aplysin and Enteritis

Aplysin, a kind of phytochemicals or phytonutrients, is purified from red alga Laurencia tristicha. The present study aims to investigate the influence of aplysin on changes of intestinal permeability and microbiota induced by excessive ethanol and iron. Thirty male rats were randomly divided into three groups (10/group): control group (normal saline); ethanol + iron group as EI treated with ethanol (8⁻12 mL/kg/day) and iron (1000 mg/kg) in diet; EI supplemented with aplysin (150 mg/kg/day) group as AEI; the trial lasts for 12 weeks. The result showed that levels of plasma endotoxin, fatty acid-binding protein 2, D-lactic acid, diamine oxidase were increased in rats in the EI group; and significantly decreased by 14%, 17%, 26%, 16%, respectively (

Topics: Alcohol Drinking; Animals; Cation Transport Proteins; Dietary Supplements; Dysbiosis; Enteritis; Gastrointestinal Agents; Gastrointestinal Microbiome; Hydrocarbons, Brominated; Intestinal Mucosa; Intestine, Small; Iron, Dietary; Male; Microscopy, Electron, Transmission; Oxidative Stress; Permeability; Protective Agents; Random Allocation; Rats, Wistar; Sesquiterpenes