apnea has been researched along with Down Syndrome in 2 studies
Apnea: A transient absence of spontaneous respiration.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obstructive Sleep Apnea Syndrome (OSAS) is common in children with Down syndrome (DS)." | 3.74 | OSAS in Down syndrome: T&A versus T&A plus lateral pharyngoplasty. ( Merrell, JA; Shott, SR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merrell, JA | 1 |
| Shott, SR | 1 |
| Boseley, ME | 1 |
| Hartnick, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Control Trial of Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea[NCT06043440] | Phase 2 | 230 participants (Anticipated) | Interventional | 2023-09-27 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for apnea and Down Syndrome
| Article | Year |
|---|---|
OSAS in Down syndrome: T&A versus T&A plus lateral pharyngoplasty.
Topics: Adenoidectomy; Apnea; Arousal; Child, Preschool; Down Syndrome; Female; Humans; Hypoxia; Male; Otorh | 2007 |
A useful algorithm for managing the difficult pediatric airway.
Topics: Adolescent; Airway Obstruction; Algorithms; Apnea; Down Syndrome; Equipment Design; Female; Humans; | 2007 |