antofine has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for antofine and Breast-Neoplasms
Article | Year |
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[Preparation and anti-breast cancer activity of (-)-antofine carried with liposomes].
To prepare (-)-Antofine liposomes with high activity and good water-soluble and study its anti-breast cancer activity both in vitro and in vivo.. (-)-Antofine liposomes were prepared by film dispersion method, the encapsulation efficiency of (-)-Antofine liposomes were determined by UV spectrophotometer, the cytotoxic activity of (-)-Antofine liposomes on MCF-7 cell was measured by MTT assay, the antitumor activity and major organs indexes were evaluated by tumor-bearing nude mice experimental in vivo.. The average encapsulation efficiency of (-)-Antofine liposomes was (80.8 +/- 2.2)%, average drug loading was (26.7 +/- 1.4)%, it was relatively good water-soluble and had good anti-tumor activity in vitro and in vivo.. (-)-Antofine liposomes prepared by film dispersion method has high encapsulation efficiency, the water-soluble and the anti-tumor activity are improved compared with (-)-Antofine. Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Carriers; Drug Compounding; Drug Stability; Female; Humans; Indoles; Liposomes; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles; Particle Size; Phenanthrolines; Solubility; Xenograft Model Antitumor Assays | 2013 |