ap20187 and Encephalitis--Viral

ap20187 has been researched along with Encephalitis--Viral* in 1 studies

Other Studies

1 other study(ies) available for ap20187 and Encephalitis--Viral

ArticleYear
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.
    Journal of neuroimmunology, 2010, Sep-14, Volume: 226, Issue:1-2

    Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS.

    Topics: Animals; Apoptosis; Bone Density Conservation Agents; Central Nervous System; Clodronic Acid; Disease Models, Animal; Encephalitis, Viral; Flow Cytometry; Granulocytes; Green Fluorescent Proteins; Macrophages; Mice; Mice, Nude; Mice, Transgenic; Peritoneum; Tacrolimus; Vesiculovirus

2010