apigenin and Pancreatitis--Chronic

apigenin has been researched along with Pancreatitis--Chronic* in 1 studies

Other Studies

1 other study(ies) available for apigenin and Pancreatitis--Chronic

Article	Year
Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo. Bioorganic & medicinal chemistry, 2014, Jul-01, Volume: 22, Issue:13 Accumulating evidence suggests that activated pancreatic stellate cells (PSC) play an important role in chronic pancreatitis (CP), and inhibition of the activated PSC is considered as a potential strategy for the treatment and prevention of CP. Herein, we disclose our findings that apigenin and its novel analogues suppress the proliferation and induce apoptosis in PSC, which reduce the PSC-mediated fibrosis in CP. Chemical modifications of apigenin have been directed to build a focused library of O-alkylamino-tethered apigenin derivatives at 4'-O position of the ring C with the attempt to enhance the potency and drug-like properties including aqueous solubility. A number of compounds such as 14, 16, and 24 exhibited potent antiproliferative effects as well as improved aqueous solubility. Intriguingly, apigenin, new analogues 23 and 24 displayed significant efficacy to reduce pancreatic fibrosis even at a low dose of 0.5mg/kg in our proof-of-concept study using a preclinical in vivo mouse model of CP. Topics: Apigenin; Cell Death; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Fibrosis; Humans; Molecular Structure; Pancreatic Stellate Cells; Pancreatitis, Chronic; Solubility; Structure-Activity Relationship	2014

Article

Year

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.

Bioorganic & medicinal chemistry, 2014, Jul-01, Volume: 22, Issue:13

Accumulating evidence suggests that activated pancreatic stellate cells (PSC) play an important role in chronic pancreatitis (CP), and inhibition of the activated PSC is considered as a potential strategy for the treatment and prevention of CP. Herein, we disclose our findings that apigenin and its novel analogues suppress the proliferation and induce apoptosis in PSC, which reduce the PSC-mediated fibrosis in CP. Chemical modifications of apigenin have been directed to build a focused library of O-alkylamino-tethered apigenin derivatives at 4'-O position of the ring C with the attempt to enhance the potency and drug-like properties including aqueous solubility. A number of compounds such as 14, 16, and 24 exhibited potent antiproliferative effects as well as improved aqueous solubility. Intriguingly, apigenin, new analogues 23 and 24 displayed significant efficacy to reduce pancreatic fibrosis even at a low dose of 0.5mg/kg in our proof-of-concept study using a preclinical in vivo mouse model of CP.

Topics: Apigenin; Cell Death; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Fibrosis; Humans; Molecular Structure; Pancreatic Stellate Cells; Pancreatitis, Chronic; Solubility; Structure-Activity Relationship

2014