antipyrine has been researched along with Spinal Cord Injuries in 13 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edaravone is a scavenger of hydroxyl radicals." | 1.37 | Protective effects of edaravone on experimental spinal cord injury in rats. ( Altaş, M; Aras, M; Oran, I; Ozgiray, E; Oztürk, OH; Serarslan, Y; Söğüt, S; Yurtseven, T; Zileli, M, 2011) |
| "Pretreatment with edaravone significantly improved motor dysfunction and reduced the lesion volume to about 63% of the control (p < 0." | 1.35 | Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model. ( Aoyama, T; Hida, K; Iwasaki, Y; Kuroda, S; Seki, T; Shichinohe, H; Yano, S, 2008) |
| "Edaravone was administered intravenously as a bolus dose of 5 mg/kg at 5 minutes, 24 hours, and 48 hours after injury (edaravone-treated rats)." | 1.33 | Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats. ( Iwashita, Y; Kuno, S; Nakamura, T; Ohta, S; Takada, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishii, H | 1 |
| Petrenko, AB | 1 |
| Sasaki, M | 1 |
| Satoh, Y | 1 |
| Kamiya, Y | 1 |
| Tobita, T | 1 |
| Furutani, K | 1 |
| Matsuhashi, M | 1 |
| Kohno, T | 1 |
| Baba, H | 1 |
| Wang, J | 1 |
| Guo, G | 1 |
| Wang, W | 1 |
| Tang, Y | 1 |
| Shun, J | 1 |
| Zhou, X | 1 |
| Zhang, P | 1 |
| Song, YY | 1 |
| Peng, CG | 1 |
| Ye, XB | 1 |
| Aoyama, T | 1 |
| Hida, K | 1 |
| Kuroda, S | 1 |
| Seki, T | 1 |
| Yano, S | 1 |
| Shichinohe, H | 1 |
| Iwasaki, Y | 1 |
| Ohta, S | 2 |
| Iwashita, Y | 2 |
| Kakinoki, R | 1 |
| Noguchi, T | 1 |
| Nakamura, T | 2 |
| Ozgiray, E | 1 |
| Serarslan, Y | 1 |
| Oztürk, OH | 1 |
| Altaş, M | 1 |
| Aras, M | 1 |
| Söğüt, S | 1 |
| Yurtseven, T | 1 |
| Oran, I | 1 |
| Zileli, M | 1 |
| Takahashi, G | 1 |
| Sakurai, M | 1 |
| Abe, K | 1 |
| Itoyama, Y | 1 |
| Tabayashi, K | 1 |
| Takada, H | 1 |
| Kuno, S | 1 |
| Cawthon, DF | 1 |
| Senter, HJ | 1 |
| Stewart, WB | 1 |
| Dolan, EJ | 1 |
| Transfeldt, EE | 1 |
| Tator, CH | 1 |
| Simmons, EH | 1 |
| Hughes, KF | 1 |
| Imamura, H | 1 |
| Bingham, WG | 1 |
| Goldman, H | 1 |
| Friedman, SJ | 1 |
| Murphy, S | 1 |
| Yashon, D | 1 |
| Hunt, WE | 1 |
| Wineinger, MA | 1 |
| Basford, JR | 1 |
13 other studies available for antipyrine and Spinal Cord Injuries
| Article | Year |
|---|---|
Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Antipyrine; Cytokines; Disease Models, | 2018 |
Effect of methylprednisolone and edaravone administration on spinal cord injury.
Topics: Animals; Antipyrine; bcl-X Protein; Caspase 3; Edaravone; Methylprednisolone; Rats; Rats, Sprague-Da | 2013 |
Combination of edaravone and neural stem cell transplantation repairs injured spinal cord in rats.
Topics: Animals; Antipyrine; Cell Differentiation; Cell Movement; Cell Survival; Edaravone; Female; Fluoresc | 2015 |
Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model.
Topics: Animals; Antipyrine; Drug Evaluation, Preclinical; Edaravone; Female; Free Radical Scavengers; Hindl | 2008 |
Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.
Topics: Animals; Antipyrine; Disease Models, Animal; Drug Administration Schedule; Edaravone; Free Radical S | 2011 |
Protective effects of edaravone on experimental spinal cord injury in rats.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Methylprednis | 2011 |
MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.
Topics: Animals; Antipyrine; Biopsy, Needle; Disease Models, Animal; Edaravone; Immunohistochemistry; Inject | 2003 |
Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hindlimb; Injections, Intrav | 2005 |
Comparison of hydrogen clearance and 14C-antipyrine autoradiography in the measurement of spinal cord blood flow after severe impact injury.
Topics: Animals; Antipyrine; Autoradiography; Blood Flow Velocity; Carbon Radioisotopes; Cats; Hydrogen; Met | 1980 |
The effect of spinal distraction on regional spinal cord blood flow in cats.
Topics: Animals; Antipyrine; Autoradiography; Cats; Electrophysiology; Evoked Potentials; Female; Ischemia; | 1980 |
[Effects of megadose methylprednisolone therapy on acute spinal cord injury in rats].
Topics: Acute Disease; Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Methylprednisolone; Rats; | 1994 |
Blood flow in normal and injured monkey spinal cord.
Topics: Animals; Antipyrine; Autoradiography; Carbon Dioxide; Carbon Radioisotopes; Cardiac Output; Cats; Ch | 1975 |
Autonomic dysreflexia due to medication: misadventure in the use of an isometheptene combination to treat migraine.
Topics: Acetaminophen; Adult; Antipyrine; Autonomic Nervous System; Blood Pressure; Chloral Hydrate; Drug Co | 1985 |