apigenin and Asthma

Asthma is a chronic immune disease that has become a serious public health problem. The currently available medications are not ideal because of their limitations and side effects; hence, new target proteins and signaling cascades for precise and safe therapy treatment are needed. This work established an ovalbumin-induced asthma rat model and treated it with total flavonoid extract from the Xinjiang chamomile. The proteins that were differentially expressed in the chamomile extract-treated asthmatic rats and the asthma and healthy rat groups were identified using isobaric tagging followed by LC-MS/MS. Kyoto encyclopedia of genes and genomes pathway analysis of the differentially expressed proteins was performed.. Pathways involved in purine metabolism, herpes simplex infection, and JNK phosphorylation and activation mediated by activated human TAK1 were enriched, indicating the intrinsic links between the mechanism of asthma development and treatment effects. Furthermore, we constructed a protein-protein interaction network and identified KIF3A as a potential target protein of chamomile extract that affected the Hedgehog signaling pathway.. This study may provide new insights into the pathogenesis of asthma and reveal several proteins and pathways that could be exploited to develop novel treatment approaches.

Topics: Animals; Asthma; Chamomile; Flavonoids; Hedgehog Proteins; Kinesins; Lung; Plant Extracts; Protein Interaction Maps; Proteome; Proteomics; Rats; Signal Transduction

Topics: Adult; Asthma; Chamomile; Humans; Inhalation; Male; Occupational Diseases; Occupational Exposure

Topics: Allergens; Asthma; Calcium Compounds; Chamomile; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Female; Flowers; Hand Dermatoses; Humans; Intradermal Tests; Middle Aged; Oxides; Patch Tests; Rhinitis

Artemisia vulgaris is a common weed and an important source of allergens on the subtropical island of Tenerife, Canary Islands, Spain. It pollinates mainly from July to September, although, due to some local climatic conditions, it may flower throughout the year. Cross-reactivity with hazelnut, kiwi, birch, several Compositae (Ambrosia, Chrysanthemum, Matricaria, Solidago) and grass allergens has been suggested. Few studies have addressed the issue of in vivo cross-reactivity between A. vulgaris and Matricaria chamomilla. The objective of this study was to perform conjunctival and bronchial challenges with A. vulgaris and M. chamomilla and oral challenge with chamomile in 24 patients with asthma and/or rhinitis sensitized primarily to A. vulgaris. Skin prick tests with M. chamomilla were positive in 21 patients. Eighteen patients had a positive conjunctival provocation test with a A. vulgaris pollen extract and 13 patients had a positive conjunctival provocation test with a M. chamomilla pollen extract. Bronchial provocation tests with A. vulgaris were positive in 15 patients and with M. chamomilla pollen in another 16 individuals. Oral provocation tests, conducted with a commercial chamomile infusion were positive in 13 patients. Nine of these individuals were skin test positive to food allergens and 17 to others pollens of the Compositae family. This study confirms a high degree of in vivo cross-reactivity between A. vulgaris and M. chamomilla. Sensitization to A. vulgaris seems to be a primary risk factor for experiencing symptoms after the ingestion of chamomile infusions. Based on the results of bronchial provocation tests, M. chamomilla pollen could be a relevant inhalant allergen.

Topics: Administration, Oral; Adolescent; Adult; Allergens; Artemisia; Asthma; Bronchial Provocation Tests; Chamomile; Conjunctivitis, Allergic; Cross Reactions; Female; Humans; Male; Middle Aged; Rhinitis, Allergic, Perennial; Skin Tests

Topics: Asthma; Azulenes; Chamomile; Child; Dermatitis, Atopic; Eczema; Humans; Infant; Pharmaceutical Preparations

Topics: Asthma; Azulenes; Chamomile; Humans; Plant Extracts