apatorsen and Neoplasms

apatorsen has been researched along with Neoplasms* in 1 studies

Reviews

1 review(s) available for apatorsen and Neoplasms

ArticleYear
Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors.
    International journal of molecular sciences, 2019, Oct-24, Volume: 20, Issue:21

    Most molecular chaperones belonging to heat shock protein (HSP) families are known to protect cancer cells from pathologic, environmental and pharmacological stress factors and thereby can hamper anti-cancer therapies. In this review, we present data on inhibitors of the heat shock response (particularly mediated by the chaperones HSP90, HSP70, and HSP27) either as a single treatment or in combination with currently available anti-cancer therapeutic approaches. An overview of the current literature reveals that the co-administration of chaperone inhibitors and targeting drugs results in proteotoxic stress and violates the tumor cell physiology. An optimal drug combination should simultaneously target cytoprotective mechanisms and trigger the imbalance of the tumor cell physiology.

    Topics: Antineoplastic Agents; Drug Therapy, Combination; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Molecular Chaperones; Neoplasms; Oligonucleotides; Resorcinols

2019