apnea has been researched along with Leigh Disease in 3 studies
Apnea: A transient absence of spontaneous respiration.
Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mutant mice manifested a progressive increase in apnea and had aberrant responses to hypoxia." | 3.78 | Fatal breathing dysfunction in a mouse model of Leigh syndrome. ( Koch, H; Kruse, SE; Lee, D; Palmiter, RD; Quintana, A; Ramirez, JM; Zanella, S, 2012) |
| ", intrauterine growth restriction, central apnea, and feeding difficulty." | 3.75 | Diffusion-weighted imaging in preclinical Leigh syndrome. ( Asada, J; Fujisawa, I; Hata, D; Kumakura, A; Okumura, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumakura, A | 1 |
| Asada, J | 1 |
| Okumura, R | 1 |
| Fujisawa, I | 1 |
| Hata, D | 1 |
| Quintana, A | 1 |
| Zanella, S | 1 |
| Koch, H | 1 |
| Kruse, SE | 1 |
| Lee, D | 1 |
| Ramirez, JM | 1 |
| Palmiter, RD | 1 |
| Morris, SA | 1 |
| Harbord, MG | 1 |
3 other studies available for apnea and Leigh Disease
| Article | Year |
|---|---|
Diffusion-weighted imaging in preclinical Leigh syndrome.
Topics: Apnea; Brain; Child, Preschool; Consciousness Disorders; Diagnosis, Differential; Diffusion Magnetic | 2009 |
Fatal breathing dysfunction in a mouse model of Leigh syndrome.
Topics: Action Potentials; Analysis of Variance; Animals; Apnea; Brain Stem; Dependovirus; Disease Models, A | 2012 |
Infant onset subacute necrotizing encephalomyelopathy (Leigh's disease)
Topics: Apnea; Blindness; Female; Humans; Infant; Lactates; Lactic Acid; Leigh Disease; Male; Seizures | 1993 |