apelin-13-peptide and Kidney-Failure--Chronic

Apelin is an adipokine secreted by the adipose tissue and by the endothelial cells in various parts of the body. Apelin is also expressed by the glomerular arteriolar rectus and glomerular capillary cells. We evaluated the relationship between the initial serum levels of apelin 13 with the trend of glomerular filtration rate (GFR) during a 1-year follow-up of patients with chronic kidney disease (CKD).. Ninety-nine patients with CKD in the predialysis stages were included and completed the study. The demographic data, medications, and comorbidities of the patients were recorded. The relationship between the baseline apelin 13 levels and the 1-year GFR loss was evaluated.   Results. The mean 1-year GFR loss 1.6 mL/min for those with CKD stage 3, 5.1 mL/min for those with CKD stage 4, and 2.6 mL/min for those with CKD stage 5. Fifty-eight patients (58.6%) had a GFR loss less than 5 mL/min and 41 (41.4%) had a GFR loss of 5 mL/min and greater, for whom the mean apelin 13 levels were 2169 ± 1807 mL/min and 2513 ± 1920 mL/min, respectively (P = .36).  There was no significant correlation between the apelin 13 levels and GFR loss (P = .35).. To our knowledge, this study was the first that clinically examined the relationship between apelin 13 and CKD progression. Apart from the diabetic nephropathy, several factors causing comorbidity and progression may have probably masked this potential relationship.

Topics: Adult; Aged; Disease Progression; Female; Glomerular Filtration Rate; Humans; Intercellular Signaling Peptides and Proteins; Kidney Failure, Chronic; Male; Middle Aged

Apelin and ADMA may have opposite impacts on the activity of NOS and production of NO. However, the circulating level and cardiovascular role of apelin are unclear in uremia patients with elevated ADMA. Our present study was to detect the serum level of apelin-13 and ADMA, and their correlations in maintenance hemodialysis (MHD) patients.. 159 MHD patients without heart failure (HF) and twenty healthy volunteers were enrolled. Pre- and post-dialysis concentrations of serum apelin-13 and ADMA in MHD patients and in controls were determined. Nitrite and nitrate (NOx) were measured at the same time. The levels of apelin-13, ADMA, and NOx in dialysate or ultrafiltrate were tested, and the total removal (TR) of them in 1 session were calculated. It was also analyzed for the correlations among apelin-13, ADMA, NOx, apelin/ADMA ratio and other clinical parameters, such as blood pressure, urea reduction rate (URR), and so on.. The serum levels of apelin-13 and ADMA in MHD patients were both higher than healthy controls (104.63 +/- 40.35 ng/ml versus 55.57 +/- 21.06 ng/ml, p = 0.016; 1.05 +/- 0.67microM vs. 0.35 +/- 0.06 microM, p = 0.002, respectively). There was no significant difference in serum NOx levels between MHD patients and healthy controls (58.30 +/- 40.09 microM vs. 68.11 +/- 13.63 microM, p = 0.596). Except for the significantly increased NOx (from 58.30 +/- 40.09 microM to 96.14 +/- 58.07 microM, p < 0.001), the serum levels of apelin-13 (from 104.63 +/- 40.35 ng/ml to 76.44 +/- 40.47 ng/ml, p = 0.012) and ADMA (from 1.05 +/- 0.67 microM to 0.83 +/- 0.53 microM, p < 0.001) decreased significantly after hemodialysis session. Apelin-13, ADMA, and NOx all can be removed by HD. The predialysis serum level of apelin-13 was positively correlated with the one of ADMA (r = 0.349, p = 0.001) and LDL (r = 0.204, p = 0.041), but ADMA was positively correlated with SCr (r = 0.277, p = 0.027). There were negative relationships between serum levels of ADMA and NOx for both pre- and post-dialysis (r = -0.344, p = 0.047, and r = -0.612, p = 0.001, respectively). The apelin/ADMA ratio had significantly negative correlations with systolic blood pressure (SBP) (for predialysis, r = -0.277, p = 0.037, for postdialysis r = -0.754, p = 0.019, respectively).. The serum concentrations of both ADMA and apelin-13 are increased in MHD patients without HF, and there were positive correlations between them predialysis. Both of them might affect patients blood pressure.

Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Female; Humans; Intercellular Signaling Peptides and Proteins; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitrites; Renal Dialysis; Time Factors