apis and Virus-Diseases

apis has been researched along with Virus-Diseases* in 1 studies

Other Studies

1 other study(ies) available for apis and Virus-Diseases

Article	Year
Synthesis and Antiviral Activity Evaluation of 2',5',5'-Trifluoro-Apiosyl Nucleoside Phosphonic Acid Analogs. Nucleosides, nucleotides & nucleic acids, 2016, Volume: 35, Issue:3 Racemic synthesis of novel 2',5',5'-trifluoro-apiose nucleoside phosphonic acid analogs were performed as potent antiviral agents. Phosphonation was performed by direct displacement of triflate intermediate with diethyl (lithiodifluoromethyl) phosphonate to give the corresponding (α,α-difluoroalkyl) phosphonate. Condensation successfully proceeded from a glycosyl donor with persilylated bases to yield the nucleoside phosphonate analogs. Deprotection of diethyl phosphonates provided the target nucleoside analogs. An antiviral evaluation of the synthesized compounds against various viruses such as HIV, HSV-1, HSV-2, and HCMV revealed that the pyrimidine analogues have significant anti-HCMV activity. Topics: Antiviral Agents; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Nucleosides; Pentoses; Phosphorous Acids; Virus Diseases	2016

Article

Year

Synthesis and Antiviral Activity Evaluation of 2',5',5'-Trifluoro-Apiosyl Nucleoside Phosphonic Acid Analogs.

Nucleosides, nucleotides & nucleic acids, 2016, Volume: 35, Issue:3

Racemic synthesis of novel 2',5',5'-trifluoro-apiose nucleoside phosphonic acid analogs were performed as potent antiviral agents. Phosphonation was performed by direct displacement of triflate intermediate with diethyl (lithiodifluoromethyl) phosphonate to give the corresponding (α,α-difluoroalkyl) phosphonate. Condensation successfully proceeded from a glycosyl donor with persilylated bases to yield the nucleoside phosphonate analogs. Deprotection of diethyl phosphonates provided the target nucleoside analogs. An antiviral evaluation of the synthesized compounds against various viruses such as HIV, HSV-1, HSV-2, and HCMV revealed that the pyrimidine analogues have significant anti-HCMV activity.

Topics: Antiviral Agents; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Nucleosides; Pentoses; Phosphorous Acids; Virus Diseases

2016