apigenin-dimethylether and Disease-Models--Animal

apigenin-dimethylether has been researched along with Disease-Models--Animal* in 2 studies

Other Studies

2 other study(ies) available for apigenin-dimethylether and Disease-Models--Animal

Article	Year
Gastroprotective flavonoid constituents from Oroxylum indicum Vent. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Chemical investigation of the stem bark of Oroxylum indicum resulted in the isolation and characterization of two new flavonoid glycosides (1, 2), along with seven known compounds (3-9). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by the comparison with spectroscopic data reported in the literature. In addition, all the compounds were tested for their ulcer protective effects against various gastric ulceritis inducing models in rats. Topics: Animals; Anti-Ulcer Agents; Bignoniaceae; Disease Models, Animal; Flavanones; Flavones; Flavonoids; Magnetic Resonance Spectroscopy; Plant Bark; Plant Stems; Rats	2010
Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida. Journal of natural products, 2007, Volume: 70, Issue:3 Bioassay-guided fractionation of the combined fruits, leaves, and twigs (fruiting branches) of Callicarpa americana, collected from a plot in a forested area in southern Florida, led to the isolation of six new clerodane diterpenes (1-6) and eight known compounds. The structures of 1-6 [12(S),16xi-dihydroxycleroda-3,13-dien-15,16-olide (1), 12(S)-hydroxy-16xi-methoxycleroda-3,13-dien-15,16-olide (2), 12(S)-hydroxycleroda-3,13-dien-15,16-olide (3), 16xi-hydroxycleroda-3,11(E),13-trien-15,16-olide (4), 3beta,12(S)-dihydroxycleroda-4(18),13-dien-15,16-olide (5), and 12(S)-hydroxycleroda-3,13-dien-16,15-olide (6)] were elucidated by interpretation of spectroscopic data and chemical methods. The absolute configuration at C-12 in 1 and 3 was ascertained using the Mosher ester technique. The cytotoxicity of all isolates was tested against a panel of human cancer cell lines, and compounds 1, 4, and 6, and the known compounds genkwanin, 16xi-hydroxycleroda-3,13-dien-15,16-olide, and 2-formyl-16xi-hydroxy-3-A-norcleroda-2,13-dien-15,16-olide were active (ED50 <5 microg/mL). However, 1 was found to be inactive against human cancer cells implanted in mice using a hollow-fiber tumor model. Topics: Animals; Antineoplastic Agents, Phytogenic; Callicarpa; Disease Models, Animal; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Florida; Fruit; Humans; Mice; Molecular Structure; Plant Leaves; Plant Stems; Plants, Medicinal	2007

Article

Year

Gastroprotective flavonoid constituents from Oroxylum indicum Vent.

Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

Chemical investigation of the stem bark of Oroxylum indicum resulted in the isolation and characterization of two new flavonoid glycosides (1, 2), along with seven known compounds (3-9). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by the comparison with spectroscopic data reported in the literature. In addition, all the compounds were tested for their ulcer protective effects against various gastric ulceritis inducing models in rats.

Topics: Animals; Anti-Ulcer Agents; Bignoniaceae; Disease Models, Animal; Flavanones; Flavones; Flavonoids; Magnetic Resonance Spectroscopy; Plant Bark; Plant Stems; Rats

2010

Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.

Journal of natural products, 2007, Volume: 70, Issue:3

Bioassay-guided fractionation of the combined fruits, leaves, and twigs (fruiting branches) of Callicarpa americana, collected from a plot in a forested area in southern Florida, led to the isolation of six new clerodane diterpenes (1-6) and eight known compounds. The structures of 1-6 [12(S),16xi-dihydroxycleroda-3,13-dien-15,16-olide (1), 12(S)-hydroxy-16xi-methoxycleroda-3,13-dien-15,16-olide (2), 12(S)-hydroxycleroda-3,13-dien-15,16-olide (3), 16xi-hydroxycleroda-3,11(E),13-trien-15,16-olide (4), 3beta,12(S)-dihydroxycleroda-4(18),13-dien-15,16-olide (5), and 12(S)-hydroxycleroda-3,13-dien-16,15-olide (6)] were elucidated by interpretation of spectroscopic data and chemical methods. The absolute configuration at C-12 in 1 and 3 was ascertained using the Mosher ester technique. The cytotoxicity of all isolates was tested against a panel of human cancer cell lines, and compounds 1, 4, and 6, and the known compounds genkwanin, 16xi-hydroxycleroda-3,13-dien-15,16-olide, and 2-formyl-16xi-hydroxy-3-A-norcleroda-2,13-dien-15,16-olide were active (ED50 <5 microg/mL). However, 1 was found to be inactive against human cancer cells implanted in mice using a hollow-fiber tumor model.

Topics: Animals; Antineoplastic Agents, Phytogenic; Callicarpa; Disease Models, Animal; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Florida; Fruit; Humans; Mice; Molecular Structure; Plant Leaves; Plant Stems; Plants, Medicinal

2007