antipyrine has been researched along with Vasospasm, Intracranial in 4 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is induced by free radicals released from a subarachnoid clot." | 6.74 | Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. ( Asano, K; Munakata, A; Nakano, T; Naraoka, M; Ohkuma, H; Shimamura, N, 2009) |
| "The degree of cerebral vasospasm was evaluated by measuring the diameter of each basilar artery, and the expression of Rho-kinase in the vascular wall was examined by western blotting." | 5.37 | Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model. ( Munakata, A; Ohkuma, H; Shimamura, N, 2011) |
| "It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is induced by free radicals released from a subarachnoid clot." | 2.74 | Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. ( Asano, K; Munakata, A; Nakano, T; Naraoka, M; Ohkuma, H; Shimamura, N, 2009) |
| "Cerebral vasospasm is a major cause of cerebral ischemia and poor outcomes in the setting of aneurysmal subarachnoid hemorrhage (SAH)." | 2.44 | Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Lehmann, E; Sagher, O, 2008) |
| "The degree of cerebral vasospasm was evaluated by measuring the diameter of each basilar artery, and the expression of Rho-kinase in the vascular wall was examined by western blotting." | 1.37 | Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model. ( Munakata, A; Ohkuma, H; Shimamura, N, 2011) |
| "Cerebral vasospasm is one of the important pathological phenomena which influence morbidity and mortality following subarachnoid haemorrhage." | 1.31 | Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger. ( Hashiba, Y; Imai, H; Saito, N; Sasaki, T; Shimizu, T; Tosaka, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehmann, E | 1 |
| Sagher, O | 1 |
| Munakata, A | 2 |
| Ohkuma, H | 2 |
| Nakano, T | 1 |
| Shimamura, N | 2 |
| Asano, K | 1 |
| Naraoka, M | 1 |
| Tosaka, M | 1 |
| Hashiba, Y | 1 |
| Saito, N | 1 |
| Imai, H | 1 |
| Shimizu, T | 1 |
| Sasaki, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury[NCT03968042] | Phase 2 | 150 participants (Anticipated) | Interventional | 2019-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for antipyrine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Edaravone; Fibrinolytic Agents; Free Radical Scavenge | 2008 |
1 trial available for antipyrine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage.
Topics: Antipyrine; Cerebral Infarction; Comorbidity; Edaravone; Female; Free Radical Scavengers; Humans; Ja | 2009 |
2 other studies available for antipyrine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Effect of a free radical scavenger, edaravone, on free radical reactions: related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.
Topics: Animals; Antipyrine; Basilar Artery; Disease Models, Animal; Edaravone; Free Radical Scavengers; Gen | 2011 |
Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger.
Topics: Animals; Antipyrine; Basilar Artery; Disease Models, Animal; Dogs; Edaravone; Female; Free Radical S | 2002 |