apatinib and Hypoxia
apatinib has been researched along with Hypoxia* in 1 studies
Other Studies
1 other study(ies) available for apatinib and Hypoxia
| Article | Year |
|---|---|
Low- dose Apatinib promotes vascular normalization and hypoxia reduction and sensitizes radiotherapy in lung cancer.
Abnormal vascular network of tumor can create a hypoxic microenvironment, and reduce radiotherapy sensitivity. Normalization of tumor vasculature can be a new therapeutic strategy for sensitizing radiotherapy. This study aimed to explore the effect of apatinib on vascular normalization, as well as the syngeneic effect with radiotherapy on lung cancer.. Lewis lung carcinoma (LLC) xenograft-bearing female C57BL/6 mice were treated with different doses of apatinib (30, 60, and 120 mg/kg per day) and/or radiation therapy (8 Gy/1F) and then sacrificed to harvest tumor tissue for immunohistochemical test. Further. Our data suggested that low- dose apatinib can successfully induce a vascular normalization window and function as a radio- sensitizer in the lung cancer xenografts model. Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Female; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Inbred C57BL; Radiation-Sensitizing Agents; Tumor Microenvironment | 2023 |