antofine and Adenocarcinoma

antofine has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for antofine and Adenocarcinoma

ArticleYear
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
    Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15

    Various E-ring hydroxylated antofine and cryptopleurine analogues were designed, synthesized, and tested against five human cancer cell lines. Interesting structure-activity relationship (SAR) correlations were found among these new compounds. The most potent compound 13b was further tested against a series of nonsmall cell lung cancer (NSCLC) cell lines in which it showed impressive antiproliferative activity. Mechanistic studies revealed that 13b is able to down-regulate HSP90 and β-catenin in A549 lung adenocarcinoma cells in a dose-dependent manner, suggesting a potential use for treating hedgehog pathway-driven tumorigenesis.

    Topics: Adenocarcinoma; Alkaloids; Antineoplastic Agents; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Design; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Indoles; Lung Neoplasms; Phenanthrolines; Quinolizidines; Stereoisomerism; Structure-Activity Relationship

2012