nuclei; Vibrissae | 2005 |
Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Count; Cell Line; Corpus Striatum; Cricetinae; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Nerve Growth Factors; Neurons; Oxidopamine; Parkinson Disease; Rats; Rotation; Simplexvirus; Substantia Nigra | 2005 |
Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain; Cell Count; Disease Models, Animal; Dopamine Agonists; Drug Interactions; Ejaculation; Exploratory Behavior; Female; Immunohistochemistry; Male; Maze Learning; Oncogene Proteins v-fos; Oxytocin; Rats; Rats, Wistar; Reaction Time; Serotonin Receptor Agonists; Sexual Behavior, Animal; Sexual Dysfunction, Physiological; Stereotyped Behavior | 2005 |
The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Electromyography; Extremities; Female; Functional Laterality; Locomotion; Muscle, Skeletal; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Inbred Lew; Stereotyped Behavior; Substantia Nigra | 2005 |
Differential expression of striatal synaptotagmin mRNA isoforms in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Brain; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Female; Gene Expression; Gene Expression Regulation; In Situ Hybridization; Levodopa; Oxidopamine; Parkinsonian Disorders; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger; Rotation; Substantia Nigra; Synaptotagmins; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apomorphine; Astrocytes; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Neurotransmitter Agents; Parkinsonian Disorders; Pinacidil; Potassium Channels, Inwardly Rectifying; Presynaptic Terminals; Propylamines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2006 |
Transplants of neurosphere cell suspensions from aged mice are functional in the mouse model of Parkinson's.
Topics: Aging; Amphetamine; Animals; Apomorphine; Astrocytes; Behavior, Animal; Behavioral Symptoms; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Functional Laterality; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofilament Proteins; Neurons; Oxidopamine; Parkinson Disease; Stem Cell Transplantation; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment.
Topics: Action Potentials; Animals; Animals, Newborn; Apomorphine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Depressants; Central Nervous System Stimulants; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrodes, Implanted; Ethanol; Female; Methylphenidate; Neurons; Pregnancy; Rats; Ventral Tegmental Area | 2006 |
Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion.
Topics: Analysis of Variance; Animals; Apomorphine; Autoradiography; Behavior, Animal; Cell Count; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; Functional Laterality; Huntington Disease; Immunohistochemistry; Male; Motor Activity; Neurons; Positron-Emission Tomography; Quinolinic Acid; Radiography; Rats; Rats, Sprague-Dawley; Recovery of Function; Rotarod Performance Test; Stem Cell Transplantation; Stem Cells | 2006 |
Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Catheter Ablation; Disease Models, Animal; Dopamine Agonists; Globus Pallidus; Macaca mulatta; Movement; Neurons; Parkinson Disease, Secondary | 2006 |
Further validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: restoration of bilateral food retrieval by dopamine receptor agonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Feeding Behavior; Functional Laterality; Homovanillic Acid; Oxidopamine; Parkinson Disease; Rats; Recovery of Function; Reproducibility of Results | 2006 |
Value of mink vomit model in study of anti-emetic drugs.
Topics: Animals; Antiemetics; Apomorphine; Cisplatin; Copper Sulfate; Disease Models, Animal; Enterochromaffin Cells; Immunohistochemistry; Male; Metoclopramide; Mink; Ondansetron; Random Allocation; Reproducibility of Results; Serotonin; Vomiting | 2006 |
Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Count; Cell Differentiation; Disease Models, Animal; Dopamine Agonists; Huntington Disease; Immunohistochemistry; Male; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Quinolinic Acid; Rats; Rats, Wistar; Stem Cell Transplantation; Time Factors; Transcription Factors; Tyrosine 3-Monooxygenase | 2006 |
Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Cell Count; Cell Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Female; Glial Cell Line-Derived Neurotrophic Factor; Green Fluorescent Proteins; Motor Activity; Neurons; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Recovery of Function; Rotarod Performance Test; Transplants; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2006 |
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats.
Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Gait Disorders, Neurologic; Imidazoles; Isoxazoles; Male; Neural Inhibition; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle | 2006 |
Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat.
Topics: Animals; Antiporters; Apomorphine; Bacterial Proteins; Behavior, Animal; Cell Transplantation; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Doxycycline; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotarod Performance Test; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Neuroprotective effects of caffeine in the model of 6-hydroxydopamine lesion in rats.
Topics: Animals; Apomorphine; Brain; Brain Diseases; Caffeine; Disease Models, Animal; Dopamine Agents; Male; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar | 2006 |
Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Biomechanical Phenomena; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Immunohistochemistry; Male; Movement; Oxidopamine; Parkinson Disease; Posture; Psychomotor Performance; Rats; Rats, Long-Evans; Rotarod Performance Test; Sex Characteristics; Sex Factors; Tyrosine 3-Monooxygenase | 2006 |
Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.
Topics: alpha-Synuclein; Amphetamine; Animals; Apomorphine; Behavior, Animal; Benserazide; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Genetic Predisposition to Disease; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parkinson Disease; Stereotypic Movement Disorder | 2006 |
Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Callithrix; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Grooming; Hallucinations; Levodopa; Parkinsonian Disorders; Psychomotor Agitation; Psychotic Disorders; Statistics, Nonparametric; Stereotyped Behavior | 2006 |
Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Cell Count; Cell Line; Disease Models, Animal; Dopamine; Male; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Neurturin; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Tyrosine 3-Monooxygenase | 2007 |
Differences in the cellular mechanism underlying the effects of amphetamine on prepulse inhibition in apomorphine-susceptible and apomorphine-unsusceptible rats.
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Apomorphine; Brain; Central Nervous System Stimulants; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inhibition, Psychological; Injections, Intraperitoneal; Male; Neurons; Rats; Rats, Inbred Strains; Reflex, Startle; Remoxipride; Reserpine; Schizophrenic Psychology | 2007 |
Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Functional Laterality; Levodopa; Male; Multiple System Atrophy; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Substantia Nigra | 2007 |
Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Dopamine; Female; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; In Situ Hybridization; Motor Activity; Neurturin; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Stromal Cells; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Effects of engrafted neural stem cells derived from GFP transgenic mice in Parkinson's diseases rats.
Topics: Animals; Animals, Newborn; Antiparkinson Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Mice; Mice, Transgenic; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Stereotyped Behavior; Sympatholytics; Time Factors; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2007 |
Effects of apomorphine on the expression of learned helplessness behavior.
Topics: Adaptation, Psychological; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Depression; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Helplessness, Learned; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 2007 |
Experimental change on dopaminergic neurons in striatum of Parkinson disease rats.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Male; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Stereotypic Movement Disorder; Substantia Nigra; Up-Regulation | 2007 |
Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus.
Topics: Animals; Apomorphine; Disease Models, Animal; Dopamine; Gerbillinae; Hippocampus; Humans; Microscopy, Electron, Scanning; Nerve Degeneration; Neurons; Schizophrenia | 2007 |
Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism.
Topics: Absorbable Implants; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Delivery Systems; Drug Interactions; Functional Laterality; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2007 |
Identification of genetic and epigenetic variations in a rat model for neurodevelopmental disorders.
Topics: Animals; Apomorphine; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 9; Disease Models, Animal; DNA Primers; Gene Rearrangement; Genetic Predisposition to Disease; Genetic Variation; Humans; Membrane Proteins; Mental Disorders; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Rats; Rats, Wistar; Schizophrenia | 2007 |
Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.
Topics: Age Factors; Animals; Apomorphine; Appetite Regulation; Autoradiography; Brain; Disease Models, Animal; Dopamine; Dopamine Agonists; Eating; Food Deprivation; In Vitro Techniques; Male; Motor Activity; Obesity; Positron-Emission Tomography; Raclopride; Rats; Rats, Zucker; Receptors, Dopamine D2; Receptors, Leptin; Spiperone; Tritium | 2008 |
Low doses of apomorphine transiently reduce locomotor activity in MPTP-treated mice.
Topics: Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neural Inhibition; Parkinsonian Disorders | 2007 |
Effects of chronic renal failure on the expression of connexin 43 in the rat's corpus cavernosum.
Topics: Animals; Apomorphine; Blotting, Western; Connexin 43; Disease Models, Animal; Erectile Dysfunction; Gene Expression; Kidney Failure, Chronic; Male; Penile Erection; Penis; Rats; Rats, Sprague-Dawley | 2008 |
Generation of a alpha-synuclein-based rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; alpha-Synuclein; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Gene Expression Regulation; Gene Products, tat; Genetic Vectors; Green Fluorescent Proteins; Male; Motor Activity; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2008 |
Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission.
Topics: Analysis of Variance; Animals; Apomorphine; Brain Damage, Chronic; Disease Models, Animal; Dopamine; Dopamine Agonists; Functional Laterality; Locomotion; Male; Motor Activity; MPTP Poisoning; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Rotation; Severity of Illness Index; Statistics, Nonparametric; Substantia Nigra | 2008 |
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
Topics: Amphetamine; Animals; Antioxidants; Apomorphine; Behavior, Animal; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Wistar; Substantia Nigra; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase | 2008 |
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang.
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Feeding Behavior; Fenclonine; Flavonoids; Humans; Hypothermia; Male; Mice; Mice, Inbred ICR; Motor Activity; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Physiological; Yohimbine | 2008 |
Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results.
Topics: Animals; Apomorphine; Autopsy; Behavior, Animal; Brain; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lithium Compounds; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phenotype; Reflex, Startle; Schizophrenia; Stereotyped Behavior; Swimming | 2008 |
[Establishment of a rat model of diabetic erectile dysfunction].
Topics: Animals; Apomorphine; Diabetes Mellitus, Experimental; Disease Models, Animal; Erectile Dysfunction; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin | 2008 |
Oral dyskinesia in brain-damaged rats withdrawn from a neuroleptic: implication for models of tardive dyskinesia.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain; Chlorpromazine; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Mouth Diseases; Movement Disorders; Occipital Lobe; Rats; Substance Withdrawal Syndrome | 1980 |
[Effect of psychotropic drugs on the central dopamine metabolism (example: neuroleptics)].
Topics: Adenylyl Cyclases; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Brain; Catalepsy; Cats; Conditioning, Classical; Disease Models, Animal; Dogs; Dopamine; Dopamine Antagonists; Humans; In Vitro Techniques; Rats; Receptors, Dopamine; Vomiting | 1981 |
[Hypersensitivity to apomorphine in rats treated with neuroleptics: a model of tardive dyskinesia].
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Drug Hypersensitivity; Drug Interactions; Dyskinesia, Drug-Induced; Female; Rats; Rats, Inbred Strains | 1982 |
Animal models of tardive dyskinesias.
Topics: Animals; Antipsychotic Agents; Apomorphine; Chlorpromazine; Disease Models, Animal; Dyskinesia, Drug-Induced; Epidemiologic Methods; Guinea Pigs; Haloperidol; Humans; Time Factors | 1983 |
Behavioural and biochemical alterations following haloperidol treatment and withdrawal: the animal model of tardive dyskinesia reexamined.
Topics: Animals; Apomorphine; Behavior, Animal; Brain; Disease Models, Animal; Dopamine; Glutamate Decarboxylase; Haloperidol; Humans; Male; Motor Activity; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase | 1983 |
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs; Haloperidol; Humans; Indoles; Male; Molindone; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1984 |
N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects locomotor activity without producing a nigrostriatal lesion in the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Apomorphine; Corpus Striatum; Depression, Chemical; Disease Models, Animal; Male; Motor Activity; Neural Pathways; Parkinson Disease; Pyridines; Rats; Rats, Inbred Strains; Substantia Nigra | 1984 |
Dopamine inhibitory and excitatory systems in tardive dyskinesias.
Topics: Animals; Apomorphine; Disease Models, Animal; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Hydroxydopamines; Male; Nucleus Accumbens; Oxidopamine; Piribedil; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride | 1983 |
Characterization of the rat mutant dystonic (dt): a new animal model of dystonia musculorum deformans.
Topics: Aging; Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Dopamine; Dystonia Musculorum Deformans; Haloperidol; Motor Activity; Mutation; Norepinephrine; Pedigree; Rats; Rats, Mutant Strains | 1984 |
Oral tardive dyskinesia in the rat.
Topics: Animals; Apomorphine; Bruxism; Dental Occlusion, Traumatic; Disease Models, Animal; Dyskinesia, Drug-Induced; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Time Factors | 1983 |
LSD-potentiated apomorphine hypermotility: a model for differentiating antipsychotic drugs.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Disease Models, Animal; Drug Antagonism; Haloperidol; Humans; Hyperkinesis; Lysergic Acid Diethylamide; Male; Motor Activity; Rats; Rats, Inbred Strains; Sulpiride | 1983 |
An evaluation of the young dopamine-lesioned rat as an animal model for minimal brain dysfunction (MBD).
Topics: Animals; Apomorphine; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Dopamine; Female; Humans; Hydroxydopamines; Male; Motor Activity; Rats; Time Factors | 1980 |
Effects of d-amphetamine and apomorphine in a new animal model of petit mal epilepsy.
Topics: Animals; Apomorphine; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Absence; Habituation, Psychophysiologic; Male; Phenoxybenzamine; Photic Stimulation; Pimozide; Rats | 1980 |
Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone.
Topics: Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Humans; Male; Methadone; Motor Activity; Naloxone; Phencyclidine; Psychoses, Substance-Induced; Rats; Rats, Inbred Strains; Stereotyped Behavior; Time Factors | 1981 |
MK-771 antagonizes the enhanced response to apomorphine in rats treated chronically with haloperidol - implications for tardive dyskinesia.
Topics: Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Thiazolidines; Thyrotropin-Releasing Hormone | 1982 |
A new animal model for Tourette syndrome.
Topics: Animals; Apomorphine; Dextroamphetamine; Disease Models, Animal; Haloperidol; Humans; Male; Nitriles; Rats; Rats, Inbred Strains; Rodent Diseases; Stereotyped Behavior; Tourette Syndrome | 1982 |
Hormonal interference in experimental models of depression.
Topics: Animals; Apomorphine; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Haloperidol; Humans; Motor Activity; Muscle Tonus; Prolactin; Receptors, Dopamine | 1982 |
A mechanographic method for measurement of muscle tone in the conscious rat. The calf muscle stretch response in reserpine-induced rigidity.
Topics: Animals; Apomorphine; Biomechanical Phenomena; Disease Models, Animal; Haloperidol; Male; Muscle Contraction; Muscle Rigidity; Muscle Tonus; Neurophysiology; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Reflex, Stretch; Reserpine | 1982 |
[Hallucinogen caused motility disorders in rats as potential psychosis relevant animal model].
Topics: Animals; Apomorphine; Brain; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Hallucinogens; Humans; Lysergic Acid Diethylamide; Methysergide; Motor Activity; Psychoses, Substance-Induced; Rats; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 1982 |
Correlation between daily dosage of chlorpromazine and subsequent supersensitivity.
Topics: Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Membranes; Stereotyped Behavior | 1980 |
Antagonism of dopamine supersensitivity by estrogen: neurochemical studies in an animal model of tardive dyskinesia.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Estradiol; Female; Haloperidol; Humans; Rats; Receptors, Dopamine; Stereotyped Behavior; Substance Withdrawal Syndrome | 1981 |
The behavior of APO-SUS rats in animal models with construct validity for schizophrenia.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Exploratory Behavior; Male; Mastication; Neural Inhibition; Rats; Rats, Wistar; Reaction Time; Reflex, Startle; Schizophrenic Psychology; Stereotyped Behavior; Taste | 1995 |
Behavioral involvement of central dopamine D1 and D2 receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Macaca fascicularis; Parkinson Disease, Secondary; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride; Time Factors | 1995 |
Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mazindol; Neural Pathways; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 1995 |
Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Forelimb; Parkinson Disease; Rats; Rats, Inbred Strains; Rotation | 1995 |
Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphine; Brain Tissue Transplantation; Carbidopa; Dextroamphetamine; Disease Models, Animal; Dopamine; Dopamine Agonists; Ergolines; Female; Fetal Tissue Transplantation; Forelimb; Functional Laterality; Levodopa; Motor Activity; Movement Disorders; Norepinephrine; Oxidopamine; Parkinson Disease; Quinpirole; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Transplantation, Heterotopic | 1995 |
Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Functional Laterality; Huntington Disease; Male; Motor Activity; Neurotoxins; Nitro Compounds; Propionates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Dose- and duration-dependent tolerance to rotational effects of apomorphine in a rat model of Parkinsonism.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Tolerance; Dyskinesia, Drug-Induced; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley | 1995 |
Nerve growth factor released by transgenic astrocytes enhances the function of adrenal chromaffin cell grafts in a rat model of Parkinson's disease.
Topics: Adrenal Medulla; Animals; Animals, Genetically Modified; Apomorphine; Astrocytes; Cells, Cultured; Disease Models, Animal; Male; Motor Activity; Neostriatum; Nerve Growth Factors; Parkinson Disease; Rats; Recombinant Proteins; Rotation; Transplantation, Heterotopic | 1994 |
Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora.
Topics: Adrenal Glands; Animals; Antigens, Bacterial; Apomorphine; Arthritis, Experimental; Bacteria; Corticosterone; Disease Models, Animal; Female; Germ-Free Life; Hypothalamo-Hypophyseal System; Interleukin-1; Neuroimmunomodulation; Pituitary-Adrenal System; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Wistar; Species Specificity | 1994 |
The role of D1 and D2 receptors in the heightened locomotion induced by direct and indirect dopamine agonists in rats with hippocampal damage: an animal analogue of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Arousal; Brain Mapping; Dextroamphetamine; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Hippocampus; Male; Motor Activity; Quinpirole; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Stereotyped Behavior | 1993 |
Effect of chronic antidepressant treatment on responses to apomorphine in selectively bred rat strains.
Topics: 1-Naphthylamine; Animals; Apomorphine; Body Temperature Regulation; Breeding; Depressive Disorder; Desipramine; Disease Models, Animal; Male; Motor Activity; Parasympathetic Nervous System; Rats; Sertraline; Time Factors | 1993 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Synergism; Glucose; Inositol; Lithium; Male; Motor Activity; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior | 1993 |
Classification of drug-induced behaviors using a multi-layer feed-forward neural network.
Topics: Animals; Apomorphine; Behavior, Animal; Bias; Central Nervous System; Disease Models, Animal; Evaluation Studies as Topic; Fourier Analysis; Grooming; Male; Microcomputers; Monitoring, Physiologic; Motor Activity; Neural Networks, Computer; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Processing, Computer-Assisted; Smell; Tongue; Videotape Recording | 1993 |
Electrical sensitization of the meso-limbic dopaminergic system in rats: a pathogenetic model for schizophrenia.
Topics: Amphetamine; Animals; Apomorphine; Benzazepines; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Electric Stimulation; Electroencephalography; Habituation, Psychophysiologic; Haloperidol; Limbic System; Male; Models, Neurological; Motor Activity; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D1; Salicylamides; Schizophrenia; Seizures; Stereotyped Behavior; Tegmentum Mesencephali; Time Factors | 1993 |
Pica in rats is analogous to emesis: an animal model in emesis research.
Topics: Animals; Antiemetics; Apomorphine; Cisplatin; Copper; Copper Sulfate; Disease Models, Animal; Domperidone; Dose-Response Relationship, Drug; Food; Kaolin; Male; Ondansetron; Pica; Rats; Rats, Wistar; Vomiting | 1993 |
Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia.
Topics: Animals; Apomorphine; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology | 1993 |
Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Genetic Vectors; Humans; Male; Nerve Fibers; Nerve Growth Factors; Nerve Tissue Proteins; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Retroviridae; Rotation; Transduction, Genetic | 1995 |
The effect of transcranial magnetic stimulation of rat brain on behavioral models of depression.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Electric Stimulation; Electroconvulsive Therapy; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Transcranial Magnetic Stimulation | 1995 |
Selective adenosine A2A receptor/dopamine D2 receptor interactions in animal models of schizophrenia.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Schizophrenia | 1996 |
Transplantation of human fetal striatum into a rodent model of Huntington's disease ameliorates locomotor deficits.
Topics: Acetylcholinesterase; Animals; Antiparkinson Agents; Apomorphine; Brain Tissue Transplantation; Coloring Agents; Disease Models, Animal; Fetal Tissue Transplantation; Histocytochemistry; Humans; Huntington Disease; Locomotion; Male; NADPH Dehydrogenase; Neostriatum; Phenothiazines; Rats; Rats, Sprague-Dawley; Rotation | 1996 |
Somatic delivery of catecholamines in the striatum attenuate parkinsonian symptoms and widen the therapeutic window of oral sinemet in rats.
Topics: Administration, Oral; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Carbidopa; Cell Transplantation; Disease Models, Animal; Dopamine; Drug Combinations; Drug Synergism; Levodopa; Male; Movement Disorders; Neostriatum; Parkinson Disease, Secondary; PC12 Cells; Rats; Rats, Sprague-Dawley; Rotation | 1997 |
The effect of nigral implantation on sensitization to dopamine agonists in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Locomotion; Male; Oxidopamine; Pregnancy; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Prefrontal cortical and hippocampal modulation of dopamine-mediated effects.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Disease Models, Animal; Dopamine; Haloperidol; Hippocampus; Humans; Motor Activity; Prefrontal Cortex; Rats; Reflex, Startle; Schizophrenia; Sexual Maturation; Stereotyped Behavior; Stress, Psychological; Synapses; Synaptic Transmission | 1998 |
An animal model of copulatory disorder induced by social stress in male mice: effects of apomorphine and L-dopa.
Topics: Aggression; Animals; Apomorphine; Copulation; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Levodopa; Male; Mice; Mice, Inbred ICR; Sexual Behavior, Animal; Sexual Dysfunction, Physiological; Social Environment; Stress, Psychological | 1997 |
An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism.
Topics: Animals; Apomorphine; Automation; Brain; Disease Models, Animal; Equipment Design; Female; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reference Values; Reproducibility of Results | 1997 |
Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenoviridae; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Enzyme-Linked Immunosorbent Assay; Female; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Nerve Regeneration; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics | 1997 |
Fixed-ratio discrimination training as replacement therapy in Parkinson's disease: studies in a 6-hydroxydopamine-treated rat model.
Topics: Amphetamine; Animals; Apomorphine; Conditioning, Operant; Corpus Striatum; Discrimination Learning; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Motor Activity; Neurotoxins; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1998 |
Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch-Nyhan syndrome.
Topics: Animals; Animals, Newborn; Apomorphine; Catecholamines; Disease Models, Animal; Dopamine Agonists; Electroshock; Injections, Intraventricular; Lesch-Nyhan Syndrome; Male; Neostriatum; Neurotoxins; Oxidopamine; Rats; Rats, Sprague-Dawley; Self-Injurious Behavior; Stress, Physiological | 1998 |
Topographical organization of opioid peptide precursor gene expression following repeated apomorphine treatment in the 6-hydroxydopamine-lesioned rat.
Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Disease Models, Animal; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Male; Motor Activity; Nucleus Accumbens; Organ Specificity; Oxidopamine; Parkinson Disease; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 1998 |
Asymmetry of sympathetic activity in a rat model of Parkinson's disease induced by 6-hydroxydopamine: haemodynamic, electrocardiographic and biochemical changes.
Topics: Animals; Apomorphine; Behavior, Animal; Catecholamines; Disease Models, Animal; Electrocardiography; Functional Laterality; Hemodynamics; Immunohistochemistry; Male; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 1998 |
Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Levodopa; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Fibers; Nerve Tissue Proteins; Neuropeptides; Neurotransmitter Agents; Oxidopamine; Parkinson Disease, Secondary; Prosencephalon; Radioimmunoassay; Rats; Rats, Wistar; Substantia Nigra; Sulpiride; Sympatholytics; Tyrosine 3-Monooxygenase; Ventral Tegmental Area; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dependovirus; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; GTP Cyclohydrolase; Humans; Levodopa; Male; Microdialysis; Neurons; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Recombinant Proteins; Rotation; Tyrosine 3-Monooxygenase | 1998 |
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
Topics: 3T3 Cells; Animals; Antioxidants; Antiparkinson Agents; Apomorphine; Behavior, Animal; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Therapy; Gliosarcoma; GTP Cyclohydrolase; Humans; Levodopa; Male; Mice; Microdialysis; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Retroviridae; Transformation, Genetic; Transgenes; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1998 |
Effects of dopaminergic drugs, occlusal disharmonies, and chronic stress on non-functional masticatory activity in the rat, assessed by incisal attrition.
Topics: Analysis of Variance; Animals; Apomorphine; Bruxism; Cocaine; Dental Occlusion, Traumatic; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Haloperidol; Incisor; Male; Masticatory Muscles; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Stress, Physiological; Tooth Attrition | 1998 |
The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Parkinson Disease, Secondary; Tyrosine 3-Monooxygenase | 1998 |
Excitotoxic lesions of the rat medial prefrontal cortex. Effects on abnormal behaviors associated with neonatal hippocampal damage.
Topics: Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; Hippocampus; In Situ Hybridization; Motor Activity; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stereotyped Behavior | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Embryonic striatal grafts restore neuronal activity of the globus pallidus in a rodent model of Huntington's disease.
Topics: Action Potentials; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Electron Transport Complex IV; Electrophysiology; Fetal Tissue Transplantation; Globus Pallidus; Huntington Disease; Male; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rotation | 1999 |
Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions.
Topics: Adaptation, Physiological; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Female; Forelimb; Gait; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics; Tyrosine 3-Monooxygenase | 1999 |
Disruption of latent inhibition in rats with postnatal hippocampal lesions.
Topics: Anesthesia; Animals; Apomorphine; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Agonists; Hippocampus; Ibotenic Acid; Learning; Motor Activity; Neural Inhibition; Rats; Rats, Sprague-Dawley; Schizophrenic Psychology | 1999 |
Apomorphine protects against MPTP-induced neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Tyrosine 3-Monooxygenase | 1999 |
Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.
Topics: Adenoviridae; Animals; Anti-Bacterial Agents; Antiparkinson Agents; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Doxycycline; Female; Gene Expression Regulation; Gene Transfer Techniques; Humans; Immunohistochemistry; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine 3-Monooxygenase | 1999 |
A new video/computer method to measure the amount of overall movement in experimental animals (two-dimensional object-difference method).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Callithrix; Computer Storage Devices; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Image Interpretation, Computer-Assisted; Movement; Parkinson Disease; Time Factors; Video Recording | 1999 |
The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew).
Topics: Analysis of Variance; Animals; Apomorphine; Benzopyrans; Brain Chemistry; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Indans; Male; Oxazines; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Shrews; Species Specificity; Sulpiride; Tetrahydronaphthalenes; Vomiting | 1999 |
Effects of chronic haloperidol and clozapine on vacuous chewing and dopamine-mediated jaw movements in rats: evaluation of a revised animal model of tardive dyskinesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dyskinesia, Drug-Induced; Haloperidol; Jaw; Male; Mastication; Quinpirole; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Serotonin Antagonists | 1999 |
Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Rotation; Substantia Nigra; Sympatholytics | 2000 |
Who believes in "communication"? The Norman Cousins Lecture, 1999.
Topics: Adaptation, Psychological; Aggression; Animals; Apomorphine; Arthritis, Rheumatoid; Autoimmune Diseases; Behavior; Behavior, Animal; beta-Adrenergic Receptor Kinases; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Disease Susceptibility; Encephalomyelitis, Autoimmune, Experimental; Humans; Hypothalamo-Hypophyseal System; Inflammation; Motor Activity; Multiple Sclerosis; Neuroimmunomodulation; Neurosecretory Systems; Pituitary-Adrenal System; Psychoneuroimmunology; Psychotherapy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta-2; Schizophrenia; Stress, Physiological; Th1 Cells; Th2 Cells; Trichinellosis | 2000 |
The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages.
Topics: Animals; Apomorphine; Axons; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Functional Laterality; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Movement; Neostriatum; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase; Weight Loss | 2000 |
Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats.
Topics: Adenoviridae; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Cell Count; Corpus Striatum; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Phenotype; Rats; Rats, Inbred F344; Recovery of Function; Treatment Outcome; Tyrosine 3-Monooxygenase | 2000 |
Effects of oligonucleotide antisense to dopamine D(1A) receptor messenger RNA in a rodent model of levodopa-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Cocaine; Denervation; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Gene Expression; Levodopa; Male; Oligonucleotides, Antisense; Oxidopamine; Phenotype; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Rotation; Substantia Nigra; Sympatholytics; Tritium | 2000 |
The antidepressive-like effect of oxcarbazepine: possible role of dopaminergic neurotransmission.
Topics: Animals; Antidepressive Agents; Apomorphine; Carbamazepine; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Haloperidol; Male; Neurotransmitter Agents; Oxcarbazepine; Rats; Rats, Wistar; Receptors, Dopamine; Stereotypic Movement Disorder; Swimming | 2000 |
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy).
Topics: Animals; Apomorphine; Autoradiography; Binding, Competitive; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Fetal Tissue Transplantation; Male; Membrane Proteins; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Oxidopamine; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Striatonigral Degeneration; Treatment Failure | 2000 |
Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Antiparkinson Agents; Apomorphine; Capsules; Cattle; Chromaffin Cells; Disease Models, Animal; Dopamine; Female; Homovanillic Acid; Macaca mulatta; Microdialysis; Neostriatum; Parkinsonian Disorders; Stereotyped Behavior; Transplantation, Heterologous | 2000 |
Birth insult alters dopamine-mediated behavior in a precocial species, the guinea pig. Implications for schizophrenia.
Topics: Age Factors; Amphetamine; Animals; Apomorphine; Asphyxia Neonatorum; Behavior, Animal; Cesarean Section; Disease Models, Animal; Dopamine; Female; Guinea Pigs; Humans; Hypoxia, Brain; Infant, Newborn; Male; Motor Activity; Neural Inhibition; Reflex, Startle; Schizophrenia | 2000 |
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity.
Topics: Adenosine Triphosphatases; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Male; Melatonin; Mitochondria; Motor Activity; NAD; Neuroprotective Agents; Oxidative Phosphorylation; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2001 |
IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands.
Topics: Abortion, Induced; Animals; Apomorphine; Brain; Brain Tissue Transplantation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopamine; Female; Fetal Tissue Transplantation; Fibroblast Growth Factor 2; Homovanillic Acid; Humans; Insulin-Like Growth Factor I; Male; Methamphetamine; Motor Activity; Neurons; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Rats, Sprague-Dawley; Rotation; Transplantation, Heterologous; Tyrosine 3-Monooxygenase | 2001 |
Hyperactivity and impaired response habituation in hyperdopaminergic mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Apomorphine; Attention Deficit Disorder with Hyperactivity; Benzazepines; Carrier Proteins; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Female; Homovanillic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Nerve Tissue Proteins; Psychomotor Agitation; Quinpirole; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2001 |
Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence.
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Axonal Transport; Corpus Striatum; Disease Models, Animal; Male; Motor Activity; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Vitamin E; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2001 |
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy).
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Fetal Tissue Transplantation; Humans; Male; Mesencephalon; Motor Activity; Multiple System Atrophy; Neurons; Neurotoxins; Nitro Compounds; Propionates; Psychomotor Performance; Rats; Rats, Wistar; Substantia Nigra; Time Factors | 2001 |
Microencapsulated bovine chromaffin cell xenografts into hemiparkinsonian rats: a drug-induced rotational behavior and histological changes analysis.
Topics: Animals; Apomorphine; Capsules; Cattle; Cell Survival; Chromaffin Cells; Disease Models, Animal; Female; Microscopy, Fluorescence; Parkinson Disease; Parkinson Disease, Secondary; Psychomotor Disorders; Rats; Rats, Sprague-Dawley; Rotation; Sensitivity and Specificity; Transplantation, Heterologous | 2001 |
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Neurotransmitter Agents; Psychotic Disorders; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 2000 |
Attenuation of paraquat-induced dopaminergic toxicity on the substantia nigra by (-)-deprenyl in vivo.
Topics: Animals; Apomorphine; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Herbicides; Male; Neuroprotective Agents; Paraquat; Rats; Rats, Wistar; Selegiline; Stereotyped Behavior; Substantia Nigra | 2001 |
Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Binding, Competitive; Catecholamines; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Glutathione; Glutathione Disulfide; Immunohistochemistry; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Stereoisomerism; Substantia Nigra; Tyrosine 3-Monooxygenase | 2001 |
Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Cell Differentiation; Cell Line, Transformed; Disease Models, Animal; Dopamine Agents; Epithelial Cells; Graft Survival; Infarction, Middle Cerebral Artery; Male; Maze Learning; Mice; Motor Activity; Neurons; Rats; Rats, Wistar; Reaction Time; Recovery of Function; Stem Cell Transplantation; Stem Cells; Stroke; Temperature; Treatment Outcome | 2001 |
Entopeduncular lesions facilitate and thalamic lesions depress spontaneous and drug-evoked motor behavior in the hemiparkinsonian rat.
Topics: Amphetamine; Animals; Apomorphine; Denervation; Disease Models, Animal; Dopamine Agonists; Dyskinesia, Drug-Induced; Entopeduncular Nucleus; Male; Motor Cortex; Neural Inhibition; Neural Pathways; Neurosurgical Procedures; Oxidopamine; Parkinsonian Disorders; Rats; Thalamus; Ventral Thalamic Nuclei | 2001 |
The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.
Topics: Adrenergic Agents; Animals; Anxiety; Apomorphine; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus, Middle; Male; Memantine; Microinjections; Neurotransmitter Agents; Phenylephrine; Picrotoxin; Rats; Serotonin; Sulpiride; Yohimbine | 2001 |
Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Behavior, Animal; Body Temperature; Casts, Surgical; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Homovanillic Acid; Immobilization; Male; Medial Forebrain Bundle; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Neural Pathways; Neurons; Neuropeptides; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Long-Evans; Substantia Nigra; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Electromyography; Female; Genes, Recessive; Immunohistochemistry; Indoles; Levodopa; Male; Memory Disorders; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; Motor Activity; Neurons; Parkinson Disease, Secondary; Postural Balance; Selegiline; Tyrosine 3-Monooxygenase | 2001 |
Electrophysiological and pharmacological characteristics of two types of spike-wave discharges in WAG/Rij rats.
Topics: Action Potentials; Animals; Apomorphine; Biological Clocks; Cerebral Cortex; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Electroencephalography; Epilepsy, Absence; Haloperidol; Neurons; Rats; Rats, Mutant Strains | 2001 |
In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions.
Topics: Action Potentials; Anesthesia; Animals; Apomorphine; Chloral Hydrate; Corpus Striatum; Disease Models, Animal; Dopamine; Electrodes, Implanted; Male; Microelectrodes; Motor Activity; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Wakefulness | 2001 |
Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats.
Topics: Animals; Apomorphine; Aromatic-L-Amino-Acid Decarboxylases; Dependovirus; Disease Models, Animal; Dopamine; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Levodopa; Neostriatum; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotation; Transduction, Genetic | 2001 |
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glial Cell Line-Derived Neurotrophic Factor; Hedgehog Proteins; Humans; Microinjections; Motor Activity; Myristic Acid; Nerve Growth Factors; Nerve Tissue Proteins; Organ Specificity; Oxidopamine; Parkinson Disease, Secondary; Peptide Fragments; Rats; Trans-Activators; Tyrosine 3-Monooxygenase | 2002 |
Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Cabergoline; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Drug Antagonism; Ergolines; Levodopa; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Synaptic Transmission | 2002 |
Striatal AMPA receptor binding is unaltered in the MPTP-lesioned macaque model of Parkinson's disease and dyskinesia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alanine; Animals; Apomorphine; Autoradiography; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Agonists; Female; Ligands; Macaca mulatta; Male; Organ Specificity; Parkinson Disease, Secondary; Pyrimidines; Radioligand Assay; Receptors, AMPA | 2002 |
The rate of intravenous cocaine administration determines susceptibility to sensitization.
Topics: Animals; Apomorphine; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intravenous; Male; Medial Forebrain Bundle; Microinjections; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Development of a rat model of sexual performance anxiety: effect of behavioural and pharmacological hyperadrenergic stimulation on APO-induced erections.
Topics: Animals; Anxiety Disorders; Apomorphine; Blood Pressure; Disease Models, Animal; Erectile Dysfunction; Heart Rate; Hemodynamics; Male; Methoxamine; Penile Erection; Rats; Rats, Wistar; Sexual Behavior, Animal; Stress, Psychological; Sympathetic Nervous System | 2002 |
Somatostatin modulates the behavioral effects of dopamine receptor activation in parkinsonian rats.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Administration Routes; Male; Medial Forebrain Bundle; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Somatostatin | 2002 |
Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Line; Corpus Striatum; Dependovirus; Disease Models, Animal; Dopamine; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Medial Forebrain Bundle; Motor Activity; Nerve Growth Factors; Oxidopamine; Parkinsonian Disorders; Phenotype; Rats; Rats, Inbred F344; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea.
Topics: Animals; Apomorphine; Behavior; Choline O-Acetyltransferase; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Glutamate Decarboxylase; Humans; Huntington Disease; Kainic Acid; Male; Nucleus Accumbens; Pyrrolidines; Rats; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1978 |
Kainic acid lesions of the striatum: behavioural sequalae similar to Huntington's chorea.
Topics: Animals; Apomorphine; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Habituation, Psychophysiologic; Humans; Huntington Disease; Kainic Acid; Male; Motor Activity; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1978 |
Differential enhancement of locomotor activity by dopamine agonists following chronic neuroleptic treatment: an animal model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Ergolines; Male; Motor Activity; Rats; Time Factors | 1979 |
Experimental torticollis in the monkey produced by unilateral 6-hydroxy-dopamine brain lesions.
Topics: Animals; Apomorphine; Callitrichinae; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Dominance, Cerebral; Dose-Response Relationship, Drug; Haplorhini; Humans; Hydroxydopamines; Hypothalamus; Male; Movement; Receptors, Dopamine; Stereotyped Behavior; Tegmentum Mesencephali; Torticollis | 1978 |
Experimental torticollis in the marmoset produced by injection of 6-hydroxydopamine into the ascending nigrostriatal pathway.
Topics: Amphetamine; Animals; Apomorphine; Benserazide; Callitrichinae; Disease Models, Animal; Drug Therapy, Combination; Haloperidol; Haplorhini; Hydroxydopamines; Hypothalamus; Levodopa; Locus Coeruleus; Male; Torticollis | 1979 |
Sedative effects of apomorphine in an animal model of Huntington's disease.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Humans; Huntington Disease; Kainic Acid; Male; Motor Activity; Rats; Receptors, Dopamine; Stereotyped Behavior | 1979 |
Acute dystonia as an idiosyncratic response to neuroleptics in baboons.
Topics: 5-Hydroxytryptophan; Acute Disease; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Haloperidol; Haplorhini; Humans; Levodopa; Movement Disorders; Papio; Parasympatholytics; Physostigmine; Pimozide; Receptors, Dopamine; Reserpine; Syndrome; Tranquilizing Agents | 1977 |
Clinical and experimental studies of phenytoin-induced hyperkinesias.
Topics: Aged; Animals; Apomorphine; Basal Ganglia; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Drug Synergism; Dyskinesia, Drug-Induced; Female; Guinea Pigs; Haloperidol; Humans; Hyperkinesis; Male; Middle Aged; Phenytoin; Stereotyped Behavior | 1979 |
A dopaminergic basis for the effects of amphetamine on a mouse "preadolescent hyperkinetic" model.
Topics: Adolescent; Aging; Amphetamine; Animals; Apomorphine; Clonidine; Disease Models, Animal; Humans; Hyperkinesis; Mice; Mice, Inbred Strains; Myoclonus; Sleep | 1977 |
Choline chloride in animal models of tardive dyskinesia.
Topics: Animals; Apomorphine; Choline; Disease Models, Animal; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Rats; Receptors, Dopamine; Stereotyped Behavior; Time Factors | 1978 |
Some neuropharmacological aspects of schizophrenia: a short review.
Topics: Amphetamines; Animals; Apomorphine; Disease Models, Animal; Hallucinogens; Humans; Psychoses, Substance-Induced; Rats; Schizophrenia, Paranoid | 1978 |
The effect of lithium on an animal model of tardive dyskinesia.
Topics: Animals; Apomorphine; Dextroamphetamine; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs; Haloperidol; Humans; Lithium; Male; Receptors, Dopamine; Stereotyped Behavior | 1977 |
Postsynaptic supersensitivity and kindling: further evidence of similarities.
Topics: Animals; Apomorphine; Behavior; Cocaine; Dextroamphetamine; Disease Models, Animal; Humans; Injections, Intraperitoneal; Rats; Receptors, Dopamine; Stereotyped Behavior; Time Factors | 1978 |
Levodopa-induced dopamine receptor hypersensitivity.
Topics: Animals; Apomorphine; Dextroamphetamine; Disease Models, Animal; Dyskinesia, Drug-Induced; Humans; Levodopa; Mice; Receptors, Dopamine; Stereotyped Behavior | 1977 |
Dopaminergic agonists in animal models of parkinsonism.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Cats; Disease Models, Animal; Haplorhini; Levodopa; Parkinson Disease, Secondary; Piribedil; Rats; Reserpine; Tyrosine | 1975 |
Effect of intracaudate drug injections on the striatal syndrome in reserpinized cats.
Topics: Animals; Apomorphine; Atropine; Cats; Caudate Nucleus; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Dopamine; Male; Neuromuscular Diseases; Parkinson Disease; Reserpine; Syndrome | 1977 |
Amphetamine induced turning behavior as an index of stroke in the Mongolian gerbil.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Carotid Arteries; Cerebrovascular Disorders; Disease Models, Animal; Gerbillinae; Time Factors | 1977 |
Effect of local application of apomorphine to the corpus striatum and to the nucleus accumbens on the reserpine-induced rigidity in rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Muscle Rigidity; Nucleus Accumbens; Rats; Reserpine; Septal Nuclei | 1977 |
Reinstatement of eating by dopamine agonists in aphagic dopamine denervated rats.
Topics: Animals; Apomorphine; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Humans; Hydroxydopamines; Hypothalamus; Levodopa; Male; Motor Activity; Nerve Degeneration; Parkinson Disease; Piperazines; Rats; Receptors, Dopamine; Stereotyped Behavior; Stimulation, Chemical | 1976 |
Amphetamine-induced dopaminergic hypersensitivity in guinea pigs. Implications in psychosis and human movement disorders.
Topics: Amphetamine; Animals; Apomorphine; Behavior; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Levodopa; Movement Disorders; Psychoses, Substance-Induced; Reaction Time; Receptors, Drug; Schizophrenia; Stereotyped Behavior; Substance-Related Disorders | 1975 |
Actions of dopaminergic agonists on motor function.
Topics: Amantadine; Animals; Apomorphine; Behavior; Dextroamphetamine; Disease Models, Animal; Dopamine Antagonists; Humans; Hyperkinesis; Levodopa; Methylphenidate; Motor Activity; Movement Disorders; Phenethylamines; Piribedil; Rats; Stereotyped Behavior; Tyrosine | 1975 |
Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dibenzoxazepines; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Haloperidol; Homovanillic Acid; Humans; Loxapine; Male; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior; Substance Withdrawal Syndrome | 1975 |
Supersensitivity to d-amphetamine- and apomorphine-induced stereotyped behavior induced by chronic d-amphetamine administration.
Topics: Animals; Apomorphine; Behavior; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Dopamine; Humans; Levodopa; Male; Mice; Movement Disorders; Parkinson Disease; Receptors, Drug; Stereotyped Behavior; Time Factors | 1975 |
Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamines; Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Dopamine; Female; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Motor Activity; Nalidixic Acid; Naphthyridines | 1992 |
Basic fibroblast growth factor ameliorates rotational behavior of substantia nigral-transplanted rats with lesions of the dopaminergic nigrostriatal neurons.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Fibroblast Growth Factor 2; Gliosis; Immunohistochemistry; Neural Pathways; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra | 1992 |
[The antiemetic activity of buspirone].
Topics: Animals; Antiemetics; Apomorphine; Buspirone; Cisplatin; Columbidae; Disease Models, Animal; Drug Evaluation, Preclinical; Vomiting | 1992 |
Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Fetus; Huntington Disease; Immunosuppression Therapy; Papio; Regression Analysis; Transplantation, Heterologous | 1992 |
Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior.
Topics: Amphetamine; Animals; Apomorphine; Axons; Denervation; Disease Models, Animal; Female; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Rotation; Substantia Nigra; Tyrosine 3-Monooxygenase | 1991 |
Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism.
Topics: Adrenal Medulla; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Graft Survival; Immunohistochemistry; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Rotation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Sympathectomy, Chemical; Tyrosine 3-Monooxygenase | 1991 |
Baseline and apomorphine-induced extracellular levels of nigral substance P are increased in an animal model of Parkinson's disease.
Topics: Animals; Apomorphine; Dialysis; Disease Models, Animal; Dopamine; Ganglia, Sympathetic; Hydroxydopamines; Neurons; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Melatonin modulates apomorphine-induced rotational behaviour.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Hydroxydopamines; Male; Melatonin; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Positive and negative interactions in the behavioural expression of D1 and D2 receptor stimulation in a model of Parkinsonism: role of priming.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Disease Models, Animal; Dopamine Antagonists; Hydroxydopamines; Male; Oxidopamine; Parkinson Disease; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Stereotyped Behavior | 1991 |
Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia.
Topics: Administration, Topical; Animals; Anterior Chamber; Apomorphine; Disease Models, Animal; Eye; Intraocular Pressure; Macaca mulatta; Myopia; Refraction, Ocular | 1991 |
Mechanisms of action of adrenal medulla grafts: the possible role of peripheral and central dopamine systems.
Topics: Adrenal Medulla; Adrenalectomy; Amphetamine; Animals; Apomorphine; Blood-Brain Barrier; Cerebral Ventricles; Corpus Striatum; Disease Models, Animal; Dopamine; Female; Hydroxydopamines; Male; Models, Biological; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Transplantation, Heterotopic | 1990 |
A functional assessment of embryonic dopaminergic grafts in the marmoset.
Topics: Amphetamine; Animals; Apomorphine; Brain Tissue Transplantation; Callitrichinae; Corpus Striatum; Disease Models, Animal; Dopamine; Fetal Tissue Transplantation; Functional Laterality; Hydroxydopamines; Mesencephalon; Motor Activity; Motor Skills; Oxidopamine; Parkinson Disease | 1990 |
A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Diseases; Caudate Nucleus; Disease Models, Animal; Dystonia; Female; Huntington Disease; Ibotenic Acid; Male; Motor Activity; Movement; Papio; Putamen | 1990 |
Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Fetal Tissue Transplantation; Huntington Disease; Ibotenic Acid; Male; Papio; Putamen; Rats; Species Specificity; Transplantation, Heterologous | 1990 |
Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Body Weight; Corpus Striatum; Disease Models, Animal; Dopamine; Hydrazines; Levodopa; Male; Methyltyrosines; Mice; Mice, Inbred C57BL; Motor Activity; Parkinson Disease, Secondary; Receptors, Dopamine; Stereotyped Behavior | 1990 |
Preliminary report on adrenal medullary grafting and cografting with sural nerve in the treatment of hemiparkinson monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Medulla; Animals; Apomorphine; Behavior, Animal; Carbidopa; Caudate Nucleus; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Macaca mulatta; Motor Activity; Parkinson Disease; Sural Nerve; Transplantation, Heterotopic | 1990 |
Is experimental catalepsy properly measured?
Topics: Adrenal Glands; Animals; Apomorphine; Catalepsy; Disease Models, Animal; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains | 1990 |
An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats.
Topics: Acrylic Resins; Animals; Apomorphine; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Implants; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Polyvinyls; Rats; Rats, Inbred Strains | 1989 |
A 6-hydroxydopamine-induced selective parkinsonian rat model.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Disease Models, Animal; Functional Laterality; Hydroxydopamines; Limbic System; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereotyped Behavior | 1989 |
Brain iron: a lesson from animal models.
Topics: Amphetamine; Anemia, Hypochromic; Animals; Antipsychotic Agents; Apomorphine; beta-Endorphin; Body Temperature Regulation; Brain; Disease Models, Animal; Dopamine; Iron; Iron Deficiencies; Learning; Motor Activity; Pain; Rats; Receptors, Dopamine; Sensory Thresholds | 1989 |
[The placebo effect: between mind and brain].
Topics: Animals; Apomorphine; Brain; Conditioning, Psychological; Disease Models, Animal; Humans; Parkinson Disease; Placebos | 1989 |
The pathophysiology of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Chlorpromazine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Fluphenazine; Guinea Pigs; Haloperidol; Humans; Receptors, Dopamine; Stereotyped Behavior; Thioridazine; Time Factors | 1985 |
Performance deficit induced by low doses of dopamine agonists in rats. Toward a model for approaching the neurobiology of negative schizophrenic symptomatology?
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Male; Phenothiazines; Pimozide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reinforcement Schedule; Reinforcement, Psychology; Schizophrenia; Schizophrenic Psychology; Sulpiride | 1986 |
Conditioning of the early behavioral response to apomorphine in the rotational model of Parkinson's disease.
Topics: Animals; Apomorphine; Conditioning, Psychological; Disease Models, Animal; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains | 1988 |
Changes in dopamine autoreceptor sensitivity in an animal model of depression.
Topics: Animals; Apomorphine; Body Weight; Depression; Desipramine; Disease Models, Animal; Eating; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stress, Physiological | 1988 |
Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome.
Topics: Animals; Apomorphine; Avoidance Learning; Biogenic Amines; Brain Chemistry; Disease Models, Animal; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Mice; Mice, Transgenic; Motor Activity; Mutation; Reference Values; Reflex; Swimming | 1988 |
L-5-HTP-induced myoclonic jumping behavior in guinea pigs: an update.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Bromocriptine; Clonazepam; Disease Models, Animal; Guinea Pigs; Haloperidol; Lisuride; Morphine; Myoclonus; Naloxone; Scopolamine; Tremorine | 1986 |
Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Brain; Brain Chemistry; Carbidopa; Carotid Artery, Internal; Disease Models, Animal; Dominance, Cerebral; Dopamine; Homovanillic Acid; Injections, Intra-Arterial; Levodopa; Macaca fascicularis; Movement; Neurons; Parkinson Disease, Secondary; Pyridines | 1986 |
Terguride, a mixed dopamine agonist-antagonist, in animal models of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain; Disease Models, Animal; Ergolines; Levodopa; Lisuride; Male; Motor Activity; Parkinson Disease; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1987 |
Influence of changes in brain monoamine metabolism on behaviour of herpes simplex-infected mice.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Brain; Clonidine; Dihydroxyphenylalanine; Disease Models, Animal; Disulfides; Dopamine; Dopamine beta-Hydroxylase; Fenclonine; Herpes Simplex; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methyltyrosines; Mice; Motor Activity; Norepinephrine; Phenoxybenzamine; Pimozide; Receptors, Adrenergic; Serotonin; Tyrosine 3-Monooxygenase; Vaccinia; Virus Cultivation | 1974 |
6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: effect on amphetamine-induced stereotyped behavior in rats.
Topics: Amphetamine; Animals; Apomorphine; Behavior; Behavior, Animal; Brain Chemistry; Brain Mapping; Caudate Nucleus; Disease Models, Animal; Dopamine; Histocytochemistry; Humans; Hydroxydopamines; Limbic System; Male; Microscopy, Fluorescence; Nerve Degeneration; Neural Pathways; Olfactory Bulb; Psychoses, Substance-Induced; Rats; Stereotyped Behavior; Synaptic Transmission | 1974 |
Biochemical aspects of experimentally induced parkinsonism.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Animals; Antiparkinson Agents; Apomorphine; Basal Ganglia; Biogenic Amines; Brain; Carboxy-Lyases; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine beta-Hydroxylase; Haplorhini; Humans; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Tyrosine 3-Monooxygenase; Visual Cortex | 1972 |
Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Drinking Behavior; Electric Stimulation; Electromyography; Feeding and Eating Disorders; Feeding Behavior; Humans; Hydroxydopamines; Levodopa; Motor Neurons; Muscle Contraction; Nerve Degeneration; Neural Pathways; Parkinson Disease; Parkinson Disease, Secondary; Perceptual Disorders; Rats; Reflex, Stretch; Substantia Nigra | 1974 |
An experimental model of tardive dyskinesia.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Movement Disorders; Stereotyped Behavior | 1972 |
Dopamine receptor site sensitivity in hyperthyroid guinea pigs: a possible model of hyperthyroid chorea.
Topics: Animals; Apomorphine; Behavior, Animal; Chorea; Corpus Striatum; Disease Models, Animal; Dopamine; Guinea Pigs; Humans; Hyperthyroidism; Male; Receptors, Drug; Stereotyped Behavior; Thyroxine | 1973 |
Bait-shyness acquisition is impaired by VMH lesions that produce obesity.
Topics: Animal Nutritional Physiological Phenomena; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Cues; Disease Models, Animal; Drinking Behavior; Eating; Extinction, Psychological; Feeding Behavior; Female; Hypothalamus; Injections, Intraperitoneal; Obesity; Rats; Saccharin; Taste | 1972 |
[Dependence of the anti-inflammatory effect of reserpine, caffeine and apomorphine on adrenal medulla in rats].
Topics: Adrenal Medulla; Animals; Anti-Inflammatory Agents; Apomorphine; Caffeine; Catecholamines; Disease Models, Animal; Edema; Rats; Reserpine | 1972 |
The neuroleptics. 3. Pharmacology. Introduction.
Topics: Amphetamine; Animals; Apomorphine; Avoidance Learning; Behavior; Behavior, Animal; Blepharoptosis; Brain; Catalepsy; Chemical Phenomena; Chemistry; Conditioning, Psychological; Disease Models, Animal; Dopamine Antagonists; Humans; Psychotic Disorders; Self Stimulation; Tranquilizing Agents | 1970 |
Observations on the pathogenesis of Reye's syndrome.
Topics: Adipose Tissue; Animals; Apomorphine; Brain Diseases; Child; Child, Preschool; Disease Models, Animal; Dogs; Fatty Liver; Female; Hepatitis; Humans; Hypoglycemia; Infant; Kidney Diseases; Leukocytes; Lipid Metabolism; Male; Organ Size; Virus Diseases; Vomiting | 1971 |