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antipyrine and Uremia

antipyrine has been researched along with Uremia in 6 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

ExcerptRelevanceReference
"Urea pretreatment slows hexobarbital metabolsim and prolongs hexobarbital sleep times."1.26Effects of urea on hexobarbital and antipyrine disposition in rats. ( Bachmann, K; Valentovic, M, 1980)
"1."1.25The plasma half-life of antipyrine in chromic uraemic and normal subjects. ( Harber, MJ; Maddocks, JL; Wake, CJ, 1975)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Van Peer, AP1
Belpaire, FM1
Bogaert, MG1
Valentovic, M1
Bachmann, K1
Bengtsson, U1
Reidenberg, MM1
Maddocks, JL1
Wake, CJ1
Harber, MJ1
Grzegorzewska, A1
Lowicki, Z1
Chmara, E1
Mrozikiewicz, A1
Baczyk, K1

Reviews

2 reviews available for antipyrine and Uremia

ArticleYear
Prevention of renal disease.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1979, Volume: 16

    Topics: Anti-Glomerular Basement Membrane Disease; Antipyrine; Caffeine; Chronic Disease; Female; Glomerulon

1979
Drug metabolism in uremia.
    Clinical nephrology, 1975, Volume: 4, Issue:3

    Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidati

1975

Other Studies

4 other studies available for antipyrine and Uremia

ArticleYear
In vitro hepatic oxidative metabolism of antipyrine, phenytoin and phenylbutazone in uraemic rabbits.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:2

    Topics: Animals; Antipyrine; Female; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Oxidation-Redu

1980
Effects of urea on hexobarbital and antipyrine disposition in rats.
    Pharmacology, 1980, Volume: 21, Issue:3

    Topics: Animals; Antipyrine; Blood Urea Nitrogen; Cytochrome P-450 Enzyme System; Drug Interactions; Female;

1980
The plasma half-life of antipyrine in chromic uraemic and normal subjects.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Enzyme Induction; Female; Half-Life; Humans; In

1975
Assessment of liver ability to biotransformation of antipyrine in uraemic patients on regular peritoneal dialysis treatment.
    International urology and nephrology, 1989, Volume: 21, Issue:5

    Topics: Antipyrine; Biotransformation; Humans; Liver; Peritoneal Dialysis; Reference Values; Uremia

1989