apigenin and Colonic-Neoplasms

apigenin has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for apigenin and Colonic-Neoplasms

Article	Year
Constituents of Chinese propolis and their antiproliferative activities. Journal of natural products, 2002, Volume: 65, Issue:5 Two new flavonoids, 3-O-[(S)-2-methylbutyroyl]pinobanksin (1) and 6-cinnamylchrysin (2), were isolated from the EtOAc-soluble fraction of the MeOH extract of Chinese propolis, along with 12 known compounds (3-14). The structures of the isolated compounds were elucidated on the basis of spectroscopic and chemical analyses. The isolated compounds were tested for their antiproliferative activity toward five different cancer cell lines. Benzyl caffeate (13) and phenethyl caffeate (14) showed potent antiproliferative activity toward tested cell lines with a selective activity toward colon 26-L5 carcinoma cell line (EC(50) values: 13, 1.01; 14, 0.30 microM). Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Caffeic Acids; China; Chromatography, Thin Layer; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flavonoids; Free Radical Scavengers; Mice; Molecular Structure; Phenylethyl Alcohol; Picrates; Propolis; Spectrophotometry, Infrared; Tumor Cells, Cultured	2002
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15 Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the "molecular saboteurs" to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti-neoplastic drugs. Topics: Animals; Base Sequence; Cell Division; Chamomile; Colonic Neoplasms; Cornea; DNA Primers; Enzyme Inhibitors; Female; Flavonoids; Glioblastoma; Glioma; Humans; Hyaluronoglucosaminidase; Melanoma; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Oils, Volatile; Plants, Medicinal; Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured	1996

Article

Year

Constituents of Chinese propolis and their antiproliferative activities.

Journal of natural products, 2002, Volume: 65, Issue:5

Two new flavonoids, 3-O-[(S)-2-methylbutyroyl]pinobanksin (1) and 6-cinnamylchrysin (2), were isolated from the EtOAc-soluble fraction of the MeOH extract of Chinese propolis, along with 12 known compounds (3-14). The structures of the isolated compounds were elucidated on the basis of spectroscopic and chemical analyses. The isolated compounds were tested for their antiproliferative activity toward five different cancer cell lines. Benzyl caffeate (13) and phenethyl caffeate (14) showed potent antiproliferative activity toward tested cell lines with a selective activity toward colon 26-L5 carcinoma cell line (EC(50) values: 13, 1.01; 14, 0.30 microM).

Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Caffeic Acids; China; Chromatography, Thin Layer; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flavonoids; Free Radical Scavengers; Mice; Molecular Structure; Phenylethyl Alcohol; Picrates; Propolis; Spectrophotometry, Infrared; Tumor Cells, Cultured

2002

Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15

Hyaluronic acid is a proteoglycan present in the extracellular matrix and is important for the maintenance of tissue architecture. Depolymerization of hyaluronic acid may facilitate tumor invasion. In addition, oligosaccharides of hyaluronic acid have been reported to induce angiogenesis. We report here that a hyaluronidase similar to the one on human sperm is expressed by metastatic human melanoma, colon carcinoma, and glioblastoma cell lines and by tumor biopsies from patients with colorectal carcinomas, but not by tissues from normal colon. Moreover, angiogenesis is induced by hyaluronidase+ tumor cells but not hyaluronidase- tumor cells and can be blocked by an inhibitor of hyaluronidase. Tumor cells thus use hyaluronidase as one of the "molecular saboteurs" to depolymerize hyaluronic acid to facilitate invasion. As a consequence, breakdown products of hyaluronic acid can further promote tumor establishment by inducing angiogenesis. Hyaluronidase on tumor cells may provide a target for anti-neoplastic drugs.

Topics: Animals; Base Sequence; Cell Division; Chamomile; Colonic Neoplasms; Cornea; DNA Primers; Enzyme Inhibitors; Female; Flavonoids; Glioblastoma; Glioma; Humans; Hyaluronoglucosaminidase; Melanoma; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Pathologic; Oils, Volatile; Plants, Medicinal; Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured

1996