apigenin and Burning-Mouth-Syndrome

Topics: Aged; Aged, 80 and over; Burning Mouth Syndrome; Chamomile; Female; Flax; Flowers; Humans; Matricaria; Middle Aged; Mouth; Phytotherapy; Plant Extracts; Saliva; Seeds; Xerostomia

The treatments for burning mouth syndrome (BMS) proposed to date have been varied but have only achieved limited efficacy. Chamomile has analgesic and anti-inflammatory properties. The aim of this study was to evaluate the efficacy of topical applications of 2% chamomile gel in comparison with a placebo for the treatment of BMS.. The study was designed as a prospective randomized placebo-controlled double-blind monocentric study. A total of 62 patients with idiopathic BMS were divided into two groups: Group A received applications of a 2% chamomile gel, and Group B (placebo) were administered a placebo; both treatments were applied twice daily for 1 month. Three variables were evaluated at base line, 15 and 30 days: pain (assessed using a visual analogue scale [VAS]), xerostomia severity (Xerostomia Inventory), and oral quality of life (assessed by means of the Oral Health Impact Profile-14).. A total of 57 patients completed the study. Pain, xerostomia, and quality of life underwent improvements with statistical significance at 15 and 30 days in both groups (P < 0.001). But when the two groups were compared, differences in VAS pain were not significant (P = 0.847), nor were xerostomia severity (P = 0.536), or oral quality of life (P = 0.076).. The chamomile gel product was well tolerated. As treatment with chamomile and the placebo produced similar outcomes, the efficacy of 2% chamomile gel for treating BMS appears questionable. However, further studies with larger patient samples are needed to confirm this.

Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Burning Mouth Syndrome; Chamomile; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Plant Extracts; Prospective Studies; Quality of Life; Surveys and Questionnaires; Xerostomia