apelin-13-peptide and Dementia--Vascular

apelin-13-peptide has been researched along with Dementia--Vascular* in 1 studies

Other Studies

1 other study(ies) available for apelin-13-peptide and Dementia--Vascular

ArticleYear
Apelin receptor homodimer inhibits apoptosis in vascular dementia.
    Experimental cell research, 2021, 10-01, Volume: 407, Issue:1

    Apelin receptor (APJ), a member of family A of the G protein-coupled receptors (GPCRs), is a potential pharmaceutical target for diseases of the nervous system. Our previous work revealed that human APJ can form a homodimer that has different functional characteristics than the monomer. To investigate the effects of APJ homodimers on neuroprotection in vascular dementia (VD), we established VD model in rats and treated the animals by injecting apelin-13 into the lateral ventricle. In addition, we established an oxygen-glucose deprivation/reoxygenation (OGD/R) model in SH-SY5Y cells treated with apelin-13. After apelin-13 stimulation in the VD rat, the level of APJ and APJ homodimer were elevated. Furthermore, APJ homodimer decreased the level of cleaved caspase-3 and cleaved caspase-9 via the Gα

    Topics: Apelin Receptors; Apoptosis; Cell Death; Dementia, Vascular; Humans; Intercellular Signaling Peptides and Proteins; Neurons; Receptors, G-Protein-Coupled; Signal Transduction

2021