antipyrine has been researched along with Uremia in 6 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urea pretreatment slows hexobarbital metabolsim and prolongs hexobarbital sleep times." | 1.26 | Effects of urea on hexobarbital and antipyrine disposition in rats. ( Bachmann, K; Valentovic, M, 1980) |
| "1." | 1.25 | The plasma half-life of antipyrine in chromic uraemic and normal subjects. ( Harber, MJ; Maddocks, JL; Wake, CJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Peer, AP | 1 |
| Belpaire, FM | 1 |
| Bogaert, MG | 1 |
| Valentovic, M | 1 |
| Bachmann, K | 1 |
| Bengtsson, U | 1 |
| Reidenberg, MM | 1 |
| Maddocks, JL | 1 |
| Wake, CJ | 1 |
| Harber, MJ | 1 |
| Grzegorzewska, A | 1 |
| Lowicki, Z | 1 |
| Chmara, E | 1 |
| Mrozikiewicz, A | 1 |
| Baczyk, K | 1 |
2 reviews available for antipyrine and Uremia
| Article | Year |
|---|---|
Prevention of renal disease.
Topics: Anti-Glomerular Basement Membrane Disease; Antipyrine; Caffeine; Chronic Disease; Female; Glomerulon | 1979 |
Drug metabolism in uremia.
Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidati | 1975 |
4 other studies available for antipyrine and Uremia
| Article | Year |
|---|---|
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in uraemic rabbits.
Topics: Animals; Antipyrine; Female; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Oxidation-Redu | 1980 |
Effects of urea on hexobarbital and antipyrine disposition in rats.
Topics: Animals; Antipyrine; Blood Urea Nitrogen; Cytochrome P-450 Enzyme System; Drug Interactions; Female; | 1980 |
The plasma half-life of antipyrine in chromic uraemic and normal subjects.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Enzyme Induction; Female; Half-Life; Humans; In | 1975 |
Assessment of liver ability to biotransformation of antipyrine in uraemic patients on regular peritoneal dialysis treatment.
Topics: Antipyrine; Biotransformation; Humans; Liver; Peritoneal Dialysis; Reference Values; Uremia | 1989 |