apnea and Patency of the Ductus Arteriosus studies

Research Excerpts

Excerpt	Relevance	Reference
"Aminophylline was effective for the prevention of apnea and intubation for apnea associated with PGE1 in infants with ductal-dependent congenital heart disease."	9.10	Aminophylline for the prevention of apnea during prostaglandin E1 infusion. ( Charpie, JR; Crowley, DC; Kim, DW; Kulik, TJ; Lim, DS; Maher, KO, 2003)
"Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP)."	7.83	Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity. ( Brouwer, E; Onland, W; Rijken, M; Te Pas, AB; Ten Hove, CH; van Kaam, AH; van Wassenaer-Leemhuis, AG; Vliegenthart, RJ, 2016)
" All postoperative apneas were identified."	7.74	The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? ( Ansermino, M; Milner, R; Murphy, JJ; Swanson, T, 2008)
"Periods of apnea or severe hypoventilation may occur during procedures which involve the airway or during thoracic operations."	7.66	Transcutaneous gas tension monitoring in the management of intraoperative apnea. ( Harley, DP; Hauser, CJ, 1983)
" Infants in the restrictive-transfusion group were more likely to have intraparenchymal brain hemorrhage or periventricular leukomalacia, and they had more frequent episodes of apnea, including both mild and severe episodes."	5.11	Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. ( Bell, EF; Cress, GA; Johnson, KJ; Kromer, IJ; Mahoney, LT; Mock, DM; Seward, VJ; Strauss, RG; Widness, JA; Zimmerman, MB, 2005)
"Aminophylline was effective for the prevention of apnea and intubation for apnea associated with PGE1 in infants with ductal-dependent congenital heart disease."	5.10	Aminophylline for the prevention of apnea during prostaglandin E1 infusion. ( Charpie, JR; Crowley, DC; Kim, DW; Kulik, TJ; Lim, DS; Maher, KO, 2003)
"Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction."	4.98	Caffeine controversies. ( Carlo, WA; Gentle, SJ; Travers, CP, 2018)
"Apnea of prematurity (AOP) is a common and pervasive problem in very low birth weight infants."	4.98	Caffeine: an evidence-based success story in VLBW pharmacotherapy. ( Dobson, NR; Hunt, CE, 2018)
"The introduction of methylxanthines, especially caffeine, for the treatment of apnea of prematurity has been one of the most important and effective therapies in the neonatal intensive care unit (NICU) to date."	4.88	Evidence-based methylxanthine use in the NICU. ( Spitzer, AR, 2012)
" These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant."	4.76	A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984)
" Side effects of apnea and fever are often dose dependent and occur within 48 h after initiation."	4.31	Standardizing Prostaglandin Initiation in Prenatally Diagnosed Ductal-Dependent Neonates; A Quality Initiative. ( Conaway, MR; Dean, PN; Elliott, MR; Haughey, BS; Swanson, JR; White, SC; Wiggin, JY, 2023)
"Caffeine to prevent or treat apnea of prematurity in the newborn period is now standard of care for infants born very preterm."	3.96	Childhood respiratory outcomes after neonatal caffeine therapy. ( Cheong, JLY; Doyle, LW, 2020)
"346), apnea (OR = 2."	3.88	Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors. ( Mu, D; Qu, Y; Tong, Y; Wu, T; Xia, B; Zhang, L, 2018)
"Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP)."	3.83	Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity. ( Brouwer, E; Onland, W; Rijken, M; Te Pas, AB; Ten Hove, CH; van Kaam, AH; van Wassenaer-Leemhuis, AG; Vliegenthart, RJ, 2016)
"In very preterm neonates, early (prophylactic) caffeine use was associated with a reduction in the rates of death or bronchopulmonary dysplasia and patent ductus arteriosus."	3.81	Association of early caffeine administration and neonatal outcomes in very preterm neonates. ( Barrington, K; Lee, SK; Lodha, A; McMillan, DD; Seshia, M; Shah, PS; Yang, J, 2015)
" All postoperative apneas were identified."	3.74	The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? ( Ansermino, M; Milner, R; Murphy, JJ; Swanson, T, 2008)
"Periods of apnea or severe hypoventilation may occur during procedures which involve the airway or during thoracic operations."	3.66	Transcutaneous gas tension monitoring in the management of intraoperative apnea. ( Harley, DP; Hauser, CJ, 1983)
" The most frequent complications are apnea with bradycardia and/or a significant left-to-right shunt through a patent ductus arteriosus."	3.66	The immature lung: radiographic appearance, course, and complications. ( Edwards, DK; Gluck, L; Jacob, J, 1980)
"To characterize the dosing and safety of off-label caffeine citrate in a contemporary cohort of extremely premature infants."	1.51	Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants. ( Bendel-Stenzel, E; Chhabra, R; Harper, B; Ku, L; Laughon, M; Moya, F; Payne, EH; Puia-Dumitrescu, M; Smith, PB; Soriano, A; Wade, KC; Zhao, J, 2019)
" Qualitative and quantitative differences in pharmacokinetics and pharmacodynamics of drugs should be considered before dosage regimens can be established."	1.27	[Peculiarities of drug therapy in childhood]. ( Kusenbach, G; Reinhardt, D, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (51.43)	18.7374
1990's	1 (2.86)	18.2507
2000's	5 (14.29)	29.6817
2010's	9 (25.71)	24.3611
2020's	2 (5.71)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Early Use of Caffeine Citrate in Preterm Neonates Needing Respiratory Support.[NCT04001712]	Phase 3	54 participants (Actual)	Interventional	2019-04-05	Completed
A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates[NCT03086473]	Phase 4	24 participants (Actual)	Interventional	2017-02-01	Active, not recruiting
Randomized Trial of Liberal Versus Restrictive Guidelines for Red Blood Cell Transfusion in Preterm Infants[NCT00369005]		100 participants	Interventional	1992-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Caffeine controversies. Current opinion in pediatrics, 2018, Volume: 30, Issue:2 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Central Nervous System Stimulants; Drug Administration	2018
Caffeine: an evidence-based success story in VLBW pharmacotherapy. Pediatric research, 2018, Volume: 84, Issue:3 Topics: Apnea; Caffeine; Central Nervous System Stimulants; Ductus Arteriosus, Patent; Enterocolitis, Necrot	2018
Evidence-based methylxanthine use in the NICU. Clinics in perinatology, 2012, Volume: 39, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Evidence-Based Medicine; Humans; Infan	2012
A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics, 1984, Volume: 73, Issue:1 Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu	1984
Clinical uses of transcutaneous oxygen monitoring. Advances in pediatrics, 1981, Volume: 28 Topics: Apnea; Blood Pressure; Ductus Arteriosus, Patent; Electrodes; Enterocolitis, Pseudomembranous; Human	1981
Mechanical ventilation in newborn infants with hyaline membrane disease;. Pediatric annals, 1977, Volume: 6, Issue:4 Topics: Acidosis; Apnea; Birth Weight; Bradycardia; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Gestatio	1977
[Drug therapy of patent ductus arteriosus in premature and newborn infants]. Kinderarztliche Praxis, 1978, Volume: 46, Issue:12 Topics: Apnea; Aspirin; Chloroquine; Digitalis Glycosides; Ductus Arteriosus, Patent; Humans; Indomethacin;	1978
Difficulties in distinguishing cardiac from pulmonary disease in the neonate. Pediatric clinics of North America, 1973, Volume: 20, Issue:2 Topics: Apnea; Arteriovenous Malformations; Carbon Dioxide; Cardiovascular System; Cyanosis; Diagnosis, Diff	1973

Article	Year
Aminophylline for the prevention of apnea during prostaglandin E1 infusion. Pediatrics, 2003, Volume: 112, Issue:1 Pt 1 Topics: Alprostadil; Aminophylline; Apnea; Bradycardia; Bronchodilator Agents; Double-Blind Method; Ductus A	2003
Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics, 2005, Volume: 115, Issue:6 Topics: Anemia; Apnea; Blood Donors; Brain Damage, Chronic; Bronchopulmonary Dysplasia; Cerebral Hemorrhage;	2005

Article	Year
Standardizing Prostaglandin Initiation in Prenatally Diagnosed Ductal-Dependent Neonates; A Quality Initiative. Pediatric cardiology, 2023, Volume: 44, Issue:6 Topics: Alprostadil; Apnea; Cardiac Surgical Procedures; Ductus Arteriosus, Patent; Heart Defects, Congenita	2023
Childhood respiratory outcomes after neonatal caffeine therapy. Seminars in fetal & neonatal medicine, 2020, Volume: 25, Issue:6 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Central Nervous System Stimulants; Child; Citrates; Duc	2020
Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors. Investigative ophthalmology & visual science, 2018, 02-01, Volume: 59, Issue:2 Topics: Apnea; Birth Weight; Blood Transfusion; Bronchopulmonary Dysplasia; China; Ductus Arteriosus, Patent	2018
Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants. The Journal of pediatrics, 2019, Volume: 211 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Cerebral Hemorrhage; Citrates; Ductus Arteriosus, Paten	2019
Association of early caffeine administration and neonatal outcomes in very preterm neonates. JAMA pediatrics, 2015, Volume: 169, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Canada; Ductus Arteriosus, Patent; Gestational Age; Hum	2015
Association of early caffeine administration and neonatal outcomes in very preterm neonates. JAMA pediatrics, 2015, Volume: 169, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Canada; Ductus Arteriosus, Patent; Gestational Age; Hum	2015
Association of early caffeine administration and neonatal outcomes in very preterm neonates. JAMA pediatrics, 2015, Volume: 169, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Canada; Ductus Arteriosus, Patent; Gestational Age; Hum	2015
Association of early caffeine administration and neonatal outcomes in very preterm neonates. JAMA pediatrics, 2015, Volume: 169, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Canada; Ductus Arteriosus, Patent; Gestational Age; Hum	2015
Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity. Neonatology, 2016, Volume: 110, Issue:1 Topics: Apnea; Bronchopulmonary Dysplasia; Central Nervous System Stimulants; Child Development; Doxapram; D	2016
Immunization Status of NICU Graduates at a Tertiary Care Children's Hospital. Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2017, Volume: 17, Issue:2 Topics: Adrenal Cortex Hormones; Age Factors; Apnea; Bradycardia; Bronchopulmonary Dysplasia; Continuous Pos	2017
Reduced frequency of apnea and bradycardia episodes caused by exposure to biological maternal sounds. Pediatrics international : official journal of the Japan Pediatric Society, 2012, Volume: 54, Issue:2 Topics: Abruptio Placentae; Apgar Score; Apnea; Bradycardia; Cesarean Section; Continuous Positive Airway Pr	2012
Mesenteric oxyhemoglobin desaturation improves with patent ductus arteriosus ligation. Journal of perinatology : official journal of the California Perinatal Association, 2006, Volume: 26, Issue:9 Topics: Apnea; Cerebellum; Ductus Arteriosus, Patent; Echocardiography; Embolization, Therapeutic; Female; H	2006
Caffeine for apnea of prematurity. The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9 Topics: Apnea; Bronchopulmonary Dysplasia; Caffeine; Central Nervous System Stimulants; Ductus Arteriosus, P	2006
The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? Journal of pediatric surgery, 2008, Volume: 43, Issue:5 Topics: Apnea; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Comorbidity; Ductus Arteriosus, Patent; Fema	2008
Transcutaneous gas tension monitoring in the management of intraoperative apnea. Critical care medicine, 1983, Volume: 11, Issue:10 Topics: Adult; Apnea; Blood Gas Analysis; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Intraoperative	1983
Acute proliferative retrolental fibroplasia: multivariate risk analysis. Transactions of the American Ophthalmological Society, 1983, Volume: 81 Topics: Analysis of Variance; Anemia; Apnea; Birth Weight; Bronchopulmonary Dysplasia; Cerebral Hemorrhage;	1983
The immature lung: radiographic appearance, course, and complications. AJR. American journal of roentgenology, 1980, Volume: 135, Issue:4 Topics: Apnea; Body Weight; Bradycardia; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Female;	1980
Pathogenesis of neonatal apnoea. Developmental medicine and child neurology, 1977, Volume: 19, Issue:5 Topics: Apnea; Ductus Arteriosus, Patent; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung Volume Me	1977
[Indomethacin in IRDS with PDA phenomenon (author's transl)]. Klinische Padiatrie, 1979, Volume: 191, Issue:5 Topics: Apnea; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Respiratory Distress Syndro	1979
Neurological and electroencephalographic changes in newborns treated with prostaglandins E1 and E2. Prostaglandins, 1977, Volume: 13, Issue:5 Topics: Apnea; Brain; Cyanosis; Ductus Arteriosus, Patent; Electroencephalography; Heart Defects, Congenital	1977
Surgical closure of patent ductus arteriosus in the premature infant with respiratory distress. Journal of pediatric surgery, 1975, Volume: 10, Issue:3 Topics: Aortography; Apnea; Birth Weight; Blood Pressure; Ductus Arteriosus, Patent; Electrocardiography; Fe	1975
Early neonatal hypocalcaemia. Archives of disease in childhood, 1975, Volume: 50, Issue:8 Topics: Apnea; Asphyxia Neonatorum; Birth Weight; Calcium; Ductus Arteriosus, Patent; Erythroblastosis, Feta	1975
Doppler ultrasound study of the anterior cerebral artery in neonates. Journal of neuroradiology = Journal de neuroradiologie, 1991, Volume: 18, Issue:4 Topics: Apnea; Asphyxia Neonatorum; Blood Flow Velocity; Cerebral Arteries; Cerebral Hemorrhage; Cerebrovasc	1991
Role of theophylline in pathogenesis of necrotizing enterocolitis. The Journal of pediatrics, 1986, Volume: 109, Issue:2 Topics: Apgar Score; Apnea; Birth Weight; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Gestat	1986
[Peculiarities of drug therapy in childhood]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:11 Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone;	1986
Studies on pulmonary mechanics in infants. Acta paediatrica Scandinavica. Supplement, 1974, Volume: Suppl 244, Issue:0 Topics: Airway Resistance; Apnea; Asphyxia Neonatorum; Catheterization; Ductus Arteriosus, Patent; Heart Sep	1974
Anaesthetic management of a very premature infant. Case report. British journal of anaesthesia, 1972, Volume: 44, Issue:7 Topics: Acid-Base Equilibrium; Anesthesia, General; Apnea; Body Temperature; Ductus Arteriosus, Patent; Fema	1972
Management of premature infants with patent ductus arteriosus. The Journal of thoracic and cardiovascular surgery, 1974, Volume: 67, Issue:2 Topics: Apnea; Digitalis; Diuretics; Ductus Arteriosus, Patent; Female; Heart Auscultation; Heart Defects, C	1974

apnea and Patency of the Ductus Arteriosus

Research Excerpts

Research

Studies (35)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Haughey, BS	1
Elliott, MR	1
Wiggin, JY	1
Conaway, MR	1
White, SC	1
Swanson, JR	1
Dean, PN	1
Cheong, JLY	1
Doyle, LW	1
Gentle, SJ	1
Travers, CP	1
Carlo, WA	1
Wu, T	1
Zhang, L	1
Tong, Y	1
Qu, Y	1
Xia, B	1
Mu, D	1
Dobson, NR	1
Hunt, CE	1
Puia-Dumitrescu, M	1
Smith, PB	1
Zhao, J	1
Soriano, A	1
Payne, EH	1
Harper, B	1
Bendel-Stenzel, E	1
Moya, F	1
Chhabra, R	1
Ku, L	1
Laughon, M	1
Wade, KC	1
Lodha, A	1
Seshia, M	1
McMillan, DD	1
Barrington, K	1
Yang, J	1
Lee, SK	1
Shah, PS	1
Ten Hove, CH	1
Vliegenthart, RJ	1
Te Pas, AB	1
Brouwer, E	1
Rijken, M	1
van Wassenaer-Leemhuis, AG	1
van Kaam, AH	1
Onland, W	1
Macintosh, JLB	1
Huggins, LJ	1
Eden, LM	1
Merrill, KC	1
Luthy, KEB	1
Spitzer, AR	2
Doheny, L	1
Morey, JA	1
Ringer, SA	1
Lahav, A	1
Lim, DS	1
Kulik, TJ	1
Kim, DW	1
Charpie, JR	1
Crowley, DC	1
Maher, KO	1
Bell, EF	1
Strauss, RG	1
Widness, JA	1
Mahoney, LT	1
Mock, DM	1
Seward, VJ	1
Cress, GA	1
Johnson, KJ	1
Kromer, IJ	1
Zimmerman, MB	1
Meier, SD	1
Eble, BK	1
Stapleton, GE	1
Morales, DL	1
Chang, AC	1
Andropoulos, DB	1
Hand, IL	1
Noble, LM	1
Murphy, JJ	1
Swanson, T	1
Ansermino, M	1
Milner, R	1
Lucey, JF	2
Dangman, B	1
Hauser, CJ	1
Harley, DP	1
Flynn, JT	1
Edwards, DK	1
Jacob, J	1
Gluck, L	1
Habel, A	1
Jones, MD	1
Murton, LJ	1
Bartel, J	1
Müller, WD	1
Zach, M	1
Stix, H	1
Rosegger, H	1
Beitzke, A	1
Fariello, R	1
Olley, PM	1
Coceani, F	1
Coran, AG	1
Cabal, L	1
Siassi, B	1
Rosenkrantz, JG	1
Roberton, NR	1
Smith, MA	1
Sevely, A	1
Fries, F	1
Regnier, C	1
Manelfe, C	1
Davis, JM	1
Abbasi, S	1
Johnson, L	1
Reinhardt, D	1
Kusenbach, G	1
Ahlström, H	1
Smith, PC	1
Smith, NT	1
Sahn, DJ	1
Friedman, WF	1
Murphy, DA	1
Outerbridge, E	1
Stern, L	1
Karn, GM	1
Jegier, W	1
Rosales, J	1