ap20187 and Neuralgia

ap20187 has been researched along with Neuralgia* in 2 studies

Other Studies

2 other study(ies) available for ap20187 and Neuralgia

ArticleYear
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain.
    Nature communications, 2020, 01-14, Volume: 11, Issue:1

    Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG). Here we demonstrate a critical contribution of DRG macrophages, but not those at the nerve injury site, to both the initiation and maintenance of the mechanical hypersensitivity that characterizes the neuropathic pain phenotype. In contrast to the reported sexual dimorphism in the microglial contribution to neuropathic pain, depletion of DRG macrophages reduces nerve injury-induced mechanical hypersensitivity and expansion of DRG macrophages in both male and female mice. However, fewer macrophages are induced in the female mice and deletion of colony-stimulating factor 1 from sensory neurons, which prevents nerve injury-induced microglial activation and proliferation, only reduces macrophage expansion in male mice. Finally, we demonstrate molecular cross-talk between axotomized sensory neurons and macrophages, revealing potential peripheral DRG targets for neuropathic pain management.

    Topics: Animals; Cell Communication; Cell Proliferation; Female; Ganglia, Spinal; Hyperalgesia; Immunosuppressive Agents; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microglia; Neuralgia; Peripheral Nerve Injuries; Pregnancy; Sensory Receptor Cells; Sex Factors; Tacrolimus

2020
Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-08, Volume: 38, Issue:32

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Communication; Cells, Cultured; Female; Ganglia, Spinal; Genes, Reporter; Humans; Hyperalgesia; Imidazoles; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neutrophil Activation; Oxidation-Reduction; Pyridines; Receptor, Angiotensin, Type 2; Sensory Receptor Cells; Skin; Tacrolimus; TRPA1 Cation Channel

2018