aphidicolin and Hepatitis-C

aphidicolin has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for aphidicolin and Hepatitis-C

Article	Year
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8 A series of 2'-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2'-fluoro-2'-C-methyl adenosine C-nucleoside (15) was a potent and selective inhibitor of the NS5B polymerase and maintained activity against the S282T resistance mutant. A number of phosphoramidate prodrugs were then prepared and evaluated leading to the identification of the 1-aminocyclobutane-1-carboxylic acid isopropyl ester variant (53) with favorable pharmacokinetic properties including efficient liver delivery in animals. Topics: Amides; Animals; Antiviral Agents; Caco-2 Cells; Cell Line; Cricetinae; Drug Discovery; Drug Resistance, Viral; Halogenation; Hepacivirus; Hepatitis C; Humans; Methylation; Molecular Docking Simulation; Nucleosides; Phosphoric Acids; Point Mutation; Prodrugs; Viral Nonstructural Proteins; Virus Replication	2017

Article

Year

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8

A series of 2'-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2'-fluoro-2'-C-methyl adenosine C-nucleoside (15) was a potent and selective inhibitor of the NS5B polymerase and maintained activity against the S282T resistance mutant. A number of phosphoramidate prodrugs were then prepared and evaluated leading to the identification of the 1-aminocyclobutane-1-carboxylic acid isopropyl ester variant (53) with favorable pharmacokinetic properties including efficient liver delivery in animals.

Topics: Amides; Animals; Antiviral Agents; Caco-2 Cells; Cell Line; Cricetinae; Drug Discovery; Drug Resistance, Viral; Halogenation; Hepacivirus; Hepatitis C; Humans; Methylation; Molecular Docking Simulation; Nucleosides; Phosphoric Acids; Point Mutation; Prodrugs; Viral Nonstructural Proteins; Virus Replication

2017